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Q28GG8

- TBP_XENTR

UniProt

Q28GG8 - TBP_XENTR

Protein

TATA-box-binding protein

Gene

tbp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis By similarity. Binds to the promoters of select genes.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. embryo development Source: UniProtKB
    3. gastrulation Source: Ensembl
    4. mRNA catabolic process Source: Ensembl
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_221853. SIRT1 negatively regulates rRNA Expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA-box-binding proteinBy similarity
    Alternative name(s):
    TATA sequence-binding proteinBy similarity
    TATA-binding factorBy similarity
    TATA-box factorBy similarity
    Transcription initiation factor TFIID TBP subunitBy similarity
    Gene namesi
    Name:tbpImported
    Synonyms:tfiidBy similarity
    ORF Names:TEgg042d23.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-488470. tbp.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297TATA-box-binding proteinPRO_0000348609Add
    BLAST

    Post-translational modificationi

    The N-terminal domain is extensively phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    BgeeiQ28GG8.

    Interactioni

    Subunit structurei

    Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ28GG8.
    SMRiQ28GG8. Positions 117-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati123 – 199771Sequence AnalysisAdd
    BLAST
    Repeati213 – 290782Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 8330Gln-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TBP family.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2101.
    HOGENOMiHOG000105164.
    HOVERGENiHBG044997.
    KOiK03120.

    Family and domain databases

    Gene3Di3.30.310.10. 2 hits.
    HAMAPiMF_00408. TATA_bind_prot_arch.
    InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view]
    PANTHERiPTHR10126. PTHR10126. 1 hit.
    PfamiPF00352. TBP. 2 hits.
    [Graphical view]
    PRINTSiPR00686. TIFACTORIID.
    PROSITEiPS00351. TFIID. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28GG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQNNSIPPF QGLASPQGSL TPGINIFSPL MPYGTGLTPQ PVQTTNSLSI    50
    LEEQQRQQQQ AQQSTSQQGN QGSGQTPQLF HPQTLTTAPL PGNTPLYPSP 100
    MTPMTPITPA TPASESSGIV PQLQNIVSTV NLGCKLDLKT IALRARNAEY 150
    NPKRFAAVIM RIREPRTTAL IFSSGKMVCT GAKSEEQSRL AARKYARVVQ 200
    KLGFPAKFLD FKIQNMVGSC DVKFPIRLEG LVLTHQQFSS YEPELFPGLI 250
    YRMIKPRIVL LIFVSGKVVL TGAKVRAEIY EAFENIYPIL KGFRKTT 297
    Length:297
    Mass (Da):32,693
    Last modified:April 4, 2006 - v1
    Checksum:i0CBF63B82EEA1A9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761393 mRNA. Translation: CAJ83650.1.
    BC160510 mRNA. Translation: AAI60510.1.
    RefSeqiNP_001016339.1. NM_001016339.3.
    UniGeneiStr.6374.

    Genome annotation databases

    GeneIDi549093.
    KEGGixtr:549093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761393 mRNA. Translation: CAJ83650.1 .
    BC160510 mRNA. Translation: AAI60510.1 .
    RefSeqi NP_001016339.1. NM_001016339.3.
    UniGenei Str.6374.

    3D structure databases

    ProteinModelPortali Q28GG8.
    SMRi Q28GG8. Positions 117-296.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 549093.
    KEGGi xtr:549093.

    Organism-specific databases

    CTDi 6908.
    Xenbasei XB-GENE-488470. tbp.

    Phylogenomic databases

    eggNOGi COG2101.
    HOGENOMi HOG000105164.
    HOVERGENi HBG044997.
    KOi K03120.

    Enzyme and pathway databases

    Reactomei REACT_221853. SIRT1 negatively regulates rRNA Expression.

    Gene expression databases

    Bgeei Q28GG8.

    Family and domain databases

    Gene3Di 3.30.310.10. 2 hits.
    HAMAPi MF_00408. TATA_bind_prot_arch.
    InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view ]
    PANTHERi PTHR10126. PTHR10126. 1 hit.
    Pfami PF00352. TBP. 2 hits.
    [Graphical view ]
    PRINTSi PR00686. TIFACTORIID.
    PROSITEi PS00351. TFIID. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EggImported.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EmbryoImported.
    3. "TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation."
      Jacobi U.G., Akkers R.C., Pierson E.S., Weeks D.L., Dagle J.M., Veenstra G.J.C.
      EMBO J. 26:3900-3909(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTBP_XENTR
    AccessioniPrimary (citable) accession number: Q28GG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3