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Q28EB8

- Q28EB8_XENTR

UniProt

Q28EB8 - Q28EB8_XENTR

Protein

DNA ligase

Gene

lig4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:lig4Imported
    ORF Names:TNeu022j24.1-001Imported
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

    Organism-specific databases

    XenbaseiXB-GENE-964443. lig4.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000005699.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000007831.
    HOVERGENiHBG005516.
    KOiK10777.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 2 hits.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF00533. BRCT. 2 hits.
    PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 2 hits.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 2 hits.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28EB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATKASDSA AERTVASQVP FADLCCTLEK VQKCKNRTEK SHIFKQFVDS    50
    WRKFHEALHK SQPKTTDSFY PAMRLVVPQL ERERMAYGIK ETMLAKLYIK 100
    VLGLPKEGKD AIKLLNYRSP TSSHSDAGDF AAIAYFVLKS RCRKEGSLSI 150
    QEVNYHLDSI ANNNAAKKKE LIEKSLLHLI ANTTALEQKW LIRMIIKDMK 200
    LGFSQQTVFS IFHPDAAELH NVTTDLEKVC IQLHDPNVCL SDVSISMFSA 250
    FKPMLAAIAN IQNIEKQMNH QSFYIETKLD GERMQMHKDG DVYKYFSRNG 300
    FDYTQQFGAS PLEGSLTPYI HNAFSLNIQN CILDGEMMAY NPNTQTFMQK 350
    GNKFDIKRMV DDSELQTCYC VFDVLLLNDQ KLAHETLRKR YDILQEIFIP 400
    IPGRFHIVDK TEASTKKNVV DALNEAIDKR EEGIMVKDPM SIYKPDKRGE 450
    GWLKIKPEYV NGLMDELDLI IIGGYWGKGS RGGMMSHFLC GVAEASGPGE 500
    KPSVFHSICR VGSGYTMKEL FDLGLKLAPH WKTYRKRDPP SNILCGIEKP 550
    EAYIQPCNSV IVQIKAAEIV TSDMYKTGCT LRFPRIEKIR EDKEWYDCMT 600
    LDDLEQFRDK ASGKLASKHL HIDDEPHEKK RKTAPKLKKV IGIVSHLKAP 650
    DLSNVYQESS VFAEVEFCVM SGTDTHSKDD LANIIAKCGG IGVQNPGADT 700
    YCVIAGTENV RVKNIICSNK HDVVKAAWLL ECFESKTFVP WQPHHMIHMC 750
    PSTAEHFACE YDCYGDSYIT DTSEYQLREV FHRMSNIREK IPFEMMADLE 800
    ERYSWNNSSH SFFRHCTVYV DSFATINDPT TRINTSSLNL RALELRFYGA 850
    KLVNQLEEGI SHVVVGEDLS RLEQMKTMRR AIAKKFKIVS VSWVLDSVKM 900
    RVPQMENSYL L 911
    Length:911
    Mass (Da):103,871
    Last modified:April 4, 2006 - v1
    Checksum:i227B0C2705291ACC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC135341 mRNA. Translation: AAI35342.1.
    CR848338 mRNA. Translation: CAJ82384.1.
    RefSeqiNP_001016981.1. NM_001016981.2.
    UniGeneiStr.4239.

    Genome annotation databases

    GeneIDi549735.
    KEGGixtr:549735.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC135341 mRNA. Translation: AAI35342.1 .
    CR848338 mRNA. Translation: CAJ82384.1 .
    RefSeqi NP_001016981.1. NM_001016981.2.
    UniGenei Str.4239.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000005699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 549735.
    KEGGi xtr:549735.

    Organism-specific databases

    CTDi 3981.
    Xenbasei XB-GENE-964443. lig4.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000007831.
    HOVERGENi HBG005516.
    KOi K10777.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 2 hits.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF00533. BRCT. 2 hits.
    PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 2 hits.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 2 hits.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Whole embryoImported.

    Entry informationi

    Entry nameiQ28EB8_XENTR
    AccessioniPrimary (citable) accession number: Q28EB8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)