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Protein

Molybdate-anion transporter

Gene

mfsd5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.40.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate-anion transporter
Alternative name(s):
Major facilitator superfamily domain-containing protein 5
Molybdate transporter 2 homolog
Gene namesi
Name:mfsd5
ORF Names:TEgg028j23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-967131. mfsd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Molybdate-anion transporterPRO_0000273407Add
BLAST

Proteomic databases

PaxDbiQ28E13.

Expressioni

Gene expression databases

BgeeiENSXETG00000012669.
ExpressionAtlasiQ28E13. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027721.

Structurei

3D structure databases

ProteinModelPortaliQ28E13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4332. Eukaryota.
ENOG410XSP5. LUCA.
GeneTreeiENSGT00390000012629.
HOGENOMiHOG000239662.
HOVERGENiHBG081970.
InParanoidiQ28E13.
OMAiLEFSACR.
OrthoDBiEOG091G0CEM.
TreeFamiTF328562.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR008509. MOT2/MFSD5.
[Graphical view]
PfamiPF05631. MFS_5. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28E13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTAYFVLV GLIALWAVLE FSACHSKPST SSNAVGNPAF RQFQYDFYRT
60 70 80 90 100
YFPALAADWL QGPYLYKLYQ HYHFLEGQIA IIYVCGFGAS VFAGLVSAPL
110 120 130 140 150
TSRLGRRKSC ILFCLLLSAS YLCKLSQEYF VLITGRVLGG FSSSLLFSSF
160 170 180 190 200
EAWYTHEHAE QHDFPAEWLP HTFTRAAAWN GGIAIAAGVI ANACAEWLGL
210 220 230 240 250
GPASPSVLAV PLLVLSVALV IREWDENYGQ TSSFRRVCGD GLRCLLRDRR
260 270 280 290 300
VLLLGTIQAL FESVVYIFIF LWTPVLDPHN TPLGIAFSSF MAASAAGSSL
310 320 330 340 350
YRLATSKKYH LQPMHVLCLS ILMVFFSLFM LTFSTAPGQE HPTESLLAFL
360 370 380 390 400
LIELACGLYF PAMGFLRCRL IPEKEQIGVL NWFRVPLNLL AGLGLLVLHD
410 420 430 440 450
SDYQSGTRNM FSLCAITMLL ALLCVVSLFT MVRNDSELRL PTSETEPNGT

EQ
Length:452
Mass (Da):50,195
Last modified:April 4, 2006 - v1
Checksum:i15492FDDE06EEB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848498 mRNA. Translation: CAJ82274.1.
RefSeqiNP_001015939.1. NM_001015939.2.
UniGeneiStr.15101.

Genome annotation databases

EnsembliENSXETT00000027721; ENSXETP00000027721; ENSXETG00000012669.
GeneIDi548693.
KEGGixtr:548693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848498 mRNA. Translation: CAJ82274.1.
RefSeqiNP_001015939.1. NM_001015939.2.
UniGeneiStr.15101.

3D structure databases

ProteinModelPortaliQ28E13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027721.

Protein family/group databases

TCDBi2.A.1.40.3. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ28E13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000027721; ENSXETP00000027721; ENSXETG00000012669.
GeneIDi548693.
KEGGixtr:548693.

Organism-specific databases

CTDi84975.
XenbaseiXB-GENE-967131. mfsd5.

Phylogenomic databases

eggNOGiKOG4332. Eukaryota.
ENOG410XSP5. LUCA.
GeneTreeiENSGT00390000012629.
HOGENOMiHOG000239662.
HOVERGENiHBG081970.
InParanoidiQ28E13.
OMAiLEFSACR.
OrthoDBiEOG091G0CEM.
TreeFamiTF328562.

Gene expression databases

BgeeiENSXETG00000012669.
ExpressionAtlasiQ28E13. baseline.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR008509. MOT2/MFSD5.
[Graphical view]
PfamiPF05631. MFS_5. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMFSD5_XENTR
AccessioniPrimary (citable) accession number: Q28E13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: April 4, 2006
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.