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Q28EX9

- UBCP1_XENTR

UniProt

Q28EX9 - UBCP1_XENTR

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Protein
Ubiquitin-like domain-containing CTD phosphatase 1
Gene
ublcp1, TGas135j05.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:ublcp1
ORF Names:TGas135j05.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5892709. ublcp1.

Subcellular locationi

Nucleus By similarity
Note: Colocalizes with nuclear proteasomes By similarity.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1
PRO_0000242647Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28EX9.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000035725.

Structurei

3D structure databases

ProteinModelPortaliQ28EX9.
SMRiQ28EX9. Positions 3-79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8179Ubiquitin-like
Add
BLAST
Domaini133 – 294162FCP1 homology
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 294162Phosphatase By similarity
Add
BLAST

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG310886.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
KOiK17618.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28EX9-1 [UniParc]FASTAAdd to Basket

« Hide

MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY    50
KGKPAENDVK LGVLKLKPNT KIMMMGTREE SLEEMMAPPP ENDEVVNDFD 100
IEEEVVEVEN REENLAKISR RVKDYKIEIL NPPREGKKLL VLDVDYTLFD 150
HRSCAETGQE LMRPYLHEFL TSAYEDYDIV IWSATSMKWI EAKMKELGVS 200
TNSNYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG EFYNKNNTIM 250
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLSQY LKEIAQLDDL 300
SELNHKHWER YLVKKQGQ 318
Length:318
Mass (Da):36,854
Last modified:April 4, 2006 - v1
Checksum:i6544E1EF04FE4633
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR762286 mRNA. Translation: CAJ83586.1.
BC135735 mRNA. Translation: AAI35736.1.
RefSeqiNP_001016061.1. NM_001016061.2.
UniGeneiStr.13054.

Genome annotation databases

GeneIDi548815.
KEGGixtr:548815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR762286 mRNA. Translation: CAJ83586.1 .
BC135735 mRNA. Translation: AAI35736.1 .
RefSeqi NP_001016061.1. NM_001016061.2.
UniGenei Str.13054.

3D structure databases

ProteinModelPortali Q28EX9.
SMRi Q28EX9. Positions 3-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000035725.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 548815.
KEGGi xtr:548815.

Organism-specific databases

CTDi 134510.
Xenbasei XB-GENE-5892709. ublcp1.

Phylogenomic databases

eggNOGi NOG310886.
HOGENOMi HOG000231279.
HOVERGENi HBG080207.
KOi K17618.

Gene expression databases

Bgeei Q28EX9.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUBCP1_XENTR
AccessioniPrimary (citable) accession number: Q28EX9
Secondary accession number(s): A4IHX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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