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Q28FQ6 (ARHL2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Poly(ADP-ribose) glycohydrolase ARH3
EC=3.2.1.143
Alternative name(s):
ADP-ribosylhydrolase 3
[Protein ADP-ribosylarginine] hydrolase-like protein 2
Gene names
Name:adprhl2
Synonyms:arh3
ORF Names:TGas084j22.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds By similarity.

Catalytic activity

Hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

poly(ADP-ribose) glycohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Poly(ADP-ribose) glycohydrolase ARH3
PRO_0000277617

Sites

Metal binding271Magnesium 2 By similarity
Metal binding571Magnesium 1 By similarity
Metal binding581Magnesium 1 By similarity
Metal binding591Magnesium 1 By similarity
Metal binding2951Magnesium 2 By similarity
Metal binding2971Magnesium 1 By similarity
Metal binding2971Magnesium 2 By similarity
Metal binding2981Magnesium 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28FQ6 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 7AACCDD9CDC767F6

FASTA35039,034
        10         20         30         40         50         60 
MMAAGVSRFR GSLLGALLGD CIGAVFEGHT NVTKEFLFDY MKSLDKGERL KRVLTYTDDT 

        70         80         90        100        110        120 
AMARSIVQSV LENYEFNIED LANRFTTEYN RDPDRGYGMA VVHVFEKLGS GEYKHVFSPA 

       130        140        150        160        170        180 
REQFDGKGSY GNGAAMRVVG ISLAYPRIPD IIEYARTSGM LTHASSLGYN GAILQALAVH 

       190        200        210        220        230        240 
YALQGELAPE TFLDQLLDHM KEVETDKKSR SDALELEMDE FPYCNKLRKI KAFLAREDVT 

       250        260        270        280        290        300 
RKDIVKELGN GIQAFESVPT AIYSFLRCLK PVSELPSELT NLQRTIAFCI LLGGDTDTIA 

       310        320        330        340        350 
TMAAAIAGAY HGEEQIPLNW KLSAEGYKDA EDWGEKLHQL YCRRLQSTTS

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR761827 mRNA. Translation: CAJ81573.1.
RefSeqNP_001016184.1. NM_001016184.2.
UniGeneStr.3494.

3D structure databases

ProteinModelPortalQ28FQ6.
SMRQ28FQ6. Positions 5-343.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID548938.
KEGGxtr:548938.

Organism-specific databases

CTD54936.
XenbaseXB-GENE-944445. adprhl2.

Phylogenomic databases

GeneTreeENSGT00390000015369.
HOVERGENHBG080863.

Gene expression databases

BgeeQ28FQ6.

Family and domain databases

InterProIPR005502. Ribosyl_crysJ1.
[Graphical view]
KOK11687.
PfamPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
SUPFAMSSF101478. Ribosyl_crysJ1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARHL2_XENTR
AccessionPrimary (citable) accession number: Q28FQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 4, 2006
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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