Q28GQ2 (MECR_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial
EC=1.3.1.38

Gene names

Name:	mecr
ORF Names:	TEgg103l11.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity. Functions in pronephros development, regulating late differentiation of all pronephric tubule segments. Ref.2 UniProtKB O43715
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH. UniProtKB O43715
Subunit structure	Homodimer By similarity. UniProtKB O43715
Subcellular location	Mitochondrion By similarity UniProtKB O43715.
Tissue specificity	Expressed in the developing pronephros. Ref.2
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Developmental protein Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW pronephric nephron tubule development Inferred from mutant phenotype Ref.2. Source: UniProtKB
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 12	12	Mitochondrion Potential
	Chain	13 – 350	338	Trans-2-enoyl-CoA reductase, mitochondrial		PRO_0000391692

Sequences

	Sequence		Length	Mass (Da)
	Q28GQ2 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 48814881CBDED83B	FASTA	350	38,669
	10 20 30 40 50 60 MWLGLRLFHR PFSSLAARGL VYEKHGEPLQ VLRLKNVNIT HPADNEVRVK MLAAPINPSD 70 80 90 100 110 120 INMVQGTYAL LPQLPAVGGN EGVGVVVEIG RHVSSMRPGD WVVPVDAGLG TWCTEAVFSE 130 140 150 160 170 180 DSLVRVPSDI PVAGAATVSV NPCTAYRLLS DFETLRPGDT IIQNASNSGV GQAVIQIATS 190 200 210 220 230 240 LGITTINVVR DREDLSSLIQ RLRDLGADHV ITEEQLRKPE MKDLFKNCPR PRLALNCVGG 250 260 270 280 290 300 KSTTEMLRHL DYGGTMVTYG GMSKQPVTVP VSALIFKNVK LCGFWVTQWK KERAQTDREE 310 320 330 340 350 IVKMIRDLCD LIRRGKLVPP PSTQRPLEDF SRALQDSQTP FLSRKQILIM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg.
[2]	"A functional screen for genes involved in Xenopus pronephros development." Kyuno J., Masse K., Jones E.A. Mech. Dev. 125:571-586(2008) [PubMed: 18472403] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR761275 mRNA. Translation: CAJ83709.1.
RefSeq	NP_001016371.1. NM_001016371.2.
UniGene	Str.26937.
3D structure databases
ProteinModelPortal	Q28GQ2.
SMR	Q28GQ2. Positions 12-350.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28GQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000031439; ENSXETP00000031439; ENSXETG00000014371.
GeneID	549125.
KEGG	xtr:549125.
Organism-specific databases
CTD	51102.
Xenbase	XB-GENE-1007523. mecr.
Phylogenomic databases
eggNOG	veNOG06583.
GeneTree	ENSGT00550000074938.
HOVERGEN	HBG052446.
OMA	RGFWMTR.
OrthoDB	EOG43N7DB.
Gene expression databases
Bgee	Q28GQ2.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K07512.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MECR_XENTR

Accession

Primary (citable) accession number: Q28GQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 2, 2010
Last sequence update:	April 4, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program