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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiREACT_290218. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
ORF Names:TNeu053d23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-943160. cs.

Subcellular locationi

  1. Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253910Add
BLAST

Proteomic databases

PaxDbiQ28DK1.
PRIDEiQ28DK1.

Expressioni

Gene expression databases

BgeeiQ28DK1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020990.

Structurei

3D structure databases

ProteinModelPortaliQ28DK1.
SMRiQ28DK1. Positions 30-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00390000006813.
HOGENOMiHOG000130831.
HOVERGENiHBG005336.
InParanoidiQ28DK1.
KOiK01647.
OMAiAYEQGDI.
OrthoDBiEOG73BVCB.
TreeFamiTF300398.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28DK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLITAGRLC ARILGAKNSP CALIAARQAS SSANLKDVLS DLIPKEQTRI
60 70 80 90 100
KNFRQQYGKN VIGQITVDMM YGGMRGMKGL VYETSVLDPD EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA PGGEEPLPEG LFWLLVTGEA PSQEQVNWIS KEWAKRAALP
160 170 180 190 200
SHVVTMLDNF PTNLHPMSQL SAAITALNSE SNFARGYAEG VNKTKYWELI
210 220 230 240 250
YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH NFTNMLGYTD
260 270 280 290 300
PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLTSLQKD LGGEVSDEKL RDYIWNTLNS GRVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGMKEMN YYTVLFGVSR ALGVLAQLIW SRALGFPLER
460
PKSMSTDGLM QLVGSKSG
Length:468
Mass (Da):51,834
Last modified:April 4, 2006 - v1
Checksum:i228AAC80C8D20813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855469 mRNA. Translation: CAJ83375.1.
BC127380 mRNA. Translation: AAI27381.1.
RefSeqiNP_001017313.1. NM_001017313.3.
UniGeneiStr.1513.

Genome annotation databases

EnsembliENSXETT00000020990; ENSXETP00000020990; ENSXETG00000009506.
GeneIDi550067.
KEGGixtr:550067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855469 mRNA. Translation: CAJ83375.1.
BC127380 mRNA. Translation: AAI27381.1.
RefSeqiNP_001017313.1. NM_001017313.3.
UniGeneiStr.1513.

3D structure databases

ProteinModelPortaliQ28DK1.
SMRiQ28DK1. Positions 30-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020990.

Proteomic databases

PaxDbiQ28DK1.
PRIDEiQ28DK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000020990; ENSXETP00000020990; ENSXETG00000009506.
GeneIDi550067.
KEGGixtr:550067.

Organism-specific databases

CTDi1431.
XenbaseiXB-GENE-943160. cs.

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00390000006813.
HOGENOMiHOG000130831.
HOVERGENiHBG005336.
InParanoidiQ28DK1.
KOiK01647.
OMAiAYEQGDI.
OrthoDBiEOG73BVCB.
TreeFamiTF300398.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.
ReactomeiREACT_290218. Citric acid cycle (TCA cycle).

Gene expression databases

BgeeiQ28DK1.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiCISY_XENTR
AccessioniPrimary (citable) accession number: Q28DK1
Secondary accession number(s): A0JPE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 4, 2006
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.