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Protein

Alcohol dehydrogenase [NADP(+)]

Gene

akr1a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).By similarity

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton donorBy similarity
Sitei82 – 821Lowers pKa of active site TyrBy similarity
Binding sitei115 – 1151SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 27563NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. alcohol dehydrogenase (NADP+) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2)
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene namesi
Name:akr1a1
ORF Names:TEgg056i02.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1014353. akr1a1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Alcohol dehydrogenase [NADP(+)]PRO_0000384155Add
BLAST

Proteomic databases

PaxDbiQ28FD1.

Expressioni

Gene expression databases

BgeeiQ28FD1.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007570.

Structurei

3D structure databases

ProteinModelPortaliQ28FD1.
SMRiQ28FD1. Positions 10-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiCOG0656.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
InParanoidiQ28FD1.
KOiK00002.
OMAiTAVEYET.
OrthoDBiEOG70KGQF.
TreeFamiTF106492.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28FD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAVEYETL YTGQKIPLIG LGTWKSAPGQ VKDAVKYALG VGYRHIDCAF
60 70 80 90 100
VYGNETEVGE AIKESVGSDK GLSREEVFVT SKLWNNKHHP DDVECALRKT
110 120 130 140 150
LQDLQLDYLD LYLMHWPYAF KRGDQIFPQN PDGSVQYDLT DYKDTWKAME
160 170 180 190 200
KLVKQGLTKA IGLSNFNKRQ IDDIISIATV KPAVLQVECH PYLAQNELIA
210 220 230 240 250
YCHAHGLVFT GYSPLGSPDR SWRKPEDPVL LEEPGIIAMA KKYGKSEAQI
260 270 280 290 300
LLRWQVQRKV VSIPKSVTPT RILQNFQVFD FSLSEEEMQL IGALNKNWRY
310 320
IIPLITVNGK SVPRDAGHPL YPFNDPY
Length:327
Mass (Da):37,064
Last modified:April 4, 2006 - v1
Checksum:i8B5CB49726E4FBCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762028 mRNA. Translation: CAJ81495.1.
BC170750 mRNA. Translation: AAI70750.1.
BC170752 mRNA. Translation: AAI70752.1.
RefSeqiNP_001016137.1. NM_001016137.2.
UniGeneiStr.11963.

Genome annotation databases

EnsembliENSXETT00000007570; ENSXETP00000007570; ENSXETG00000003499.
GeneIDi548891.
KEGGixtr:548891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762028 mRNA. Translation: CAJ81495.1.
BC170750 mRNA. Translation: AAI70750.1.
BC170752 mRNA. Translation: AAI70752.1.
RefSeqiNP_001016137.1. NM_001016137.2.
UniGeneiStr.11963.

3D structure databases

ProteinModelPortaliQ28FD1.
SMRiQ28FD1. Positions 10-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007570.

Proteomic databases

PaxDbiQ28FD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000007570; ENSXETP00000007570; ENSXETG00000003499.
GeneIDi548891.
KEGGixtr:548891.

Organism-specific databases

CTDi10327.
XenbaseiXB-GENE-1014353. akr1a1.

Phylogenomic databases

eggNOGiCOG0656.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
InParanoidiQ28FD1.
KOiK00002.
OMAiTAVEYET.
OrthoDBiEOG70KGQF.
TreeFamiTF106492.

Gene expression databases

BgeeiQ28FD1.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.

Entry informationi

Entry nameiAK1A1_XENTR
AccessioniPrimary (citable) accession number: Q28FD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 4, 2006
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.