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Protein

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene

hibch

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity).By similarity

Catalytic activityi

3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

Pathway:iL-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201SubstrateBy similarity
Binding sitei145 – 1451Substrate; via amide nitrogenBy similarity
Binding sitei168 – 1681SubstrateBy similarity
Binding sitei176 – 1761SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Branched-chain amino acid catabolism

Enzyme and pathway databases

ReactomeiREACT_285161. Branched-chain amino acid catabolism.
UniPathwayiUPA00362.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
Alternative name(s):
3-hydroxyisobutyryl-coenzyme A hydrolase
Short name:
HIB-CoA hydrolase
Short name:
HIBYL-CoA-H
Gene namesi
Name:hibch
ORF Names:TGas039e14.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-947696. hibch.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284934
Transit peptidei1 – ?MitochondrionSequence Analysis

Expressioni

Gene expression databases

BgeeiQ28FR6.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000033364.

Structurei

3D structure databases

ProteinModelPortaliQ28FR6.
SMRiQ28FR6. Positions 36-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00570000079226.
HOGENOMiHOG000217005.
HOVERGENiHBG054809.
InParanoidiQ28FR6.
KOiK05605.
OMAiCVPSSWL.
OrthoDBiEOG7H1JKT.
TreeFamiTF314329.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28FR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGLLESQL RLKVFGRLQV IRQHLRMTNH TVKDGECLLT KAGCAGVITL
60 70 80 90 100
NRPKALNALN LGMIRLIYPQ LGLWEEDPET YLVIIKGVGG KAFCAGGDIR
110 120 130 140 150
AVTDAGKAGD RLAQDFFREE YILNNAIGTY KKPYVALIDG ITMGGGVGLS
160 170 180 190 200
VHGHFRVASE NTLFAMPETA IGLFPDVGGG YFLPRLPGKL GLYLALTGFR
210 220 230 240 250
LKGSDVQKAG IATHFVESEK IPSLEQDLVA MKCPSKENVA DVLDSYHNKS
260 270 280 290 300
YAAQDKPFVL AEHLDKINSL FSASSVEAII ENLRCDGSSF ALKQLQTLST
310 320 330 340 350
MSPTSLKITF RQLKEGSSMS LQEVLTMEYR LSQACMKGYD FYEGVRAVLI
360 370 380
DKNQNAKWNP ELLEEVTDDY IDSYFTSLGN SDLKL
Length:385
Mass (Da):42,336
Last modified:April 4, 2006 - v1
Checksum:iE6F215988E93D686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761811 mRNA. Translation: CAJ81517.1.
BC157188 mRNA. Translation: AAI57189.1.
RefSeqiNP_001016188.1. NM_001016188.2.
UniGeneiStr.26857.

Genome annotation databases

EnsembliENSXETT00000033364; ENSXETP00000033364; ENSXETG00000015247.
GeneIDi548942.
KEGGixtr:548942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761811 mRNA. Translation: CAJ81517.1.
BC157188 mRNA. Translation: AAI57189.1.
RefSeqiNP_001016188.1. NM_001016188.2.
UniGeneiStr.26857.

3D structure databases

ProteinModelPortaliQ28FR6.
SMRiQ28FR6. Positions 36-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000033364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000033364; ENSXETP00000033364; ENSXETG00000015247.
GeneIDi548942.
KEGGixtr:548942.

Organism-specific databases

CTDi26275.
XenbaseiXB-GENE-947696. hibch.

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00570000079226.
HOGENOMiHOG000217005.
HOVERGENiHBG054809.
InParanoidiQ28FR6.
KOiK05605.
OMAiCVPSSWL.
OrthoDBiEOG7H1JKT.
TreeFamiTF314329.

Enzyme and pathway databases

UniPathwayiUPA00362.
ReactomeiREACT_285161. Branched-chain amino acid catabolism.

Gene expression databases

BgeeiQ28FR6.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiHIBCH_XENTR
AccessioniPrimary (citable) accession number: Q28FR6
Secondary accession number(s): A9ULB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 4, 2006
Last modified: May 27, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.