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Q28GQ2 (MECR_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:mecr
ORF Names:TEgg103l11.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity. Functions in pronephros development, regulating late differentiation of all pronephric tubule segments. Ref.2

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH. UniProtKB O43715

Subunit structure

Homodimer By similarity. UniProtKB O43715

Subcellular location

Mitochondrion By similarity UniProtKB O43715.

Tissue specificity

Expressed in the developing pronephros. Ref.2

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1212Mitochondrion Potential
Chain13 – 350338Trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000391692

Regions

Nucleotide binding167 – 1704NADP By similarity
Nucleotide binding190 – 1923NADP By similarity
Nucleotide binding259 – 2624NADP By similarity
Nucleotide binding284 – 2863NADP By similarity

Sites

Binding site1411NADP By similarity
Binding site3451NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28GQ2 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 48814881CBDED83B

FASTA35038,669
        10         20         30         40         50         60 
MWLGLRLFHR PFSSLAARGL VYEKHGEPLQ VLRLKNVNIT HPADNEVRVK MLAAPINPSD 

        70         80         90        100        110        120 
INMVQGTYAL LPQLPAVGGN EGVGVVVEIG RHVSSMRPGD WVVPVDAGLG TWCTEAVFSE 

       130        140        150        160        170        180 
DSLVRVPSDI PVAGAATVSV NPCTAYRLLS DFETLRPGDT IIQNASNSGV GQAVIQIATS 

       190        200        210        220        230        240 
LGITTINVVR DREDLSSLIQ RLRDLGADHV ITEEQLRKPE MKDLFKNCPR PRLALNCVGG 

       250        260        270        280        290        300 
KSTTEMLRHL DYGGTMVTYG GMSKQPVTVP VSALIFKNVK LCGFWVTQWK KERAQTDREE 

       310        320        330        340        350 
IVKMIRDLCD LIRRGKLVPP PSTQRPLEDF SRALQDSQTP FLSRKQILIM 

« Hide

References

« Hide 'large scale' references
[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]"A functional screen for genes involved in Xenopus pronephros development."
Kyuno J., Masse K., Jones E.A.
Mech. Dev. 125:571-586(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR761275 mRNA. Translation: CAJ83709.1.
RefSeqNP_001016371.1. NM_001016371.2.
UniGeneStr.26937.

3D structure databases

ProteinModelPortalQ28GQ2.
SMRQ28GQ2. Positions 12-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000031439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000031439; ENSXETP00000031439; ENSXETG00000014371.
GeneID549125.
KEGGxtr:549125.

Organism-specific databases

CTD51102.
XenbaseXB-GENE-1007523. mecr.

Phylogenomic databases

eggNOGCOG0604.
GeneTreeENSGT00740000115589.
HOGENOMHOG000294683.
HOVERGENHBG052446.
KOK07512.
OMAGSGQWFI.
OrthoDBEOG78M024.
TreeFamTF312886.

Gene expression databases

BgeeQ28GQ2.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMECR_XENTR
AccessionPrimary (citable) accession number: Q28GQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: April 4, 2006
Last modified: March 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families