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Protein

Molybdate-anion transporter

Gene

mfsd5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.By similarity

GO - Molecular functioni

Keywordsi

Biological processIon transport, Transport

Protein family/group databases

TCDBi2.A.1.40.3 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate-anion transporter
Alternative name(s):
Major facilitator superfamily domain-containing protein 5
Molybdate transporter 2 homolog
Gene namesi
Name:mfsd5
ORF Names:TEgg028j23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-967131 mfsd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734071 – 452Molybdate-anion transporterAdd BLAST452

Proteomic databases

PaxDbiQ28E13

Expressioni

Gene expression databases

BgeeiENSXETG00000012669
ExpressionAtlasiQ28E13 baseline

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027721

Structurei

3D structure databases

ProteinModelPortaliQ28E13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4332 Eukaryota
ENOG410XSP5 LUCA
GeneTreeiENSGT00390000012629
HOGENOMiHOG000239662
HOVERGENiHBG081970
InParanoidiQ28E13
OMAiVIANACA
OrthoDBiEOG091G0CEM
TreeFamiTF328562

Family and domain databases

InterProiView protein in InterPro
IPR036259 MFS_trans_sf
IPR008509 MOT2/MFSD5
PANTHERiPTHR23516 PTHR23516, 1 hit
PfamiView protein in Pfam
PF05631 MFS_5, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequencei

Sequence statusi: Complete.

Q28E13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTAYFVLV GLIALWAVLE FSACHSKPST SSNAVGNPAF RQFQYDFYRT
60 70 80 90 100
YFPALAADWL QGPYLYKLYQ HYHFLEGQIA IIYVCGFGAS VFAGLVSAPL
110 120 130 140 150
TSRLGRRKSC ILFCLLLSAS YLCKLSQEYF VLITGRVLGG FSSSLLFSSF
160 170 180 190 200
EAWYTHEHAE QHDFPAEWLP HTFTRAAAWN GGIAIAAGVI ANACAEWLGL
210 220 230 240 250
GPASPSVLAV PLLVLSVALV IREWDENYGQ TSSFRRVCGD GLRCLLRDRR
260 270 280 290 300
VLLLGTIQAL FESVVYIFIF LWTPVLDPHN TPLGIAFSSF MAASAAGSSL
310 320 330 340 350
YRLATSKKYH LQPMHVLCLS ILMVFFSLFM LTFSTAPGQE HPTESLLAFL
360 370 380 390 400
LIELACGLYF PAMGFLRCRL IPEKEQIGVL NWFRVPLNLL AGLGLLVLHD
410 420 430 440 450
SDYQSGTRNM FSLCAITMLL ALLCVVSLFT MVRNDSELRL PTSETEPNGT

EQ
Length:452
Mass (Da):50,195
Last modified:April 4, 2006 - v1
Checksum:i15492FDDE06EEB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848498 mRNA Translation: CAJ82274.1
RefSeqiNP_001015939.1, NM_001015939.2
UniGeneiStr.15101

Genome annotation databases

EnsembliENSXETT00000027721; ENSXETP00000027721; ENSXETG00000012669
GeneIDi548693
KEGGixtr:548693

Similar proteinsi

Entry informationi

Entry nameiMFSD5_XENTR
AccessioniPrimary (citable) accession number: Q28E13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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