SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q28F89

- UBE2S_XENTR

UniProt

Q28F89 - UBE2S_XENTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ubiquitin-conjugating enzyme E2 S
Gene
ube2s, TEgg003m12.1, TEgg028l19.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. activation of anaphase-promoting complex activity Source: UniProtKB
  2. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  3. exit from mitosis Source: UniProtKB
  4. free ubiquitin chain polymerization Source: UniProtKB
  5. protein K11-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 S (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene namesi
Name:ube2s
ORF Names:TEgg003m12.1, TEgg028l19.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1008017. ube2s.

Subcellular locationi

GO - Cellular componenti

  1. anaphase-promoting complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Ubiquitin-conjugating enzyme E2 S
PRO_0000390434Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28F89.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000266.

Structurei

3D structure databases

ProteinModelPortaliQ28F89.
SMRiQ28F89. Positions 6-156.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110565.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
KOiK10583.
OMAiQICADIE.
OrthoDBiEOG73JKXD.
TreeFamiTF101120.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28F89-1 [UniParc]FASTAAdd to Basket

« Hide

MNSNVENLPP HIIRQVYKEV STLTSDPPEG IKIIPNEEDI TDVQVNIEGP    50
EGTPYAGGIF RMKLILGKDF PAAPPKGYFL TKIFHPNVST NGEICVNVLK 100
KDWKAELGIR HVLLTIKCLL IHPNPESALN EEAGRLLLEN YEEYASRARL 150
MTEIHAQGSS LRGKDPTDPC SSASATLVSG DGPMAKKHAG DRDKKLAAKK 200
KTDKKRALRR L 211
Length:211
Mass (Da):23,288
Last modified:April 4, 2006 - v1
Checksum:i49818D7A14991D62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761031 mRNA. Translation: CAJ83662.1.
CR761379 mRNA. Translation: CAJ82166.1.
CR762108 mRNA. Translation: CAJ81686.1.
BC170651 mRNA. Translation: AAI70651.1.
BC170653 mRNA. Translation: AAI70653.1.
RefSeqiNP_001016438.1. NM_001016438.2.
UniGeneiStr.6451.

Genome annotation databases

EnsembliENSXETT00000064784; ENSXETP00000063683; ENSXETG00000000138.
GeneIDi549192.
KEGGixtr:549192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761031 mRNA. Translation: CAJ83662.1 .
CR761379 mRNA. Translation: CAJ82166.1 .
CR762108 mRNA. Translation: CAJ81686.1 .
BC170651 mRNA. Translation: AAI70651.1 .
BC170653 mRNA. Translation: AAI70653.1 .
RefSeqi NP_001016438.1. NM_001016438.2.
UniGenei Str.6451.

3D structure databases

ProteinModelPortali Q28F89.
SMRi Q28F89. Positions 6-156.
ModBasei Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000000266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000064784 ; ENSXETP00000063683 ; ENSXETG00000000138 .
GeneIDi 549192.
KEGGi xtr:549192.

Organism-specific databases

CTDi 27338.
Xenbasei XB-GENE-1008017. ube2s.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110565.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
KOi K10583.
OMAi QICADIE.
OrthoDBi EOG73JKXD.
TreeFami TF101120.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Gene expression databases

Bgeei Q28F89.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.

Entry informationi

Entry nameiUBE2S_XENTR
AccessioniPrimary (citable) accession number: Q28F89
Secondary accession number(s): Q28GI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi