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Q28ED0

- SDHA_XENTR

UniProt

Q28ED0 - SDHA_XENTR

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdha

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei278 – 2781FADBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei311 – 3111SubstrateBy similarity
    Active sitei343 – 3431Proton acceptorBy similarity
    Binding sitei410 – 4101SubstrateBy similarity
    Binding sitei443 – 4431FADBy similarity
    Binding sitei454 – 4541SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 766FADBy similarity
    Nucleotide bindingi94 – 10916FADBy similarityAdd
    BLAST
    Nucleotide bindingi459 – 4602FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. respiratory electron transport chain Source: UniProtKB
    2. succinate metabolic process Source: UniProtKB
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II
    Short name:
    Fp
    Gene namesi
    Name:sdha
    ORF Names:TNeu107a09.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-956942. sdha.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343MitochondrionSequence AnalysisAdd
    BLAST
    Chaini44 – 665622Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000272307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PRIDEiQ28ED0.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd. Interacts with sdhaf2/sdh5; interaction is required for FAD attachment By similarity.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000050574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28ED0.
    SMRiQ28ED0. Positions 54-665.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1053.
    HOVERGENiHBG001461.
    KOiK00234.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28ED0-1 [UniParc]FASTAAdd to Basket

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    MAFLNVASSR LLSKTLQLGG RVQNCTATCT AATRNFHFSV YGRKDTSAKL    50
    SDSISTQYPV VDHDFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR 100
    SHTVAAQGGI NAALGNMEDD DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP 150
    ASVIELENYG MPFSRTEQGK IYQRAFGGQS LKFGKGGQAH RCCCVADRTG 200
    HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL CMEDGSIHRF 250
    RAKNTVIATG GYGRTFFSCT SAHTCTGDGT AMVTRAGLPC QDLEFVQFHP 300
    TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM 350
    TIEIREGRGC GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK 400
    EPIPVLPTVH YNMGGIPTNY KGQVITHVNG EDRVVPGLYA CGEAASASVH 450
    GANRLGANSL LDLVVFGRAC ALSIAESCKP GEPVPSIKEN AGEESVANLD 500
    KLRFTNGSTR TSELRINMQK TMQNHAAVFR TGSVLKEGCE KLSAINSTMD 550
    DIKTFDRGIV WNTDLVETLE LQNLMLCALQ TIYGAEARKE SRGAHAREDY 600
    KVRIDEYDYS KPIQGQQKKS FSEHWRKHTL SYVDGKGKVS LEYRPVIDTT 650
    LNEDCVSVPP AIRSY 665
    Length:665
    Mass (Da):72,706
    Last modified:April 4, 2006 - v1
    Checksum:i6C0A8263F91E0649
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848322 mRNA. Translation: CAJ83256.1.
    BC135730 mRNA. Translation: AAI35731.1.
    RefSeqiNP_001015989.1. NM_001015989.2.
    UniGeneiStr.9006.

    Genome annotation databases

    GeneIDi548743.
    KEGGixtr:548743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848322 mRNA. Translation: CAJ83256.1 .
    BC135730 mRNA. Translation: AAI35731.1 .
    RefSeqi NP_001015989.1. NM_001015989.2.
    UniGenei Str.9006.

    3D structure databases

    ProteinModelPortali Q28ED0.
    SMRi Q28ED0. Positions 54-665.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000050574.

    Proteomic databases

    PRIDEi Q28ED0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 548743.
    KEGGi xtr:548743.

    Organism-specific databases

    CTDi 6389.
    Xenbasei XB-GENE-956942. sdha.

    Phylogenomic databases

    eggNOGi COG1053.
    HOVERGENi HBG001461.
    KOi K00234.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neurula.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiSDHA_XENTR
    AccessioniPrimary (citable) accession number: Q28ED0
    Secondary accession number(s): A4QNI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3