Reviewed, UniProtKB/Swiss-Prot Q28DT3 (PLD6_XENTR)

Names and origin

Protein names

Recommended name:
    Phospholipase D6
      Short name=PLD 6
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase 6
    Phosphatidylcholine-hydrolyzing phospholipase D6

Gene names

Name:	pld6
ORF Names:	TGas067k05.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the Phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Phospholipase D6		PRO_0000325914
Regions
	Transmembrane	7 – 24	18	Potential
	Domain	138 – 165	28	PLD phosphodiesterase
Sites
	Active site	143	1	Potential
	Active site	145	1	Potential
	Active site	150	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28DT3-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 1FA19F73A80D7063	FASTA	210	23,883
	10 20 30 40 50 60 MLLWGRWKVA AGLAGLALSL ELLLRYMRRR KPIREVLFFP APVTCIEPVL YPMKQCSCPL 70 80 90 100 110 120 PHTDSAFSRL LLLLLRAQRS LELCVFTFSC PSLARAVLLL HTRGVRVRVI TDNDYMAASG 130 140 150 160 170 180 SQIGPLRSAG VAVRHDQSSG YMHHKFAVVD GTVVLTGSLN WTVQATQTNR ENILITDDRV 190 200 210 IVKAYQQEFE RLWQEYDPAS YDFFPEKENK

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastrula.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848611 mRNA. Translation: CAJ83564.1.
RefSeq	NP_001016875.1.
UniGene	Str.27332
3D structure databases
SMR	Q28DT3. Positions 65-198.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28DT3.
Genome annotation databases
GeneID	549629.
KEGG	xtr:549629.
Organism-specific databases
CTD	549629.
Xenbase	XB-FEAT-5729936. pld6.
Phylogenomic databases
HOVERGEN	Q28DT3.
OMA	FPSQVTC.
OrthoDB	EOG9MSGHX.
Enzyme and pathway databases
BRENDA	3.1.4.4. 279072.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
SMART	SM00155. PLDc. 1 hit. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD6_XENTR

Accession

Primary (citable) accession number: Q28DT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	April 4, 2006
Last modified:	January 19, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project