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Q28F89

- UBE2S_XENTR

UniProt

Q28F89 - UBE2S_XENTR

Protein

Ubiquitin-conjugating enzyme E2 S

Gene

ube2s

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of anaphase-promoting complex activity Source: UniProtKB
    2. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    3. exit from mitosis Source: UniProtKB
    4. free ubiquitin chain polymerization Source: UniProtKB
    5. protein K11-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein S
    Ubiquitin-protein ligase S
    Gene namesi
    Name:ube2s
    ORF Names:TEgg003m12.1, TEgg028l19.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1008017. ube2s.

    Subcellular locationi

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Ubiquitin-conjugating enzyme E2 SPRO_0000390434Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ28F89.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000000266.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28F89.
    SMRiQ28F89. Positions 6-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00730000110565.
    HOGENOMiHOG000233455.
    HOVERGENiHBG063308.
    KOiK10583.
    OMAiQICADIE.
    OrthoDBiEOG73JKXD.
    TreeFamiTF101120.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28F89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSNVENLPP HIIRQVYKEV STLTSDPPEG IKIIPNEEDI TDVQVNIEGP    50
    EGTPYAGGIF RMKLILGKDF PAAPPKGYFL TKIFHPNVST NGEICVNVLK 100
    KDWKAELGIR HVLLTIKCLL IHPNPESALN EEAGRLLLEN YEEYASRARL 150
    MTEIHAQGSS LRGKDPTDPC SSASATLVSG DGPMAKKHAG DRDKKLAAKK 200
    KTDKKRALRR L 211
    Length:211
    Mass (Da):23,288
    Last modified:April 4, 2006 - v1
    Checksum:i49818D7A14991D62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761031 mRNA. Translation: CAJ83662.1.
    CR761379 mRNA. Translation: CAJ82166.1.
    CR762108 mRNA. Translation: CAJ81686.1.
    BC170651 mRNA. Translation: AAI70651.1.
    BC170653 mRNA. Translation: AAI70653.1.
    RefSeqiNP_001016438.1. NM_001016438.2.
    UniGeneiStr.6451.

    Genome annotation databases

    EnsembliENSXETT00000064784; ENSXETP00000063683; ENSXETG00000000138.
    GeneIDi549192.
    KEGGixtr:549192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761031 mRNA. Translation: CAJ83662.1 .
    CR761379 mRNA. Translation: CAJ82166.1 .
    CR762108 mRNA. Translation: CAJ81686.1 .
    BC170651 mRNA. Translation: AAI70651.1 .
    BC170653 mRNA. Translation: AAI70653.1 .
    RefSeqi NP_001016438.1. NM_001016438.2.
    UniGenei Str.6451.

    3D structure databases

    ProteinModelPortali Q28F89.
    SMRi Q28F89. Positions 6-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000000266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000064784 ; ENSXETP00000063683 ; ENSXETG00000000138 .
    GeneIDi 549192.
    KEGGi xtr:549192.

    Organism-specific databases

    CTDi 27338.
    Xenbasei XB-GENE-1008017. ube2s.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00730000110565.
    HOGENOMi HOG000233455.
    HOVERGENi HBG063308.
    KOi K10583.
    OMAi QICADIE.
    OrthoDBi EOG73JKXD.
    TreeFami TF101120.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Gene expression databases

    Bgeei Q28F89.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neurula.

    Entry informationi

    Entry nameiUBE2S_XENTR
    AccessioniPrimary (citable) accession number: Q28F89
    Secondary accession number(s): Q28GI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3