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Q28DK1

- CISY_XENTR

UniProt

Q28DK1 - CISY_XENTR

Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031PROSITE-ProRule annotation
    Active sitei349 – 3491PROSITE-ProRule annotation
    Active sitei404 – 4041PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB
    2. cellular carbohydrate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, mitochondrial (EC:2.3.3.1)
    Alternative name(s):
    Citrate (Si)-synthase
    Gene namesi
    Name:cs
    ORF Names:TNeu053d23.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-943160. cs.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253910Add
    BLAST

    Proteomic databases

    PaxDbiQ28DK1.
    PRIDEiQ28DK1.

    Expressioni

    Gene expression databases

    BgeeiQ28DK1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000020990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28DK1.
    SMRiQ28DK1. Positions 30-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    GeneTreeiENSGT00390000006813.
    HOGENOMiHOG000130831.
    HOVERGENiHBG005336.
    KOiK01647.
    OMAiMQKDSKF.
    OrthoDBiEOG73BVCB.
    TreeFamiTF300398.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28DK1-1 [UniParc]FASTAAdd to Basket

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    MSLITAGRLC ARILGAKNSP CALIAARQAS SSANLKDVLS DLIPKEQTRI    50
    KNFRQQYGKN VIGQITVDMM YGGMRGMKGL VYETSVLDPD EGIRFRGYSI 100
    PECQKLLPKA PGGEEPLPEG LFWLLVTGEA PSQEQVNWIS KEWAKRAALP 150
    SHVVTMLDNF PTNLHPMSQL SAAITALNSE SNFARGYAEG VNKTKYWELI 200
    YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH NFTNMLGYTD 250
    PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG 300
    PLHGLANQEV LVWLTSLQKD LGGEVSDEKL RDYIWNTLNS GRVVPGYGHA 350
    VLRKTDPRYT CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW 400
    PNVDAHSGVL LQYYGMKEMN YYTVLFGVSR ALGVLAQLIW SRALGFPLER 450
    PKSMSTDGLM QLVGSKSG 468
    Length:468
    Mass (Da):51,834
    Last modified:April 4, 2006 - v1
    Checksum:i228AAC80C8D20813
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855469 mRNA. Translation: CAJ83375.1.
    BC127380 mRNA. Translation: AAI27381.1.
    RefSeqiNP_001017313.1. NM_001017313.3.
    UniGeneiStr.1513.

    Genome annotation databases

    EnsembliENSXETT00000020990; ENSXETP00000020990; ENSXETG00000009506.
    GeneIDi550067.
    KEGGixtr:550067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855469 mRNA. Translation: CAJ83375.1 .
    BC127380 mRNA. Translation: AAI27381.1 .
    RefSeqi NP_001017313.1. NM_001017313.3.
    UniGenei Str.1513.

    3D structure databases

    ProteinModelPortali Q28DK1.
    SMRi Q28DK1. Positions 30-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000020990.

    Proteomic databases

    PaxDbi Q28DK1.
    PRIDEi Q28DK1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000020990 ; ENSXETP00000020990 ; ENSXETG00000009506 .
    GeneIDi 550067.
    KEGGi xtr:550067.

    Organism-specific databases

    CTDi 1431.
    Xenbasei XB-GENE-943160. cs.

    Phylogenomic databases

    eggNOGi COG0372.
    GeneTreei ENSGT00390000006813.
    HOGENOMi HOG000130831.
    HOVERGENi HBG005336.
    KOi K01647.
    OMAi MQKDSKF.
    OrthoDBi EOG73BVCB.
    TreeFami TF300398.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Gene expression databases

    Bgeei Q28DK1.

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neurula.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: N6.
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiCISY_XENTR
    AccessioniPrimary (citable) accession number: Q28DK1
    Secondary accession number(s): A0JPE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3