Q28EB8 (Q28EB8_XENTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

Name:	lig4 EMBL CAJ82384.1 Xenbase XB-GENE-964443
ORF Names:	TNeu022j24.1-001 EMBL CAJ82384.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) EMBL CAJ82384.1

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	911 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL CAJ82384.1
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q28EB8 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 227B0C2705291ACC	FASTA	911	103,871
	10 20 30 40 50 60 MSATKASDSA AERTVASQVP FADLCCTLEK VQKCKNRTEK SHIFKQFVDS WRKFHEALHK 70 80 90 100 110 120 SQPKTTDSFY PAMRLVVPQL ERERMAYGIK ETMLAKLYIK VLGLPKEGKD AIKLLNYRSP 130 140 150 160 170 180 TSSHSDAGDF AAIAYFVLKS RCRKEGSLSI QEVNYHLDSI ANNNAAKKKE LIEKSLLHLI 190 200 210 220 230 240 ANTTALEQKW LIRMIIKDMK LGFSQQTVFS IFHPDAAELH NVTTDLEKVC IQLHDPNVCL 250 260 270 280 290 300 SDVSISMFSA FKPMLAAIAN IQNIEKQMNH QSFYIETKLD GERMQMHKDG DVYKYFSRNG 310 320 330 340 350 360 FDYTQQFGAS PLEGSLTPYI HNAFSLNIQN CILDGEMMAY NPNTQTFMQK GNKFDIKRMV 370 380 390 400 410 420 DDSELQTCYC VFDVLLLNDQ KLAHETLRKR YDILQEIFIP IPGRFHIVDK TEASTKKNVV 430 440 450 460 470 480 DALNEAIDKR EEGIMVKDPM SIYKPDKRGE GWLKIKPEYV NGLMDELDLI IIGGYWGKGS 490 500 510 520 530 540 RGGMMSHFLC GVAEASGPGE KPSVFHSICR VGSGYTMKEL FDLGLKLAPH WKTYRKRDPP 550 560 570 580 590 600 SNILCGIEKP EAYIQPCNSV IVQIKAAEIV TSDMYKTGCT LRFPRIEKIR EDKEWYDCMT 610 620 630 640 650 660 LDDLEQFRDK ASGKLASKHL HIDDEPHEKK RKTAPKLKKV IGIVSHLKAP DLSNVYQESS 670 680 690 700 710 720 VFAEVEFCVM SGTDTHSKDD LANIIAKCGG IGVQNPGADT YCVIAGTENV RVKNIICSNK 730 740 750 760 770 780 HDVVKAAWLL ECFESKTFVP WQPHHMIHMC PSTAEHFACE YDCYGDSYIT DTSEYQLREV 790 800 810 820 830 840 FHRMSNIREK IPFEMMADLE ERYSWNNSSH SFFRHCTVYV DSFATINDPT TRINTSSLNL 850 860 870 880 890 900 RALELRFYGA KLVNQLEEGI SHVVVGEDLS RLEQMKTMRR AIAKKFKIVS VSWVLDSVKM 910 RVPQMENSYL L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K., Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V., McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J., Zorn A.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Whole embryo EMBL AAI35342.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC135341 mRNA. Translation: AAI35342.1. CR848338 mRNA. Translation: CAJ82384.1.
RefSeq	NP_001016981.1. NM_001016981.2.
UniGene	Str.4239.
3D structure databases
SMR	Q28EB8. Positions 659-762.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000005699.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	549735.
KEGG	xtr:549735.
Organism-specific databases
CTD	3981.
Xenbase	XB-GENE-964443. lig4.
Phylogenomic databases
eggNOG	COG1793.
HOGENOM	HOG000007831.
HOVERGEN	HBG005516.
KO	K10777.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit. 3.40.50.10190. 2 hits.
InterPro	IPR001357. BRCT_dom. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR021536. DNA_ligase_IV. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF00533. BRCT. 2 hits. PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. PF11411. DNA_ligase_IV. 1 hit. [Graphical view]
SMART	SM00292. BRCT. 2 hits. [Graphical view]
SUPFAM	SSF52113. BRCT. 2 hits. SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS50172. BRCT. 2 hits. PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q28EB8_XENTR

Accession

Primary (citable) accession number: Q28EB8

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)