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Q28F89 (UBE2S_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
Name:ube2s
ORF Names:TEgg003m12.1, TEgg028l19.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Ubiquitin-conjugating enzyme E2 S
PRO_0000390434

Sites

Active site951Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28F89 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 49818D7A14991D62

FASTA21123,288
        10         20         30         40         50         60 
MNSNVENLPP HIIRQVYKEV STLTSDPPEG IKIIPNEEDI TDVQVNIEGP EGTPYAGGIF 

        70         80         90        100        110        120 
RMKLILGKDF PAAPPKGYFL TKIFHPNVST NGEICVNVLK KDWKAELGIR HVLLTIKCLL 

       130        140        150        160        170        180 
IHPNPESALN EEAGRLLLEN YEEYASRARL MTEIHAQGSS LRGKDPTDPC SSASATLVSG 

       190        200        210 
DGPMAKKHAG DRDKKLAAKK KTDKKRALRR L 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neurula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR761031 mRNA. Translation: CAJ83662.1.
CR761379 mRNA. Translation: CAJ82166.1.
CR762108 mRNA. Translation: CAJ81686.1.
BC170651 mRNA. Translation: AAI70651.1.
BC170653 mRNA. Translation: AAI70653.1.
RefSeqNP_001016438.1. NM_001016438.2.
UniGeneStr.6451.

3D structure databases

ProteinModelPortalQ28F89.
SMRQ28F89. Positions 6-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000000266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000064784; ENSXETP00000063683; ENSXETG00000000138.
GeneID549192.
KEGGxtr:549192.

Organism-specific databases

CTD27338.
XenbaseXB-GENE-1008017. ube2s.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00730000110565.
HOGENOMHOG000233455.
HOVERGENHBG063308.
KOK10583.
OMAQICADIE.
OrthoDBEOG73JKXD.
TreeFamTF101120.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ28F89.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2S_XENTR
AccessionPrimary (citable) accession number: Q28F89
Secondary accession number(s): Q28GI1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways