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Q28FD1

- AK1A1_XENTR

UniProt

Q28FD1 - AK1A1_XENTR

Protein

Alcohol dehydrogenase [NADP(+)]

Gene

akr1a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.By similarity

    Catalytic activityi

    An alcohol + NADP+ = an aldehyde + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521Proton donorBy similarity
    Sitei82 – 821Lowers pKa of active site TyrBy similarity
    Binding sitei115 – 1151SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi213 – 27563NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. alcohol dehydrogenase (NADP+) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2)
    Alternative name(s):
    Aldehyde reductase
    Aldo-keto reductase family 1 member A1
    Gene namesi
    Name:akr1a1
    ORF Names:TEgg056i02.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1014353. akr1a1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Alcohol dehydrogenase [NADP(+)]PRO_0000384155Add
    BLAST

    Proteomic databases

    PaxDbiQ28FD1.

    Expressioni

    Gene expression databases

    BgeeiQ28FD1.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000007570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28FD1.
    SMRiQ28FD1. Positions 10-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG0656.
    GeneTreeiENSGT00750000117547.
    HOGENOMiHOG000250272.
    KOiK00002.
    OMAiTAVEYET.
    OrthoDBiEOG70KGQF.
    TreeFamiTF106492.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28FD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAVEYETL YTGQKIPLIG LGTWKSAPGQ VKDAVKYALG VGYRHIDCAF    50
    VYGNETEVGE AIKESVGSDK GLSREEVFVT SKLWNNKHHP DDVECALRKT 100
    LQDLQLDYLD LYLMHWPYAF KRGDQIFPQN PDGSVQYDLT DYKDTWKAME 150
    KLVKQGLTKA IGLSNFNKRQ IDDIISIATV KPAVLQVECH PYLAQNELIA 200
    YCHAHGLVFT GYSPLGSPDR SWRKPEDPVL LEEPGIIAMA KKYGKSEAQI 250
    LLRWQVQRKV VSIPKSVTPT RILQNFQVFD FSLSEEEMQL IGALNKNWRY 300
    IIPLITVNGK SVPRDAGHPL YPFNDPY 327
    Length:327
    Mass (Da):37,064
    Last modified:April 4, 2006 - v1
    Checksum:i8B5CB49726E4FBCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR762028 mRNA. Translation: CAJ81495.1.
    BC170750 mRNA. Translation: AAI70750.1.
    BC170752 mRNA. Translation: AAI70752.1.
    RefSeqiNP_001016137.1. NM_001016137.2.
    UniGeneiStr.11963.

    Genome annotation databases

    EnsembliENSXETT00000007570; ENSXETP00000007570; ENSXETG00000003499.
    GeneIDi548891.
    KEGGixtr:548891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR762028 mRNA. Translation: CAJ81495.1 .
    BC170750 mRNA. Translation: AAI70750.1 .
    BC170752 mRNA. Translation: AAI70752.1 .
    RefSeqi NP_001016137.1. NM_001016137.2.
    UniGenei Str.11963.

    3D structure databases

    ProteinModelPortali Q28FD1.
    SMRi Q28FD1. Positions 10-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000007570.

    Proteomic databases

    PaxDbi Q28FD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000007570 ; ENSXETP00000007570 ; ENSXETG00000003499 .
    GeneIDi 548891.
    KEGGi xtr:548891.

    Organism-specific databases

    CTDi 10327.
    Xenbasei XB-GENE-1014353. akr1a1.

    Phylogenomic databases

    eggNOGi COG0656.
    GeneTreei ENSGT00750000117547.
    HOGENOMi HOG000250272.
    KOi K00002.
    OMAi TAVEYET.
    OrthoDBi EOG70KGQF.
    TreeFami TF106492.

    Gene expression databases

    Bgeei Q28FD1.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neurula.

    Entry informationi

    Entry nameiAK1A1_XENTR
    AccessioniPrimary (citable) accession number: Q28FD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3