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Q28DB5

- ALAT2_XENTR

UniProt

Q28DB5 - ALAT2_XENTR

Protein

Alanine aminotransferase 2

Gene

gpt2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.By similarity

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: UniProtKB
    2. biosynthetic process Source: InterPro
    3. L-alanine catabolic process Source: UniProtKB-UniPathway
    4. L-alanine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00528; UER00586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine aminotransferase 2 (EC:2.6.1.2)
    Short name:
    ALT2
    Alternative name(s):
    Glutamate pyruvate transaminase 2
    Short name:
    GPT 2
    Glutamic--alanine transaminase 2
    Glutamic--pyruvic transaminase 2
    Gene namesi
    Name:gpt2
    ORF Names:TEgg035f04.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5824311. gpt2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Alanine aminotransferase 2PRO_0000247536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei342 – 3421N6-(pyridoxal phosphate)lysineBy similarity

    Expressioni

    Gene expression databases

    BgeeiQ28DB5.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000015516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28DB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    GeneTreeiENSGT00650000093331.
    HOGENOMiHOG000215020.
    HOVERGENiHBG026148.
    KOiK00814.
    OMAiQMEDEGH.
    OrthoDBiEOG76HQ18.
    TreeFamiTF300839.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q28DB5-1 [UniParc]FASTAAdd to Basket

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    MDSDLISSRC VWATWNVYNG RSLSGTPLAE RDGKVARKMS ENGTCNRILT    50
    LESMNPCIQK VEYAVRGPIV IRAVELEKEL QQGVKKPFTE VIKANIGDAH 100
    AMGQKPITFL RQVSAICLYP ELMNDNKFPE DVKQKAARIL QACGGHSIGA 150
    YSASQGIEVI RQDVAKYIER RDGGIQSDPN NIYLSTGASD SIVTMLKLLV 200
    SGQGKSRTGV LIPIPQYPLY SAALAELNAV QVNYYLDEEN CWALDINELR 250
    RSLTEARKHC DPKVLCIINP GNPTGQVQSR KCIEDVIRFA AEENLFLMAD 300
    EVYQDNVYAK GCTFHSFKKV LFEMGPKYSE TVELASFHST SKGYMGECGF 350
    RGGYMEVINM DPAVKQQLTK LVSVRLCPPV PGQALLDVIV NPPKPGEPSY 400
    KQFMAEKQAV LGNLAEKARL TEEILNQSPG IRCNPVQGAM YSFPRIHIPE 450
    KAIKLAQAEG QAPDMFFCMK LLEETGICVV PGSGFGQREG THHFRMTILP 500
    PTDKLKSLLE RLKDFHQKFT EEYS 524
    Length:524
    Mass (Da):58,311
    Last modified:April 4, 2006 - v1
    Checksum:iD932C875D2BBA05E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855598 mRNA. Translation: CAJ81963.1.
    RefSeqiNP_001016805.1. NM_001016805.2.
    UniGeneiStr.64694.

    Genome annotation databases

    EnsembliENSXETT00000015516; ENSXETP00000015516; ENSXETG00000007140.
    GeneIDi549559.
    KEGGixtr:549559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855598 mRNA. Translation: CAJ81963.1 .
    RefSeqi NP_001016805.1. NM_001016805.2.
    UniGenei Str.64694.

    3D structure databases

    ProteinModelPortali Q28DB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000015516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000015516 ; ENSXETP00000015516 ; ENSXETG00000007140 .
    GeneIDi 549559.
    KEGGi xtr:549559.

    Organism-specific databases

    CTDi 84706.
    Xenbasei XB-GENE-5824311. gpt2.

    Phylogenomic databases

    eggNOGi COG0436.
    GeneTreei ENSGT00650000093331.
    HOGENOMi HOG000215020.
    HOVERGENi HBG026148.
    KOi K00814.
    OMAi QMEDEGH.
    OrthoDBi EOG76HQ18.
    TreeFami TF300839.

    Enzyme and pathway databases

    UniPathwayi UPA00528 ; UER00586 .

    Gene expression databases

    Bgeei Q28DB5.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.

    Entry informationi

    Entry nameiALAT2_XENTR
    AccessioniPrimary (citable) accession number: Q28DB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3