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Q28FR6

- HIBCH_XENTR

UniProt

Q28FR6 - HIBCH_XENTR

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Protein
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Gene
hibch, TGas039e14.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA By similarity.

Catalytic activityi

3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Substrate By similarity
Binding sitei145 – 1451Substrate; via amide nitrogen By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei176 – 1761Substrate By similarity

GO - Molecular functioni

  1. 3-hydroxyisobutyryl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. valine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Branched-chain amino acid catabolism

Enzyme and pathway databases

UniPathwayiUPA00362.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
Alternative name(s):
3-hydroxyisobutyryl-coenzyme A hydrolase
Short name:
HIB-CoA hydrolase
Short name:
HIBYL-CoA-H
Gene namesi
Name:hibch
ORF Names:TGas039e14.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-947696. hibch.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284934
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Expressioni

Gene expression databases

BgeeiQ28FR6.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000033364.

Structurei

3D structure databases

ProteinModelPortaliQ28FR6.
SMRiQ28FR6. Positions 36-385.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00570000079226.
HOGENOMiHOG000217005.
HOVERGENiHBG054809.
KOiK05605.
OMAiYNSAREG.
OrthoDBiEOG7H1JKT.
TreeFamiTF314329.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28FR6-1 [UniParc]FASTAAdd to Basket

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MSLGLLESQL RLKVFGRLQV IRQHLRMTNH TVKDGECLLT KAGCAGVITL    50
NRPKALNALN LGMIRLIYPQ LGLWEEDPET YLVIIKGVGG KAFCAGGDIR 100
AVTDAGKAGD RLAQDFFREE YILNNAIGTY KKPYVALIDG ITMGGGVGLS 150
VHGHFRVASE NTLFAMPETA IGLFPDVGGG YFLPRLPGKL GLYLALTGFR 200
LKGSDVQKAG IATHFVESEK IPSLEQDLVA MKCPSKENVA DVLDSYHNKS 250
YAAQDKPFVL AEHLDKINSL FSASSVEAII ENLRCDGSSF ALKQLQTLST 300
MSPTSLKITF RQLKEGSSMS LQEVLTMEYR LSQACMKGYD FYEGVRAVLI 350
DKNQNAKWNP ELLEEVTDDY IDSYFTSLGN SDLKL 385
Length:385
Mass (Da):42,336
Last modified:April 4, 2006 - v1
Checksum:iE6F215988E93D686
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761811 mRNA. Translation: CAJ81517.1.
BC157188 mRNA. Translation: AAI57189.1.
RefSeqiNP_001016188.1. NM_001016188.2.
UniGeneiStr.26857.

Genome annotation databases

EnsembliENSXETT00000033364; ENSXETP00000033364; ENSXETG00000015247.
GeneIDi548942.
KEGGixtr:548942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761811 mRNA. Translation: CAJ81517.1 .
BC157188 mRNA. Translation: AAI57189.1 .
RefSeqi NP_001016188.1. NM_001016188.2.
UniGenei Str.26857.

3D structure databases

ProteinModelPortali Q28FR6.
SMRi Q28FR6. Positions 36-385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000033364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000033364 ; ENSXETP00000033364 ; ENSXETG00000015247 .
GeneIDi 548942.
KEGGi xtr:548942.

Organism-specific databases

CTDi 26275.
Xenbasei XB-GENE-947696. hibch.

Phylogenomic databases

eggNOGi COG1024.
GeneTreei ENSGT00570000079226.
HOGENOMi HOG000217005.
HOVERGENi HBG054809.
KOi K05605.
OMAi YNSAREG.
OrthoDBi EOG7H1JKT.
TreeFami TF314329.

Enzyme and pathway databases

UniPathwayi UPA00362 .

Gene expression databases

Bgeei Q28FR6.

Family and domain databases

Gene3Di 1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiHIBCH_XENTR
AccessioniPrimary (citable) accession number: Q28FR6
Secondary accession number(s): A9ULB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 4, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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