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Q28FR6

- HIBCH_XENTR

UniProt

Q28FR6 - HIBCH_XENTR

Protein

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene

hibch

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA By similarity.By similarity

    Catalytic activityi

    3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201SubstrateBy similarity
    Binding sitei145 – 1451Substrate; via amide nitrogenBy similarity
    Binding sitei168 – 1681SubstrateBy similarity
    Binding sitei176 – 1761SubstrateBy similarity

    GO - Molecular functioni

    1. 3-hydroxyisobutyryl-CoA hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. valine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Branched-chain amino acid catabolism

    Enzyme and pathway databases

    UniPathwayiUPA00362.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
    Alternative name(s):
    3-hydroxyisobutyryl-coenzyme A hydrolase
    Short name:
    HIB-CoA hydrolase
    Short name:
    HIBYL-CoA-H
    Gene namesi
    Name:hibch
    ORF Names:TGas039e14.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-947696. hibch.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284934
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Expressioni

    Gene expression databases

    BgeeiQ28FR6.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000033364.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28FR6.
    SMRiQ28FR6. Positions 36-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1024.
    GeneTreeiENSGT00570000079226.
    HOGENOMiHOG000217005.
    HOVERGENiHBG054809.
    KOiK05605.
    OMAiYNSAREG.
    OrthoDBiEOG7H1JKT.
    TreeFamiTF314329.

    Family and domain databases

    Gene3Di1.10.12.10. 1 hit.
    3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR014748. Crontonase_C.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28FR6-1 [UniParc]FASTAAdd to Basket

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    MSLGLLESQL RLKVFGRLQV IRQHLRMTNH TVKDGECLLT KAGCAGVITL    50
    NRPKALNALN LGMIRLIYPQ LGLWEEDPET YLVIIKGVGG KAFCAGGDIR 100
    AVTDAGKAGD RLAQDFFREE YILNNAIGTY KKPYVALIDG ITMGGGVGLS 150
    VHGHFRVASE NTLFAMPETA IGLFPDVGGG YFLPRLPGKL GLYLALTGFR 200
    LKGSDVQKAG IATHFVESEK IPSLEQDLVA MKCPSKENVA DVLDSYHNKS 250
    YAAQDKPFVL AEHLDKINSL FSASSVEAII ENLRCDGSSF ALKQLQTLST 300
    MSPTSLKITF RQLKEGSSMS LQEVLTMEYR LSQACMKGYD FYEGVRAVLI 350
    DKNQNAKWNP ELLEEVTDDY IDSYFTSLGN SDLKL 385
    Length:385
    Mass (Da):42,336
    Last modified:April 4, 2006 - v1
    Checksum:iE6F215988E93D686
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761811 mRNA. Translation: CAJ81517.1.
    BC157188 mRNA. Translation: AAI57189.1.
    RefSeqiNP_001016188.1. NM_001016188.2.
    UniGeneiStr.26857.

    Genome annotation databases

    EnsembliENSXETT00000033364; ENSXETP00000033364; ENSXETG00000015247.
    GeneIDi548942.
    KEGGixtr:548942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761811 mRNA. Translation: CAJ81517.1 .
    BC157188 mRNA. Translation: AAI57189.1 .
    RefSeqi NP_001016188.1. NM_001016188.2.
    UniGenei Str.26857.

    3D structure databases

    ProteinModelPortali Q28FR6.
    SMRi Q28FR6. Positions 36-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000033364.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000033364 ; ENSXETP00000033364 ; ENSXETG00000015247 .
    GeneIDi 548942.
    KEGGi xtr:548942.

    Organism-specific databases

    CTDi 26275.
    Xenbasei XB-GENE-947696. hibch.

    Phylogenomic databases

    eggNOGi COG1024.
    GeneTreei ENSGT00570000079226.
    HOGENOMi HOG000217005.
    HOVERGENi HBG054809.
    KOi K05605.
    OMAi YNSAREG.
    OrthoDBi EOG7H1JKT.
    TreeFami TF314329.

    Enzyme and pathway databases

    UniPathwayi UPA00362 .

    Gene expression databases

    Bgeei Q28FR6.

    Family and domain databases

    Gene3Di 1.10.12.10. 1 hit.
    3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR014748. Crontonase_C.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiHIBCH_XENTR
    AccessioniPrimary (citable) accession number: Q28FR6
    Secondary accession number(s): A9ULB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3