Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q28FC1 (UBE2W_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 W

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein W
Ubiquitin-protein ligase W
Gene names
Name:ube2w
ORF Names:TEgg096e02.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 151151Ubiquitin-conjugating enzyme E2 W
PRO_0000416882

Sites

Active site911Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28FC1 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: B91B585BBD091F34

FASTA15117,331
        10         20         30         40         50         60 
MASMQKRLQK ELLALQNEPP PGMTLNEKSV QNSITQWIVD MEGAPGTLYE GEKFQLLFKF 

        70         80         90        100        110        120 
SSRYPFDSPQ VMFTGDNIPV HPHVYSNGHI CLSILTEDWS PALSVQSVCL SIISMLSSCK 

       130        140        150 
EKRRPPDNSF YVRTCNKNPK KTKWWYHDDT C 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR762043 mRNA. Translation: CAJ83690.1.
RefSeqNP_001016132.1. NM_001016132.2.
UniGeneStr.19999.

3D structure databases

ProteinModelPortalQ28FC1.
SMRQ28FC1. Positions 1-117.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID548886.
KEGGxtr:548886.

Organism-specific databases

CTD55284.
XenbaseXB-GENE-954746. ube2w.

Phylogenomic databases

HOVERGENHBG063308.
KOK10688.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2W_XENTR
AccessionPrimary (citable) accession number: Q28FC1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 4, 2006
Last modified: January 22, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways