Reviewed, UniProtKB/Swiss-Prot Q28G26 (P4K2B_XENTR)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol 4-kinase type 2-beta
    EC=2.7.1.67
Alternative name(s):
    Phosphatidylinositol 4-kinase type II-beta

Gene names

Name:	pi4k2b
ORF Names:	TGas067g11.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity. Plays a role in the phosphorylation of phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). Involved in the regulation of vesicular membrane trafficking By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Subcellular location	Cytoplasm By similarity. Membrane By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-phosphatidylinositol 4-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Phosphatidylinositol 4-kinase type 2-beta		PRO_0000285170
Regions
	Domain	136 – 447	312	PI3K/PI4K
	Compositional bias	86 – 89	4	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q28G26-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: A6DD5C61D7734092	FASTA	492	55,770
	10 20 30 40 50 60 MEPKQTADAR DSPPLLVFLE PAAEEVTAHT APLSPNPQSA RAAPGSAVRF FSDSAREEEA 70 80 90 100 110 120 GEDEPLLKKS GPVSPRAARK GRTRLSSSSD RENMSGGHVG NGEFNVILDD LEFADIIHRA 130 140 150 160 170 180 EQAIESGVFP ERISQGSSGS YFVKDPKGKI IGVFKPKSEE PYGHLNPKWT KYFHKICCPC 190 200 210 220 230 240 CFGRGCLVPN QGYLSEAGAY LVDEKLGLGV VPKTKVVWLV SETFNYSAID RAKSRGKKYA 250 260 270 280 290 300 LEKVPKVGRK FHRIGLPPKV GSFQLFVDGY KEADYWLRKF ETDPLPENTR KQLQCQFEKL 310 320 330 340 350 360 VILDYVIRNT DRGNDNWLIR YDSQDDDELM EKGDDFPLKD WKEIKEPVIK IAAIDNGLAF 370 380 390 400 410 420 PFKHPDEWRA YPFHWAWLPQ AKVPFSQETR DLILPRISDM NFVQDLCEDL YELFKTDKGF 430 440 450 460 470 480 DKATFEKQMS VMRGQILNLT QALKDGKTPI QLVQMPRVVV ERSCSGSQGR IVQMSNAFTQ 490 TFHCRKPFFS SW

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastrula.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR761607 mRNA. Translation: CAJ83481.1.
RefSeq	NP_001016953.1.
UniGene	Str.7163
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	549707.
KEGG	xtr:549707.
Organism-specific databases
CTD	549707.
Xenbase	XB-FEAT-974292. pi4k2b.
Phylogenomic databases
HOVERGEN	Q28G26.
Enzyme and pathway databases
BRENDA	2.7.1.67. 279072.
Family and domain databases
InterPro	IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. [Graphical view]
Pfam	PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
PROSITE	PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. False negative. PS50290. PI3_4_KINASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P4K2B_XENTR

Accession

Primary (citable) accession number: Q28G26

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	April 4, 2006
Last modified:	September 1, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project