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Protein

Protein MCM10 homolog

Gene

mcm10

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA replication

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-XTR-176187. Activation of ATR in response to replication stress.
R-XTR-68962. Activation of the pre-replicative complex.
R-XTR-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MCM10 homolog
Gene namesi
Name:mcm10
ORF Names:TEgg053h10.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1015391. mcm10.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002783241 – 845Protein MCM10 homologAdd BLAST845

Proteomic databases

PaxDbiQ28E45.
PRIDEiQ28E45.

Expressioni

Gene expression databases

BgeeiENSXETG00000009113.

Interactioni

Subunit structurei

Self-associates.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019989.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 145N-terminal domainBy similarityAdd BLAST145
Regioni217 – 367OB-fold domainBy similarityAdd BLAST151
Regioni368 – 393Zinc finger-like 1Add BLAST26
Regioni754 – 773Zinc finger-like 2By similarityAdd BLAST20
Regioni787 – 807Zinc finger-like 3By similarityAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 131Sequence analysisAdd BLAST39

Domaini

Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.By similarity
The N-terminal domain mediates homodimerization.By similarity

Sequence similaritiesi

Belongs to the MCM10 family.Curated

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3056. Eukaryota.
ENOG41100ZT. LUCA.
GeneTreeiENSGT00390000007134.
HOGENOMiHOG000082481.
HOVERGENiHBG055312.
InParanoidiQ28E45.
KOiK10736.
OMAiKHCSNCG.
OrthoDBiEOG091G053R.
TreeFamiTF313330.

Family and domain databases

InterProiIPR015411. Rep_factor_Mcm10_C.
IPR015408. Znf_Mcm10/DnaG.
[Graphical view]
PfamiPF09332. Mcm10. 1 hit.
PF09329. zf-primase. 1 hit.
[Graphical view]
SMARTiSM01280. Mcm10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28E45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVDADLEL LTSLLEENEA AESNSVESHE ASSELDEYDE LFDGDEDGSY
60 70 80 90 100
HESDNGTEEQ TVDGVEENFD TLFGDIDDIN EEETVAPDTK KQSSVCQDKS
110 120 130 140 150
KHELEDELRK MQEQMRKLQK QLQQTALAKT SSPGNPMKSP DNKLLLSGKT
160 170 180 190 200
FQSGPLLERS LTVPKANLQD TPKRKQNLQD KSPLQKQMTS FLSPPDKSST
210 220 230 240 250
RPVSSTATQP VLNPVRSPVG QQYPVEKFSG LRLRKPRVSS SEMERKMNGR
260 270 280 290 300
KLIRLAQLQN KIVTEKLEDE DWVTFGVIVK KITPQSSNNG KTFSIWRLND
310 320 330 340 350
LKNLDKYVSL FLFGDVHKEH WKTDQGTVIG LLNANPMKPK EGTDEVCLSV
360 370 380 390 400
DNPQKVLLMG DAVDLGTCKA RKKNGDPCTQ MVNLNDCEYC QYHVQAQYKK
410 420 430 440 450
VSSKRADLQS SYSGHVPKKM ARGGNGLRER LCQDGFHYGG VSSMAYATTL
460 470 480 490 500
ASTTAPKKTV QSTLSNMVVR GAEAIALEAR QQIAAARKNM VQSDEFKELM
510 520 530 540 550
TLPTPGALNL KKHFSGVPTQ ANEKGGQPFQ SISASALLKQ QKQQMLGARK
560 570 580 590 600
KRAEEIQKRF LESTEKSEKS STLVSSERSV FQSPKQGAEF PNAQKMATPK
610 620 630 640 650
LGRGFAEGED VLFFDISPPA AKSNTSAQAT KLAAIQKLQA KGQTLTKADP
660 670 680 690 700
NSIKRKRSSS AEELVAQRVA SHAPASTKSP DENEPAMKKH REQLAYLESK
710 720 730 740 750
EFQKILNAKS KHTGILKEAE AEIQERYFDP LVKKEQLEEK MRSIREQECR
760 770 780 790 800
VVTCKTCKYT HFKPKETCVS ENHDFHWHNG VKRFFKCACG NRTISLDRLP
810 820 830 840
KKHCSTCGLF KWERDGMLKE KTGPKIAGET LLPRGEEHGK FLNSH
Length:845
Mass (Da):94,491
Last modified:April 4, 2006 - v1
Checksum:iD264D9DD947C2D00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848457 mRNA. Translation: CAJ82204.1.
RefSeqiNP_001016909.1. NM_001016909.2.
XP_012814512.1. XM_012959058.2.
UniGeneiStr.1798.

Genome annotation databases

EnsembliENSXETT00000019989; ENSXETP00000019989; ENSXETG00000009113.
GeneIDi549663.
KEGGixtr:549663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848457 mRNA. Translation: CAJ82204.1.
RefSeqiNP_001016909.1. NM_001016909.2.
XP_012814512.1. XM_012959058.2.
UniGeneiStr.1798.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019989.

Proteomic databases

PaxDbiQ28E45.
PRIDEiQ28E45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000019989; ENSXETP00000019989; ENSXETG00000009113.
GeneIDi549663.
KEGGixtr:549663.

Organism-specific databases

CTDi55388.
XenbaseiXB-GENE-1015391. mcm10.

Phylogenomic databases

eggNOGiKOG3056. Eukaryota.
ENOG41100ZT. LUCA.
GeneTreeiENSGT00390000007134.
HOGENOMiHOG000082481.
HOVERGENiHBG055312.
InParanoidiQ28E45.
KOiK10736.
OMAiKHCSNCG.
OrthoDBiEOG091G053R.
TreeFamiTF313330.

Enzyme and pathway databases

ReactomeiR-XTR-176187. Activation of ATR in response to replication stress.
R-XTR-68962. Activation of the pre-replicative complex.
R-XTR-69300. Removal of licensing factors from origins.

Gene expression databases

BgeeiENSXETG00000009113.

Family and domain databases

InterProiIPR015411. Rep_factor_Mcm10_C.
IPR015408. Znf_Mcm10/DnaG.
[Graphical view]
PfamiPF09332. Mcm10. 1 hit.
PF09329. zf-primase. 1 hit.
[Graphical view]
SMARTiSM01280. Mcm10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCM10_XENTR
AccessioniPrimary (citable) accession number: Q28E45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.