ID   DHSA_XENTR              Reviewed;         665 AA.
AC   Q28ED0; A4QNI5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;
DE            EC=1.3.5.1;
DE   AltName: Full=Flavoprotein subunit of complex II;
DE            Short=Fp;
DE   Flags: Precursor;
GN   Name=sdha; ORFNames=TNeu107a09.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase
CC       (SDH) that is involved in complex II of the mitochondrial electron
CC       transport chain and is responsible for transferring electrons from
CC       succinate to ubiquinone (coenzyme Q) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: the
CC       flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a
CC       cytochrome b560 composed of sdhc and sdhd (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC       membrane protein; Matrix side (By similarity).
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
CC       FRD/SDH subfamily.
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DR   EMBL; CR848322; CAJ83256.1; -; mRNA.
DR   EMBL; BC135730; AAI35731.1; -; mRNA.
DR   RefSeq; NP_001015989.1; -.
DR   UniGene; Str.9006; -.
DR   SMR; Q28ED0; 56-665.
DR   GeneID; 548743; -.
DR   KEGG; xtr:548743; -.
DR   Xenbase; XB-FEAT-956941; sdha.
DR   HOVERGEN; Q28ED0; -.
DR   BRENDA; 1.3.5.1; 279072.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR003953; FAD_bind2_N.
DR   InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase.
DR   InterPro; IPR003952; FRD_SDH_FAD_BS.
DR   InterPro; IPR004112; Fum_Rdtase/Succ_DH_flav_C.
DR   InterPro; IPR011281; Succ_DH_flav_su_fwd.
DR   InterPro; IPR014006; Succ_Dhase_frdA_Gneg.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   PRINTS; PR00368; FADPNR.
DR   TIGRFAMs; TIGR01816; sdhA_forward; 1.
DR   TIGRFAMs; TIGR01812; sdhA_frdA_Gneg; 1.
DR   PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Transit peptide;
KW   Transport; Tricarboxylic acid cycle.
FT   TRANSIT       1     43       Mitochondrion (Potential).
FT   CHAIN        44    665       Succinate dehydrogenase [ubiquinone]
FT                                flavoprotein subunit, mitochondrial.
FT                                /FTId=PRO_0000272307.
FT   NP_BIND      94    109       FAD (By similarity).
FT   ACT_SITE    343    343       Proton acceptor (By similarity).
FT   BINDING     299    299       Substrate (By similarity).
FT   BINDING     311    311       Substrate (By similarity).
FT   BINDING     410    410       Substrate (By similarity).
FT   BINDING     454    454       Substrate (By similarity).
FT   MOD_RES     102    102       Tele-8alpha-FAD histidine (By
FT                                similarity).
SQ   SEQUENCE   665 AA;  72706 MW;  6C0A8263F91E0649 CRC64;
     MAFLNVASSR LLSKTLQLGG RVQNCTATCT AATRNFHFSV YGRKDTSAKL SDSISTQYPV
     VDHDFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR SHTVAAQGGI NAALGNMEDD
     DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP ASVIELENYG MPFSRTEQGK IYQRAFGGQS
     LKFGKGGQAH RCCCVADRTG HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL
     CMEDGSIHRF RAKNTVIATG GYGRTFFSCT SAHTCTGDGT AMVTRAGLPC QDLEFVQFHP
     TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM TIEIREGRGC
     GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK EPIPVLPTVH YNMGGIPTNY
     KGQVITHVNG EDRVVPGLYA CGEAASASVH GANRLGANSL LDLVVFGRAC ALSIAESCKP
     GEPVPSIKEN AGEESVANLD KLRFTNGSTR TSELRINMQK TMQNHAAVFR TGSVLKEGCE
     KLSAINSTMD DIKTFDRGIV WNTDLVETLE LQNLMLCALQ TIYGAEARKE SRGAHAREDY
     KVRIDEYDYS KPIQGQQKKS FSEHWRKHTL SYVDGKGKVS LEYRPVIDTT LNEDCVSVPP
     AIRSY
//