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Q28GQ2

- MECR_XENTR

UniProt

Q28GQ2 - MECR_XENTR

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Protein
Trans-2-enoyl-CoA reductase, mitochondrial
Gene
mecr, TEgg103l11.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity. Functions in pronephros development, regulating late differentiation of all pronephric tubule segments.1 Publication

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411NADP By similarity
Binding sitei345 – 3451NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi167 – 1704NADP By similarity
Nucleotide bindingi190 – 1923NADP By similarity
Nucleotide bindingi259 – 2624NADP By similarity
Nucleotide bindingi284 – 2863NADP By similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. pronephric nephron tubule development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:mecr
ORF Names:TEgg103l11.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1007523. mecr.

Subcellular locationi

Mitochondrion By similarity By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212Mitochondrion Reviewed prediction
Add
BLAST
Chaini13 – 350338Trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000391692Add
BLAST

Expressioni

Tissue specificityi

Expressed in the developing pronephros.1 Publication

Gene expression databases

BgeeiQ28GQ2.

Interactioni

Subunit structurei

Homodimer By similarity.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000031439.

Structurei

3D structure databases

ProteinModelPortaliQ28GQ2.
SMRiQ28GQ2. Positions 12-350.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
KOiK07512.
OMAiGSGQWFI.
OrthoDBiEOG78M024.
TreeFamiTF312886.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28GQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MWLGLRLFHR PFSSLAARGL VYEKHGEPLQ VLRLKNVNIT HPADNEVRVK    50
MLAAPINPSD INMVQGTYAL LPQLPAVGGN EGVGVVVEIG RHVSSMRPGD 100
WVVPVDAGLG TWCTEAVFSE DSLVRVPSDI PVAGAATVSV NPCTAYRLLS 150
DFETLRPGDT IIQNASNSGV GQAVIQIATS LGITTINVVR DREDLSSLIQ 200
RLRDLGADHV ITEEQLRKPE MKDLFKNCPR PRLALNCVGG KSTTEMLRHL 250
DYGGTMVTYG GMSKQPVTVP VSALIFKNVK LCGFWVTQWK KERAQTDREE 300
IVKMIRDLCD LIRRGKLVPP PSTQRPLEDF SRALQDSQTP FLSRKQILIM 350
Length:350
Mass (Da):38,669
Last modified:April 4, 2006 - v1
Checksum:i48814881CBDED83B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761275 mRNA. Translation: CAJ83709.1.
RefSeqiNP_001016371.1. NM_001016371.2.
UniGeneiStr.26937.

Genome annotation databases

EnsembliENSXETT00000031439; ENSXETP00000031439; ENSXETG00000014371.
GeneIDi549125.
KEGGixtr:549125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761275 mRNA. Translation: CAJ83709.1 .
RefSeqi NP_001016371.1. NM_001016371.2.
UniGenei Str.26937.

3D structure databases

ProteinModelPortali Q28GQ2.
SMRi Q28GQ2. Positions 12-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000031439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000031439 ; ENSXETP00000031439 ; ENSXETG00000014371 .
GeneIDi 549125.
KEGGi xtr:549125.

Organism-specific databases

CTDi 51102.
Xenbasei XB-GENE-1007523. mecr.

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00740000115589.
HOGENOMi HOG000294683.
HOVERGENi HBG052446.
KOi K07512.
OMAi GSGQWFI.
OrthoDBi EOG78M024.
TreeFami TF312886.

Gene expression databases

Bgeei Q28GQ2.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. "A functional screen for genes involved in Xenopus pronephros development."
    Kyuno J., Masse K., Jones E.A.
    Mech. Dev. 125:571-586(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiMECR_XENTR
AccessioniPrimary (citable) accession number: Q28GQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: April 4, 2006
Last modified: March 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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