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Protein

Myeloid differentiation primary response protein MyD88

Gene

myd88

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88
Gene namesi
Name:myd88
ORF Names:TNeu124j11.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-486650. myd88.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Myeloid differentiation primary response protein MyD88PRO_0000393147Add
BLAST

Proteomic databases

PaxDbiQ28DJ2.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000039929.

Structurei

3D structure databases

ProteinModelPortaliQ28DJ2.
SMRiQ28DJ2. Positions 135-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10579DeathPROSITE-ProRule annotationAdd
BLAST
Domaini147 – 283137TIRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 14338Intermediate domainBy similarityAdd
BLAST

Domaini

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.By similarity

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 1 TIR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
HOGENOMiHOG000068971.
HOVERGENiHBG052547.
InParanoidiQ28DJ2.
KOiK04729.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28DJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGSSLGSV DMNSIPLVAL NYNVRHRLSL YLNPNAVVAA GWTQLAEEMG
60 70 80 90 100
YDYLEIKNFE RFPDCTMKLL EDWEKKCFRA TVGGLLEMLK KMERNDILTD
110 120 130 140 150
LGPLIEADCM KHLEKKNAPL PLQDDKVDSS EQYRITKSDD PSGSLPETFD
160 170 180 190 200
AFICYCAQDI SFVQEMISRL EQTDYKLKLC VFDRDVLPGT CLWSITSELI
210 220 230 240 250
EHRCRKMVVI ISDDYLDSSE CDFQTKFALS LGPGAREKRL IPVKYKPMKR
260 270 280
PFPSILRFIT LCDYTNPCTK GWFWERLAKA LSR
Length:283
Mass (Da):32,505
Last modified:April 4, 2006 - v1
Checksum:i9EC1CF3971384C4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855486 mRNA. Translation: CAJ83053.1.
RefSeqiNP_001016837.1. NM_001016837.2.
UniGeneiStr.11893.

Genome annotation databases

GeneIDi549591.
KEGGixtr:549591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855486 mRNA. Translation: CAJ83053.1.
RefSeqiNP_001016837.1. NM_001016837.2.
UniGeneiStr.11893.

3D structure databases

ProteinModelPortaliQ28DJ2.
SMRiQ28DJ2. Positions 135-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000039929.

Proteomic databases

PaxDbiQ28DJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi549591.
KEGGixtr:549591.

Organism-specific databases

CTDi4615.
XenbaseiXB-GENE-486650. myd88.

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
HOGENOMiHOG000068971.
HOVERGENiHBG052547.
InParanoidiQ28DJ2.
KOiK04729.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYD88_XENTR
AccessioniPrimary (citable) accession number: Q28DJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: April 4, 2006
Last modified: November 11, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.