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Protein

Ubiquitin-conjugating enzyme E2 S

Gene

ube2s

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-XTR-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-XTR-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 S (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme S
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene namesi
Name:ube2s
ORF Names:TEgg003m12.1, TEgg028l19.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1008017 ube2s

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003904341 – 211Ubiquitin-conjugating enzyme E2 SAdd BLAST211

Proteomic databases

PaxDbiQ28F89

Expressioni

Gene expression databases

BgeeiENSXETG00000000138

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000063683

Structurei

3D structure databases

ProteinModelPortaliQ28F89
SMRiQ28F89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0423 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00900000140930
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ28F89
KOiK10583
OMAiGHKGEIC
OrthoDBiEOG091G0USF
TreeFamiTF101120

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q28F89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNVENLPP HIIRQVYKEV STLTSDPPEG IKIIPNEEDI TDVQVNIEGP
60 70 80 90 100
EGTPYAGGIF RMKLILGKDF PAAPPKGYFL TKIFHPNVST NGEICVNVLK
110 120 130 140 150
KDWKAELGIR HVLLTIKCLL IHPNPESALN EEAGRLLLEN YEEYASRARL
160 170 180 190 200
MTEIHAQGSS LRGKDPTDPC SSASATLVSG DGPMAKKHAG DRDKKLAAKK
210
KTDKKRALRR L
Length:211
Mass (Da):23,288
Last modified:April 4, 2006 - v1
Checksum:i49818D7A14991D62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761031 mRNA Translation: CAJ83662.1
CR761379 mRNA Translation: CAJ82166.1
CR762108 mRNA Translation: CAJ81686.1
BC170651 mRNA Translation: AAI70651.1
BC170653 mRNA Translation: AAI70653.1
RefSeqiNP_001016438.1, NM_001016438.2
UniGeneiStr.6451

Genome annotation databases

EnsembliENSXETT00000064784; ENSXETP00000063683; ENSXETG00000000138
GeneIDi549192
KEGGixtr:549192

Similar proteinsi

Entry informationi

Entry nameiUBE2S_XENTR
AccessioniPrimary (citable) accession number: Q28F89
Secondary accession number(s): Q28GI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health