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Protein

TATA-box-binding protein

Gene

tbp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis (By similarity). Binds to the promoters of select genes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding proteinBy similarity
Alternative name(s):
TATA sequence-binding proteinBy similarity
TATA-binding factorBy similarity
TATA-box factorBy similarity
Transcription initiation factor TFIID TBP subunitBy similarity
Gene namesi
Name:tbpImported
Synonyms:tfiidBy similarity
ORF Names:TEgg042d23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-488470. tbp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003486091 – 297TATA-box-binding proteinAdd BLAST297

Post-translational modificationi

The N-terminal domain is extensively phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ28GG8.

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000018725.

Structurei

3D structure databases

ProteinModelPortaliQ28GG8.
SMRiQ28GG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati123 – 1991Sequence analysisAdd BLAST77
Repeati213 – 2902Sequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 83Gln-richSequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the TBP family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiQ28GG8.
KOiK03120.
OrthoDBiEOG091G0ENY.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiView protein in InterPro
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiView protein in Pfam
PF00352. TBP. 2 hits.
PRINTSiPR00686. TIFACTORIID.
PROSITEiView protein in PROSITE
PS00351. TFIID. 2 hits.

Sequencei

Sequence statusi: Complete.

Q28GG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNNSIPPF QGLASPQGSL TPGINIFSPL MPYGTGLTPQ PVQTTNSLSI
60 70 80 90 100
LEEQQRQQQQ AQQSTSQQGN QGSGQTPQLF HPQTLTTAPL PGNTPLYPSP
110 120 130 140 150
MTPMTPITPA TPASESSGIV PQLQNIVSTV NLGCKLDLKT IALRARNAEY
160 170 180 190 200
NPKRFAAVIM RIREPRTTAL IFSSGKMVCT GAKSEEQSRL AARKYARVVQ
210 220 230 240 250
KLGFPAKFLD FKIQNMVGSC DVKFPIRLEG LVLTHQQFSS YEPELFPGLI
260 270 280 290
YRMIKPRIVL LIFVSGKVVL TGAKVRAEIY EAFENIYPIL KGFRKTT
Length:297
Mass (Da):32,693
Last modified:April 4, 2006 - v1
Checksum:i0CBF63B82EEA1A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761393 mRNA. Translation: CAJ83650.1.
BC160510 mRNA. Translation: AAI60510.1.
RefSeqiNP_001016339.1. NM_001016339.3.
XP_012818447.1. XM_012962993.2.
UniGeneiStr.6374.

Genome annotation databases

GeneIDi549093.
KEGGixtr:549093.

Similar proteinsi

Entry informationi

Entry nameiTBP_XENTR
AccessioniPrimary (citable) accession number: Q28GG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 4, 2006
Last modified: August 30, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families