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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase, mitochondrial (cs)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei303PROSITE-ProRule annotation1
Active sitei349PROSITE-ProRule annotation1
Active sitei404PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiR-XTR-71403. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
ORF Names:TNeu053d23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-943160. cs.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000025391031 – 468Citrate synthase, mitochondrialAdd BLAST438

Proteomic databases

PaxDbiQ28DK1.
PRIDEiQ28DK1.

Expressioni

Gene expression databases

BgeeiENSXETG00000009506.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020990.

Structurei

3D structure databases

ProteinModelPortaliQ28DK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617. Eukaryota.
COG0372. LUCA.
GeneTreeiENSGT00390000006813.
HOGENOMiHOG000130831.
HOVERGENiHBG005336.
InParanoidiQ28DK1.
KOiK01647.
OMAiDWSANFS.
OrthoDBiEOG091G068F.
TreeFamiTF300398.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28DK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLITAGRLC ARILGAKNSP CALIAARQAS SSANLKDVLS DLIPKEQTRI
60 70 80 90 100
KNFRQQYGKN VIGQITVDMM YGGMRGMKGL VYETSVLDPD EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA PGGEEPLPEG LFWLLVTGEA PSQEQVNWIS KEWAKRAALP
160 170 180 190 200
SHVVTMLDNF PTNLHPMSQL SAAITALNSE SNFARGYAEG VNKTKYWELI
210 220 230 240 250
YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH NFTNMLGYTD
260 270 280 290 300
PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLTSLQKD LGGEVSDEKL RDYIWNTLNS GRVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGMKEMN YYTVLFGVSR ALGVLAQLIW SRALGFPLER
460
PKSMSTDGLM QLVGSKSG
Length:468
Mass (Da):51,834
Last modified:April 4, 2006 - v1
Checksum:i228AAC80C8D20813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855469 mRNA. Translation: CAJ83375.1.
BC127380 mRNA. Translation: AAI27381.1.
RefSeqiNP_001017313.1. NM_001017313.3.
UniGeneiStr.1513.

Genome annotation databases

EnsembliENSXETT00000020990; ENSXETP00000020990; ENSXETG00000009506.
GeneIDi550067.
KEGGixtr:550067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855469 mRNA. Translation: CAJ83375.1.
BC127380 mRNA. Translation: AAI27381.1.
RefSeqiNP_001017313.1. NM_001017313.3.
UniGeneiStr.1513.

3D structure databases

ProteinModelPortaliQ28DK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020990.

Proteomic databases

PaxDbiQ28DK1.
PRIDEiQ28DK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000020990; ENSXETP00000020990; ENSXETG00000009506.
GeneIDi550067.
KEGGixtr:550067.

Organism-specific databases

CTDi1431.
XenbaseiXB-GENE-943160. cs.

Phylogenomic databases

eggNOGiKOG2617. Eukaryota.
COG0372. LUCA.
GeneTreeiENSGT00390000006813.
HOGENOMiHOG000130831.
HOVERGENiHBG005336.
InParanoidiQ28DK1.
KOiK01647.
OMAiDWSANFS.
OrthoDBiEOG091G068F.
TreeFamiTF300398.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.
ReactomeiR-XTR-71403. Citric acid cycle (TCA cycle).

Gene expression databases

BgeeiENSXETG00000009506.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCISY_XENTR
AccessioniPrimary (citable) accession number: Q28DK1
Secondary accession number(s): A0JPE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 4, 2006
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.