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Protein

TATA-box-binding protein

Gene

tbp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis (By similarity). Binds to the promoters of select genes.By similarity1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. DNA-templated transcription, initiation Source: InterPro
  2. embryo development Source: UniProtKB
  3. gastrulation Source: Ensembl
  4. mRNA catabolic process Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_272955. RNA Polymerase II Pre-transcription Events.
REACT_280747. RNA Polymerase I Transcription Termination.
REACT_286567. SIRT1 negatively regulates rRNA Expression.
REACT_290816. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_290995. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_298365. RNA Polymerase II Transcription Initiation.
REACT_301279. RNA Polymerase I Transcription Initiation.
REACT_315090. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_319111. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_332879. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_336102. RNA Polymerase III Abortive And Retractive Initiation.
REACT_352141. RNA Polymerase II Promoter Escape.
REACT_352996. RNA Polymerase I Promoter Escape.
REACT_354425. RNA Polymerase I Chain Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding proteinBy similarity
Alternative name(s):
TATA sequence-binding proteinBy similarity
TATA-binding factorBy similarity
TATA-box factorBy similarity
Transcription initiation factor TFIID TBP subunitBy similarity
Gene namesi
Name:tbpImported
Synonyms:tfiidBy similarity
ORF Names:TEgg042d23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-488470. tbp.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297TATA-box-binding proteinPRO_0000348609Add
BLAST

Post-translational modificationi

The N-terminal domain is extensively phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiQ28GG8.
ExpressionAtlasiQ28GG8. baseline.

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ28GG8.
SMRiQ28GG8. Positions 117-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati123 – 199771Sequence AnalysisAdd
BLAST
Repeati213 – 290782Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 8330Gln-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TBP family.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2101.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiQ28GG8.
KOiK03120.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28GG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNNSIPPF QGLASPQGSL TPGINIFSPL MPYGTGLTPQ PVQTTNSLSI
60 70 80 90 100
LEEQQRQQQQ AQQSTSQQGN QGSGQTPQLF HPQTLTTAPL PGNTPLYPSP
110 120 130 140 150
MTPMTPITPA TPASESSGIV PQLQNIVSTV NLGCKLDLKT IALRARNAEY
160 170 180 190 200
NPKRFAAVIM RIREPRTTAL IFSSGKMVCT GAKSEEQSRL AARKYARVVQ
210 220 230 240 250
KLGFPAKFLD FKIQNMVGSC DVKFPIRLEG LVLTHQQFSS YEPELFPGLI
260 270 280 290
YRMIKPRIVL LIFVSGKVVL TGAKVRAEIY EAFENIYPIL KGFRKTT
Length:297
Mass (Da):32,693
Last modified:April 3, 2006 - v1
Checksum:i0CBF63B82EEA1A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761393 mRNA. Translation: CAJ83650.1.
BC160510 mRNA. Translation: AAI60510.1.
RefSeqiNP_001016339.1. NM_001016339.3.
UniGeneiStr.6374.

Genome annotation databases

GeneIDi549093.
KEGGixtr:549093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761393 mRNA. Translation: CAJ83650.1.
BC160510 mRNA. Translation: AAI60510.1.
RefSeqiNP_001016339.1. NM_001016339.3.
UniGeneiStr.6374.

3D structure databases

ProteinModelPortaliQ28GG8.
SMRiQ28GG8. Positions 117-296.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi549093.
KEGGixtr:549093.

Organism-specific databases

CTDi6908.
XenbaseiXB-GENE-488470. tbp.

Phylogenomic databases

eggNOGiCOG2101.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiQ28GG8.
KOiK03120.

Enzyme and pathway databases

ReactomeiREACT_272955. RNA Polymerase II Pre-transcription Events.
REACT_280747. RNA Polymerase I Transcription Termination.
REACT_286567. SIRT1 negatively regulates rRNA Expression.
REACT_290816. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_290995. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_298365. RNA Polymerase II Transcription Initiation.
REACT_301279. RNA Polymerase I Transcription Initiation.
REACT_315090. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_319111. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_332879. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_336102. RNA Polymerase III Abortive And Retractive Initiation.
REACT_352141. RNA Polymerase II Promoter Escape.
REACT_352996. RNA Polymerase I Promoter Escape.
REACT_354425. RNA Polymerase I Chain Elongation.

Gene expression databases

BgeeiQ28GG8.
ExpressionAtlasiQ28GG8. baseline.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EggImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  3. "TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation."
    Jacobi U.G., Akkers R.C., Pierson E.S., Weeks D.L., Dagle J.M., Veenstra G.J.C.
    EMBO J. 26:3900-3909(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTBP_XENTR
AccessioniPrimary (citable) accession number: Q28GG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2008
Last sequence update: April 3, 2006
Last modified: March 31, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.