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Protein

Myeloid differentiation primary response protein MyD88

Gene

myd88

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88
Gene namesi
Name:myd88
ORF Names:TNeu124j11.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-486650 myd88

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003931471 – 283Myeloid differentiation primary response protein MyD88Add BLAST283

Proteomic databases

PaxDbiQ28DJ2
PRIDEiQ28DJ2

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000039929

Structurei

3D structure databases

ProteinModelPortaliQ28DJ2
SMRiQ28DJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 105DeathPROSITE-ProRule annotationAdd BLAST79
Domaini147 – 283TIRPROSITE-ProRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 143Intermediate domainBy similarityAdd BLAST38

Domaini

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.By similarity

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
HOGENOMiHOG000068971
HOVERGENiHBG052547
InParanoidiQ28DJ2
KOiK04729

Family and domain databases

CDDicd08312 Death_MyD88, 1 hit
Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01582 TIR, 1 hit
PIRSFiPIRSF037756 MyD88, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q28DJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGSSLGSV DMNSIPLVAL NYNVRHRLSL YLNPNAVVAA GWTQLAEEMG
60 70 80 90 100
YDYLEIKNFE RFPDCTMKLL EDWEKKCFRA TVGGLLEMLK KMERNDILTD
110 120 130 140 150
LGPLIEADCM KHLEKKNAPL PLQDDKVDSS EQYRITKSDD PSGSLPETFD
160 170 180 190 200
AFICYCAQDI SFVQEMISRL EQTDYKLKLC VFDRDVLPGT CLWSITSELI
210 220 230 240 250
EHRCRKMVVI ISDDYLDSSE CDFQTKFALS LGPGAREKRL IPVKYKPMKR
260 270 280
PFPSILRFIT LCDYTNPCTK GWFWERLAKA LSR
Length:283
Mass (Da):32,505
Last modified:April 4, 2006 - v1
Checksum:i9EC1CF3971384C4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855486 mRNA Translation: CAJ83053.1
RefSeqiNP_001016837.1, NM_001016837.2
UniGeneiStr.11893

Genome annotation databases

GeneIDi549591
KEGGixtr:549591

Similar proteinsi

Entry informationi

Entry nameiMYD88_XENTR
AccessioniPrimary (citable) accession number: Q28DJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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