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Protein

Choline/ethanolaminephosphotransferase 1

Gene

cept1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface (By similarity).By similarity

Catalytic activityi

CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.

Cofactori

Mg2+By similarity, Mn2+By similarity

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Choline/ethanolaminephosphotransferase 1 (cept1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Choline/ethanolaminephosphotransferase 1 (cept1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-XTR-1483191. Synthesis of PC.
R-XTR-1483213. Synthesis of PE.
UniPathwayiUPA00558; UER00743.
UPA00753; UER00740.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline/ethanolaminephosphotransferase 1 (EC:2.7.8.1, EC:2.7.8.2)
Gene namesi
Name:cept1
ORF Names:TEgg057p14.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1003923. cept1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei249 – 271HelicalSequence analysisAdd BLAST23
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892501 – 416Choline/ethanolaminephosphotransferase 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ28H54.

Expressioni

Gene expression databases

BgeeiENSXETG00000004387.
ExpressionAtlasiQ28H54. differential.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000009560.

Structurei

3D structure databases

ProteinModelPortaliQ28H54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000230699.
HOVERGENiHBG107647.
InParanoidiQ28H54.
KOiK13644.
OMAiRTIDHYL.
OrthoDBiEOG091G07XY.
TreeFamiTF313270.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28H54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQRAAKRR TGDLHTEFPT SCGNPYQTAC LLSKFIELPT PPLTRHQLKR
60 70 80 90 100
LEEHRYQSCG KSLLEPIMQG FWEWLVEQVP QWIAPNLITI IGLLINIITT
110 120 130 140 150
VVLVYYCPTA TEKAPTWTYL SCAIGLFIYQ SLDAIDGKQA RRTNSSTPLG
160 170 180 190 200
ELFDHGCDSL STVFVVLGTC IAVQLGTNPD WMFFCCFAGM FMFYCAHWQT
210 220 230 240 250
YVSGTLRFGI IDVTEVQIFI IIMHLLAAIG GPTLWLSMIP VLNVPMKLFP
260 270 280 290 300
ALCTVAGTVF SCTNYFRVIF TGGVGKNGST IAGTSVLSPM LHIGSVIVLA
310 320 330 340 350
TMIYKKSSVQ LFEKHPCLYI LTFGFVSAKV TNKLVVAHMT KSEMHLHDSA
360 370 380 390 400
FIGPALLFLN QYFNSFIDEH LVLWIALVLS FIDLIRYSVS ICNQIASHLH
410
IEVFRIKTKV ARFNHH
Length:416
Mass (Da):46,606
Last modified:April 4, 2006 - v1
Checksum:i055DEDEC22EE6335
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761040 mRNA. Translation: CAJ81969.1.
RefSeqiNP_001016434.1. NM_001016434.3.
XP_012817768.1. XM_012962314.2.
XP_012817772.1. XM_012962318.2.
UniGeneiStr.65331.

Genome annotation databases

EnsembliENSXETT00000009560; ENSXETP00000009560; ENSXETG00000004387.
GeneIDi549188.
KEGGixtr:549188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761040 mRNA. Translation: CAJ81969.1.
RefSeqiNP_001016434.1. NM_001016434.3.
XP_012817768.1. XM_012962314.2.
XP_012817772.1. XM_012962318.2.
UniGeneiStr.65331.

3D structure databases

ProteinModelPortaliQ28H54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000009560.

Proteomic databases

PaxDbiQ28H54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000009560; ENSXETP00000009560; ENSXETG00000004387.
GeneIDi549188.
KEGGixtr:549188.

Organism-specific databases

CTDi10390.
XenbaseiXB-GENE-1003923. cept1.

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000230699.
HOVERGENiHBG107647.
InParanoidiQ28H54.
KOiK13644.
OMAiRTIDHYL.
OrthoDBiEOG091G07XY.
TreeFamiTF313270.

Enzyme and pathway databases

UniPathwayiUPA00558; UER00743.
UPA00753; UER00740.
ReactomeiR-XTR-1483191. Synthesis of PC.
R-XTR-1483213. Synthesis of PE.

Gene expression databases

BgeeiENSXETG00000004387.
ExpressionAtlasiQ28H54. differential.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEPT1_XENTR
AccessioniPrimary (citable) accession number: Q28H54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.