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Q28DK1

- CISY_XENTR

UniProt

Q28DK1 - CISY_XENTR

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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiREACT_236407. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
ORF Names:TNeu053d23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-943160. cs.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253910Add
BLAST

Proteomic databases

PaxDbiQ28DK1.
PRIDEiQ28DK1.

Expressioni

Gene expression databases

BgeeiQ28DK1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020990.

Structurei

3D structure databases

ProteinModelPortaliQ28DK1.
SMRiQ28DK1. Positions 30-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00390000006813.
HOGENOMiHOG000130831.
HOVERGENiHBG005336.
InParanoidiQ28DK1.
KOiK01647.
OMAiMQKDSKF.
OrthoDBiEOG73BVCB.
TreeFamiTF300398.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28DK1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLITAGRLC ARILGAKNSP CALIAARQAS SSANLKDVLS DLIPKEQTRI
60 70 80 90 100
KNFRQQYGKN VIGQITVDMM YGGMRGMKGL VYETSVLDPD EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA PGGEEPLPEG LFWLLVTGEA PSQEQVNWIS KEWAKRAALP
160 170 180 190 200
SHVVTMLDNF PTNLHPMSQL SAAITALNSE SNFARGYAEG VNKTKYWELI
210 220 230 240 250
YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH NFTNMLGYTD
260 270 280 290 300
PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLTSLQKD LGGEVSDEKL RDYIWNTLNS GRVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGMKEMN YYTVLFGVSR ALGVLAQLIW SRALGFPLER
460
PKSMSTDGLM QLVGSKSG
Length:468
Mass (Da):51,834
Last modified:April 4, 2006 - v1
Checksum:i228AAC80C8D20813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855469 mRNA. Translation: CAJ83375.1.
BC127380 mRNA. Translation: AAI27381.1.
RefSeqiNP_001017313.1. NM_001017313.3.
UniGeneiStr.1513.

Genome annotation databases

EnsembliENSXETT00000020990; ENSXETP00000020990; ENSXETG00000009506.
GeneIDi550067.
KEGGixtr:550067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855469 mRNA. Translation: CAJ83375.1 .
BC127380 mRNA. Translation: AAI27381.1 .
RefSeqi NP_001017313.1. NM_001017313.3.
UniGenei Str.1513.

3D structure databases

ProteinModelPortali Q28DK1.
SMRi Q28DK1. Positions 30-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000020990.

Proteomic databases

PaxDbi Q28DK1.
PRIDEi Q28DK1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000020990 ; ENSXETP00000020990 ; ENSXETG00000009506 .
GeneIDi 550067.
KEGGi xtr:550067.

Organism-specific databases

CTDi 1431.
Xenbasei XB-GENE-943160. cs.

Phylogenomic databases

eggNOGi COG0372.
GeneTreei ENSGT00390000006813.
HOGENOMi HOG000130831.
HOVERGENi HBG005336.
InParanoidi Q28DK1.
KOi K01647.
OMAi MQKDSKF.
OrthoDBi EOG73BVCB.
TreeFami TF300398.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
Reactomei REACT_236407. Citric acid cycle (TCA cycle).

Gene expression databases

Bgeei Q28DK1.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiCISY_XENTR
AccessioniPrimary (citable) accession number: Q28DK1
Secondary accession number(s): A0JPE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 4, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3