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Q28DV3

- HDAC3_XENTR

UniProt

Q28DV3 - HDAC3_XENTR

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Protein

Histone deacetylase 3

Gene

hdac3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_202293. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_202908. p75NTR negatively regulates cell cycle via SC1.
REACT_207802. Transcriptional regulation of white adipocyte differentiation.
REACT_209742. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_214055. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_214942. RORA activates circadian gene expression.
REACT_218703. Circadian Clock.
REACT_221472. PPARA activates gene expression.
REACT_222096. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_225393. REV-ERBA represses gene expression.
REACT_226491. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 3 (EC:3.5.1.98)
Short name:
HD3
Gene namesi
Name:hdac3
ORF Names:TEgg067n06.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-481106. hdac3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histone deacetylase 3PRO_0000281032Add
BLAST

Proteomic databases

PRIDEiQ28DV3.

Expressioni

Gene expression databases

BgeeiQ28DV3.
ExpressionAtlasiQ28DV3. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005840.

Structurei

3D structure databases

ProteinModelPortaliQ28DV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 316314Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
InParanoidiQ28DV3.
KOiK11404.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q28DV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTVAYFYD PDVGNFHYGT GHPMKPHRLS LTHSLVLHYG LYKKMIVFKP
60 70 80 90 100
YQASQHDMCR FHSEDYIDFL QRVSPNNMQG FTKSLNAFNV GDDCPVFPGL
110 120 130 140 150
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
160 170 180 190 200
VIGILELLKY HPRVLYVDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
210 220 230 240 250
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRHLFQPVI KQVIDFYQPT
260 270 280 290 300
CIVLQCGADS LGCDRLGCFN LSIRGHGECV QYVKSFNIPL LVLGGGGYTV
310 320 330 340 350
RNVARCWTYE TSLLVDETIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN
360 370 380 390 400
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PSDILSYERT DEPDPEERGS
410 420
EDNYSRPEAS NEFYDGDHDN DKESDVEI
Length:428
Mass (Da):48,998
Last modified:April 4, 2006 - v1
Checksum:i445BED2F445D1AC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848582 mRNA. Translation: CAJ81493.1.
RefSeqiNP_001016883.1. NM_001016883.2.
UniGeneiStr.20485.

Genome annotation databases

GeneIDi549637.
KEGGixtr:549637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848582 mRNA. Translation: CAJ81493.1 .
RefSeqi NP_001016883.1. NM_001016883.2.
UniGenei Str.20485.

3D structure databases

ProteinModelPortali Q28DV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000005840.

Proteomic databases

PRIDEi Q28DV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 549637.
KEGGi xtr:549637.

Organism-specific databases

CTDi 8841.
Xenbasei XB-GENE-481106. hdac3.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000225180.
HOVERGENi HBG057112.
InParanoidi Q28DV3.
KOi K11404.

Enzyme and pathway databases

Reactomei REACT_202293. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_202908. p75NTR negatively regulates cell cycle via SC1.
REACT_207802. Transcriptional regulation of white adipocyte differentiation.
REACT_209742. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_214055. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_214942. RORA activates circadian gene expression.
REACT_218703. Circadian Clock.
REACT_221472. PPARA activates gene expression.
REACT_222096. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_225393. REV-ERBA represses gene expression.
REACT_226491. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Gene expression databases

Bgeei Q28DV3.
ExpressionAtlasi Q28DV3. baseline.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiHDAC3_XENTR
AccessioniPrimary (citable) accession number: Q28DV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3