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Q28GQ2

- MECR_XENTR

UniProt

Q28GQ2 - MECR_XENTR

Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

mecr

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity. Functions in pronephros development, regulating late differentiation of all pronephric tubule segments.By similarity1 Publication

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411NADPBy similarity
    Binding sitei345 – 3451NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi167 – 1704NADPBy similarity
    Nucleotide bindingi190 – 1923NADPBy similarity
    Nucleotide bindingi259 – 2624NADPBy similarity
    Nucleotide bindingi284 – 2863NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW
    2. pronephric nephron tubule development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrialBy similarity (EC:1.3.1.38)
    Gene namesi
    Name:mecrImported
    ORF Names:TEgg103l11.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1007523. mecr.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1212MitochondrionSequence AnalysisAdd
    BLAST
    Chaini13 – 350338Trans-2-enoyl-CoA reductase, mitochondrialSequence AnalysisPRO_0000391692Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the developing pronephros.1 Publication

    Gene expression databases

    BgeeiQ28GQ2.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000031439.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28GQ2.
    SMRiQ28GQ2. Positions 12-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    GeneTreeiENSGT00740000115589.
    HOGENOMiHOG000294683.
    HOVERGENiHBG052446.
    KOiK07512.
    OMAiGSGQWFI.
    OrthoDBiEOG78M024.
    TreeFamiTF312886.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28GQ2-1 [UniParc]FASTAAdd to Basket

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    MWLGLRLFHR PFSSLAARGL VYEKHGEPLQ VLRLKNVNIT HPADNEVRVK    50
    MLAAPINPSD INMVQGTYAL LPQLPAVGGN EGVGVVVEIG RHVSSMRPGD 100
    WVVPVDAGLG TWCTEAVFSE DSLVRVPSDI PVAGAATVSV NPCTAYRLLS 150
    DFETLRPGDT IIQNASNSGV GQAVIQIATS LGITTINVVR DREDLSSLIQ 200
    RLRDLGADHV ITEEQLRKPE MKDLFKNCPR PRLALNCVGG KSTTEMLRHL 250
    DYGGTMVTYG GMSKQPVTVP VSALIFKNVK LCGFWVTQWK KERAQTDREE 300
    IVKMIRDLCD LIRRGKLVPP PSTQRPLEDF SRALQDSQTP FLSRKQILIM 350
    Length:350
    Mass (Da):38,669
    Last modified:April 4, 2006 - v1
    Checksum:i48814881CBDED83B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761275 mRNA. Translation: CAJ83709.1.
    RefSeqiNP_001016371.1. NM_001016371.2.
    UniGeneiStr.26937.

    Genome annotation databases

    EnsembliENSXETT00000031439; ENSXETP00000031439; ENSXETG00000014371.
    GeneIDi549125.
    KEGGixtr:549125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761275 mRNA. Translation: CAJ83709.1 .
    RefSeqi NP_001016371.1. NM_001016371.2.
    UniGenei Str.26937.

    3D structure databases

    ProteinModelPortali Q28GQ2.
    SMRi Q28GQ2. Positions 12-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000031439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000031439 ; ENSXETP00000031439 ; ENSXETG00000014371 .
    GeneIDi 549125.
    KEGGi xtr:549125.

    Organism-specific databases

    CTDi 51102.
    Xenbasei XB-GENE-1007523. mecr.

    Phylogenomic databases

    eggNOGi COG0604.
    GeneTreei ENSGT00740000115589.
    HOGENOMi HOG000294683.
    HOVERGENi HBG052446.
    KOi K07512.
    OMAi GSGQWFI.
    OrthoDBi EOG78M024.
    TreeFami TF312886.

    Gene expression databases

    Bgeei Q28GQ2.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EggImported.
    2. "A functional screen for genes involved in Xenopus pronephros development."
      Kyuno J., Masse K., Jones E.A.
      Mech. Dev. 125:571-586(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMECR_XENTR
    AccessioniPrimary (citable) accession number: Q28GQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3