Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q28EX9 (UBCP1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-like domain-containing CTD phosphatase 1

EC=3.1.3.16
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene names
Name:ublcp1
ORF Names:TGas135j05.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Magnesium By similarity.

Subcellular location

Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.

Domain

The Ubiquitin-like domain mediates interaction with proteasomes By similarity.

Sequence similarities

Contains 1 FCP1 homology domain.

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1
PRO_0000242647

Regions

Domain3 – 8179Ubiquitin-like
Domain133 – 294162FCP1 homology
Region133 – 294162Phosphatase By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28EX9 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 6544E1EF04FE4633

FASTA31836,854
        10         20         30         40         50         60 
MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY KGKPAENDVK 

        70         80         90        100        110        120 
LGVLKLKPNT KIMMMGTREE SLEEMMAPPP ENDEVVNDFD IEEEVVEVEN REENLAKISR 

       130        140        150        160        170        180 
RVKDYKIEIL NPPREGKKLL VLDVDYTLFD HRSCAETGQE LMRPYLHEFL TSAYEDYDIV 

       190        200        210        220        230        240 
IWSATSMKWI EAKMKELGVS TNSNYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG 

       250        260        270        280        290        300 
EFYNKNNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLSQY LKEIAQLDDL 

       310 
SELNHKHWER YLVKKQGQ 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR762286 mRNA. Translation: CAJ83586.1.
BC135735 mRNA. Translation: AAI35736.1.
RefSeqNP_001016061.1. NM_001016061.2.
UniGeneStr.13054.

3D structure databases

ProteinModelPortalQ28EX9.
SMRQ28EX9. Positions 3-79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000035725.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID548815.
KEGGxtr:548815.

Organism-specific databases

CTD134510.
XenbaseXB-GENE-5892709. ublcp1.

Phylogenomic databases

eggNOGNOG310886.
HOGENOMHOG000231279.
HOVERGENHBG080207.
KOK17618.

Gene expression databases

BgeeQ28EX9.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
[Graphical view]
PfamPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02245. HAD_IIID1. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBCP1_XENTR
AccessionPrimary (citable) accession number: Q28EX9
Secondary accession number(s): A4IHX3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families