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Q28FD1 (AK1A1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase [NADP(+)]

EC=1.1.1.2
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene names
Name:akr1a1
ORF Names:TEgg056i02.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.

Catalytic activity

An alcohol + NADP+ = an aldehyde + NADPH.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionalcohol dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Alcohol dehydrogenase [NADP(+)]
PRO_0000384155

Regions

Nucleotide binding213 – 27563NADP By similarity

Sites

Active site521Proton donor By similarity
Binding site1151Substrate By similarity
Site821Lowers pKa of active site Tyr By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28FD1 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 8B5CB49726E4FBCC

FASTA32737,064
        10         20         30         40         50         60 
MATAVEYETL YTGQKIPLIG LGTWKSAPGQ VKDAVKYALG VGYRHIDCAF VYGNETEVGE 

        70         80         90        100        110        120 
AIKESVGSDK GLSREEVFVT SKLWNNKHHP DDVECALRKT LQDLQLDYLD LYLMHWPYAF 

       130        140        150        160        170        180 
KRGDQIFPQN PDGSVQYDLT DYKDTWKAME KLVKQGLTKA IGLSNFNKRQ IDDIISIATV 

       190        200        210        220        230        240 
KPAVLQVECH PYLAQNELIA YCHAHGLVFT GYSPLGSPDR SWRKPEDPVL LEEPGIIAMA 

       250        260        270        280        290        300 
KKYGKSEAQI LLRWQVQRKV VSIPKSVTPT RILQNFQVFD FSLSEEEMQL IGALNKNWRY 

       310        320 
IIPLITVNGK SVPRDAGHPL YPFNDPY 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neurula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR762028 mRNA. Translation: CAJ81495.1.
BC170750 mRNA. Translation: AAI70750.1.
BC170752 mRNA. Translation: AAI70752.1.
RefSeqNP_001016137.1. NM_001016137.2.
UniGeneStr.11963.

3D structure databases

ProteinModelPortalQ28FD1.
SMRQ28FD1. Positions 10-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000007570.

Proteomic databases

PaxDbQ28FD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000007570; ENSXETP00000007570; ENSXETG00000003499.
GeneID548891.
KEGGxtr:548891.

Organism-specific databases

CTD10327.
XenbaseXB-GENE-1014353. akr1a1.

Phylogenomic databases

eggNOGCOG0656.
GeneTreeENSGT00750000117547.
HOGENOMHOG000250272.
KOK00002.
OMASEEMAMI.
OrthoDBEOG70KGQF.
TreeFamTF106492.

Gene expression databases

BgeeQ28FD1.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAK1A1_XENTR
AccessionPrimary (citable) accession number: Q28FD1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families