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Q28EX9

- UBCP1_XENTR

UniProt

Q28EX9 - UBCP1_XENTR

Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

ublcp1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Nuclear proteasome inhibitor UBLCP1
    Gene namesi
    Name:ublcp1
    ORF Names:TGas135j05.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5892709. ublcp1.

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with nuclear proteasomes.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1PRO_0000242647Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ28EX9.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000035725.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28EX9.
    SMRiQ28EX9. Positions 3-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8179Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 294162FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 294162PhosphataseBy similarityAdd
    BLAST

    Domaini

    The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG310886.
    HOGENOMiHOG000231279.
    HOVERGENiHBG080207.
    KOiK17618.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28EX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY    50
    KGKPAENDVK LGVLKLKPNT KIMMMGTREE SLEEMMAPPP ENDEVVNDFD 100
    IEEEVVEVEN REENLAKISR RVKDYKIEIL NPPREGKKLL VLDVDYTLFD 150
    HRSCAETGQE LMRPYLHEFL TSAYEDYDIV IWSATSMKWI EAKMKELGVS 200
    TNSNYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG EFYNKNNTIM 250
    FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLSQY LKEIAQLDDL 300
    SELNHKHWER YLVKKQGQ 318
    Length:318
    Mass (Da):36,854
    Last modified:April 4, 2006 - v1
    Checksum:i6544E1EF04FE4633
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR762286 mRNA. Translation: CAJ83586.1.
    BC135735 mRNA. Translation: AAI35736.1.
    RefSeqiNP_001016061.1. NM_001016061.2.
    UniGeneiStr.13054.

    Genome annotation databases

    GeneIDi548815.
    KEGGixtr:548815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR762286 mRNA. Translation: CAJ83586.1 .
    BC135735 mRNA. Translation: AAI35736.1 .
    RefSeqi NP_001016061.1. NM_001016061.2.
    UniGenei Str.13054.

    3D structure databases

    ProteinModelPortali Q28EX9.
    SMRi Q28EX9. Positions 3-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000035725.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 548815.
    KEGGi xtr:548815.

    Organism-specific databases

    CTDi 134510.
    Xenbasei XB-GENE-5892709. ublcp1.

    Phylogenomic databases

    eggNOGi NOG310886.
    HOGENOMi HOG000231279.
    HOVERGENi HBG080207.
    KOi K17618.

    Gene expression databases

    Bgeei Q28EX9.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBCP1_XENTR
    AccessioniPrimary (citable) accession number: Q28EX9
    Secondary accession number(s): A4IHX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3