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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

ublcp1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:ublcp1
ORF Names:TGas135j05.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5892709. ublcp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426471 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST318

Proteomic databases

PaxDbiQ28EX9.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000035725.

Structurei

3D structure databases

ProteinModelPortaliQ28EX9.
SMRiQ28EX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
KOG1872. Eukaryota.
COG5190. LUCA.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ28EX9.
KOiK17618.
OrthoDBiEOG091G0CRH.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR004274. FCP1_dom.
IPR036412. HAD-like_sf.
IPR011943. HAD-SF_hydro_IIID.
IPR023214. HAD_sf.
IPR029071. Ubiquitin-like_domsf.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiView protein in PROSITE
PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28EX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY
60 70 80 90 100
KGKPAENDVK LGVLKLKPNT KIMMMGTREE SLEEMMAPPP ENDEVVNDFD
110 120 130 140 150
IEEEVVEVEN REENLAKISR RVKDYKIEIL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGQE LMRPYLHEFL TSAYEDYDIV IWSATSMKWI EAKMKELGVS
210 220 230 240 250
TNSNYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG EFYNKNNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLSQY LKEIAQLDDL
310
SELNHKHWER YLVKKQGQ
Length:318
Mass (Da):36,854
Last modified:April 4, 2006 - v1
Checksum:i6544E1EF04FE4633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762286 mRNA. Translation: CAJ83586.1.
BC135735 mRNA. Translation: AAI35736.1.
RefSeqiNP_001016061.1. NM_001016061.2.
UniGeneiStr.13054.

Genome annotation databases

GeneIDi548815.
KEGGixtr:548815.

Similar proteinsi

Entry informationi

Entry nameiUBCP1_XENTR
AccessioniPrimary (citable) accession number: Q28EX9
Secondary accession number(s): A4IHX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome