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Q28FR6 (HIBCH_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
EC=3.1.2.4
Alternative name(s):
3-hydroxyisobutyryl-coenzyme A hydrolase
Short name=HIB-CoA hydrolase
Short name=HIBYL-CoA-H
Gene names
Name:hibch
ORF Names:TGas039e14.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA By similarity.

Catalytic activity

3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

Pathway

Amino-acid degradation; L-valine degradation.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
   Biological processBranched-chain amino acid catabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processvaline catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyisobutyryl-CoA hydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284934

Sites

Binding site1201Substrate By similarity
Binding site1451Substrate; via amide nitrogen By similarity
Binding site1681Substrate By similarity
Binding site1761Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28FR6 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: E6F215988E93D686

FASTA38542,336
        10         20         30         40         50         60 
MSLGLLESQL RLKVFGRLQV IRQHLRMTNH TVKDGECLLT KAGCAGVITL NRPKALNALN 

        70         80         90        100        110        120 
LGMIRLIYPQ LGLWEEDPET YLVIIKGVGG KAFCAGGDIR AVTDAGKAGD RLAQDFFREE 

       130        140        150        160        170        180 
YILNNAIGTY KKPYVALIDG ITMGGGVGLS VHGHFRVASE NTLFAMPETA IGLFPDVGGG 

       190        200        210        220        230        240 
YFLPRLPGKL GLYLALTGFR LKGSDVQKAG IATHFVESEK IPSLEQDLVA MKCPSKENVA 

       250        260        270        280        290        300 
DVLDSYHNKS YAAQDKPFVL AEHLDKINSL FSASSVEAII ENLRCDGSSF ALKQLQTLST 

       310        320        330        340        350        360 
MSPTSLKITF RQLKEGSSMS LQEVLTMEYR LSQACMKGYD FYEGVRAVLI DKNQNAKWNP 

       370        380 
ELLEEVTDDY IDSYFTSLGN SDLKL

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR761811 mRNA. Translation: CAJ81517.1.
BC157188 mRNA. Translation: AAI57189.1.
RefSeqNP_001016188.1. NM_001016188.2.
UniGeneStr.26857.

3D structure databases

ProteinModelPortalQ28FR6.
SMRQ28FR6. Positions 36-385.
ModBaseSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000033364.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000033364; ENSXETP00000033364; ENSXETG00000015247.
GeneID548942.
KEGGxtr:548942.

Organism-specific databases

CTD26275.
XenbaseXB-GENE-947696. hibch.

Phylogenomic databases

eggNOGCOG1024.
GeneTreeENSGT00570000079226.
HOGENOMHOG000217005.
HOVERGENHBG054809.
KOK05605.
OMAYHVPSEQ.
OrthoDBEOG4G7BZM.

Enzyme and pathway databases

UniPathwayUPA00362.

Gene expression databases

BgeeQ28FR6.

Family and domain databases

Gene3D1.10.12.10. 1 hit.
InterProIPR014748. Crontonase_C.
[Graphical view]
PROSITEPS00166. ENOYL_COA_HYDRATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIBCH_XENTR
AccessionPrimary (citable) accession number: Q28FR6
Secondary accession number(s): A9ULB0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 4, 2006
Last modified: April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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