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Q28DT3 (PLD6_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mitochondrial cardiolipin hydrolase
EC=3.1.4.-
Alternative name(s):
Choline phosphatase 6
Mitochondrial phospholipase
Short name=MitoPLD
Phosphatidylcholine-hydrolyzing phospholipase D6
Phospholipase D6
Short name=PLD 6
Gene names
Name:pld6
ORF Names:TGas067k05.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Domain

In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site By similarity.

Sequence similarities

Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.

Contains 1 PLD phosphodiesterase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Mitochondrial cardiolipin hydrolase
PRO_0000325914

Regions

Topological domain1 – 66Mitochondrial intermembrane Potential
Transmembrane7 – 2418Helical; Potential
Topological domain25 – 210186Cytoplasmic Potential
Domain138 – 16528PLD phosphodiesterase

Sites

Active site1431 Potential
Active site1451 Potential
Active site1501 Potential

Experimental info

Sequence conflict101V → A in CAJ83564. Ref.1
Sequence conflict1021S → T in CAJ83564. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q28DT3 [UniParc].

Last modified May 3, 2011. Version 2.
Checksum: 62DF4B0213C3C6C7

FASTA21023,897
        10         20         30         40         50         60 
MLLWGRWKVV AGLAGLALSL ELLLRYMRRR KPIREVLFFP APVTCIEPVL YPMKQCSCPL 

        70         80         90        100        110        120 
PHTDSAFSRL LLLLLRAQRS LELCVFTFSC PSLARAVLLL HSRGVRVRVI TDNDYMAASG 

       130        140        150        160        170        180 
SQIGPLRSAG VAVRHDQSSG YMHHKFAVVD GTVVLTGSLN WTVQATQTNR ENILITDDRV 

       190        200        210 
IVKAYQQEFE RLWQEYDPAS YDFFPEKENK

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848611 mRNA. Translation: CAJ83564.1.
BC161584 mRNA. Translation: AAI61584.1.
RefSeqNP_001016875.2. NM_001016875.3.
UniGeneStr.27332.

3D structure databases

ProteinModelPortalQ28DT3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ28DT3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000012653; ENSXETP00000012653; ENSXETG00000005747.
GeneID549629.
KEGGxtr:549629.

Organism-specific databases

CTD201164.
XenbaseXB-GENE-5729937. pld6.

Phylogenomic databases

GeneTreeENSGT00390000004368.
HOVERGENHBG108267.
OrthoDBEOG402WTD.

Gene expression databases

BgeeQ28DT3.

Family and domain databases

InterProIPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
SMARTSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLD6_XENTR
AccessionPrimary (citable) accession number: Q28DT3
Secondary accession number(s): B1WB21
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 3, 2011
Last modified: November 16, 2011
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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