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Protein

DNA ligase

Gene

lig4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:lig4Imported
ORF Names:TNeu022j24.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-964443. lig4.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005699.

Structurei

3D structure databases

ProteinModelPortaliQ28EB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000007831.
HOVERGENiHBG005516.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28EB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSATKASDSA AERTVASQVP FADLCCTLEK VQKCKNRTEK SHIFKQFVDS
60 70 80 90 100
WRKFHEALHK SQPKTTDSFY PAMRLVVPQL ERERMAYGIK ETMLAKLYIK
110 120 130 140 150
VLGLPKEGKD AIKLLNYRSP TSSHSDAGDF AAIAYFVLKS RCRKEGSLSI
160 170 180 190 200
QEVNYHLDSI ANNNAAKKKE LIEKSLLHLI ANTTALEQKW LIRMIIKDMK
210 220 230 240 250
LGFSQQTVFS IFHPDAAELH NVTTDLEKVC IQLHDPNVCL SDVSISMFSA
260 270 280 290 300
FKPMLAAIAN IQNIEKQMNH QSFYIETKLD GERMQMHKDG DVYKYFSRNG
310 320 330 340 350
FDYTQQFGAS PLEGSLTPYI HNAFSLNIQN CILDGEMMAY NPNTQTFMQK
360 370 380 390 400
GNKFDIKRMV DDSELQTCYC VFDVLLLNDQ KLAHETLRKR YDILQEIFIP
410 420 430 440 450
IPGRFHIVDK TEASTKKNVV DALNEAIDKR EEGIMVKDPM SIYKPDKRGE
460 470 480 490 500
GWLKIKPEYV NGLMDELDLI IIGGYWGKGS RGGMMSHFLC GVAEASGPGE
510 520 530 540 550
KPSVFHSICR VGSGYTMKEL FDLGLKLAPH WKTYRKRDPP SNILCGIEKP
560 570 580 590 600
EAYIQPCNSV IVQIKAAEIV TSDMYKTGCT LRFPRIEKIR EDKEWYDCMT
610 620 630 640 650
LDDLEQFRDK ASGKLASKHL HIDDEPHEKK RKTAPKLKKV IGIVSHLKAP
660 670 680 690 700
DLSNVYQESS VFAEVEFCVM SGTDTHSKDD LANIIAKCGG IGVQNPGADT
710 720 730 740 750
YCVIAGTENV RVKNIICSNK HDVVKAAWLL ECFESKTFVP WQPHHMIHMC
760 770 780 790 800
PSTAEHFACE YDCYGDSYIT DTSEYQLREV FHRMSNIREK IPFEMMADLE
810 820 830 840 850
ERYSWNNSSH SFFRHCTVYV DSFATINDPT TRINTSSLNL RALELRFYGA
860 870 880 890 900
KLVNQLEEGI SHVVVGEDLS RLEQMKTMRR AIAKKFKIVS VSWVLDSVKM
910
RVPQMENSYL L
Length:911
Mass (Da):103,871
Last modified:April 4, 2006 - v1
Checksum:i227B0C2705291ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135341 mRNA. Translation: AAI35342.1.
CR848338 mRNA. Translation: CAJ82384.1.
RefSeqiNP_001016981.1. NM_001016981.2.
UniGeneiStr.4239.

Genome annotation databases

GeneIDi549735.
KEGGixtr:549735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135341 mRNA. Translation: AAI35342.1.
CR848338 mRNA. Translation: CAJ82384.1.
RefSeqiNP_001016981.1. NM_001016981.2.
UniGeneiStr.4239.

3D structure databases

ProteinModelPortaliQ28EB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi549735.
KEGGixtr:549735.

Organism-specific databases

CTDi3981.
XenbaseiXB-GENE-964443. lig4.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000007831.
HOVERGENiHBG005516.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Whole embryoImported.

Entry informationi

Entry nameiQ28EB8_XENTR
AccessioniPrimary (citable) accession number: Q28EB8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 4, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.