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Q28DV3

- HDAC3_XENTR

UniProt

Q28DV3 - HDAC3_XENTR

Protein

Histone deacetylase 3

Gene

hdac3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351By similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_202293. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_202908. p75NTR negatively regulates cell cycle via SC1.
    REACT_207802. Transcriptional regulation of white adipocyte differentiation.
    REACT_209742. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_214055. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_214942. RORA activates circadian gene expression.
    REACT_218703. Circadian Clock.
    REACT_221472. PPARA activates gene expression.
    REACT_222096. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_225393. REV-ERBA represses gene expression.
    REACT_226491. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 3 (EC:3.5.1.98)
    Short name:
    HD3
    Gene namesi
    Name:hdac3
    ORF Names:TEgg067n06.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-481106. hdac3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Histone deacetylase 3PRO_0000281032Add
    BLAST

    Proteomic databases

    PRIDEiQ28DV3.

    Expressioni

    Gene expression databases

    BgeeiQ28DV3.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000005840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28DV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni3 – 316314Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225180.
    HOVERGENiHBG057112.
    KOiK11404.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    Q28DV3-1 [UniParc]FASTAAdd to Basket

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    MAKTVAYFYD PDVGNFHYGT GHPMKPHRLS LTHSLVLHYG LYKKMIVFKP    50
    YQASQHDMCR FHSEDYIDFL QRVSPNNMQG FTKSLNAFNV GDDCPVFPGL 100
    FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI 150
    VIGILELLKY HPRVLYVDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF 200
    PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRHLFQPVI KQVIDFYQPT 250
    CIVLQCGADS LGCDRLGCFN LSIRGHGECV QYVKSFNIPL LVLGGGGYTV 300
    RNVARCWTYE TSLLVDETIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN 350
    SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PSDILSYERT DEPDPEERGS 400
    EDNYSRPEAS NEFYDGDHDN DKESDVEI 428
    Length:428
    Mass (Da):48,998
    Last modified:April 4, 2006 - v1
    Checksum:i445BED2F445D1AC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848582 mRNA. Translation: CAJ81493.1.
    RefSeqiNP_001016883.1. NM_001016883.2.
    UniGeneiStr.20485.

    Genome annotation databases

    GeneIDi549637.
    KEGGixtr:549637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848582 mRNA. Translation: CAJ81493.1 .
    RefSeqi NP_001016883.1. NM_001016883.2.
    UniGenei Str.20485.

    3D structure databases

    ProteinModelPortali Q28DV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000005840.

    Proteomic databases

    PRIDEi Q28DV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 549637.
    KEGGi xtr:549637.

    Organism-specific databases

    CTDi 8841.
    Xenbasei XB-GENE-481106. hdac3.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225180.
    HOVERGENi HBG057112.
    KOi K11404.

    Enzyme and pathway databases

    Reactomei REACT_202293. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_202908. p75NTR negatively regulates cell cycle via SC1.
    REACT_207802. Transcriptional regulation of white adipocyte differentiation.
    REACT_209742. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_214055. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_214942. RORA activates circadian gene expression.
    REACT_218703. Circadian Clock.
    REACT_221472. PPARA activates gene expression.
    REACT_222096. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_225393. REV-ERBA represses gene expression.
    REACT_226491. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Gene expression databases

    Bgeei Q28DV3.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.

    Entry informationi

    Entry nameiHDAC3_XENTR
    AccessioniPrimary (citable) accession number: Q28DV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3