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Q28DB5 (ALAT2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine aminotransferase 2

Short name=ALT2
EC=2.6.1.2
Alternative name(s):
Glutamate pyruvate transaminase 2
Short name=GPT 2
Glutamic--alanine transaminase 2
Glutamic--pyruvic transaminase 2
Gene names
Name:gpt2
ORF Names:TEgg035f04.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate By similarity.

Catalytic activity

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Alanine aminotransferase 2
PRO_0000247536

Amino acid modifications

Modified residue3421N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28DB5 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: D932C875D2BBA05E

FASTA52458,311
        10         20         30         40         50         60 
MDSDLISSRC VWATWNVYNG RSLSGTPLAE RDGKVARKMS ENGTCNRILT LESMNPCIQK 

        70         80         90        100        110        120 
VEYAVRGPIV IRAVELEKEL QQGVKKPFTE VIKANIGDAH AMGQKPITFL RQVSAICLYP 

       130        140        150        160        170        180 
ELMNDNKFPE DVKQKAARIL QACGGHSIGA YSASQGIEVI RQDVAKYIER RDGGIQSDPN 

       190        200        210        220        230        240 
NIYLSTGASD SIVTMLKLLV SGQGKSRTGV LIPIPQYPLY SAALAELNAV QVNYYLDEEN 

       250        260        270        280        290        300 
CWALDINELR RSLTEARKHC DPKVLCIINP GNPTGQVQSR KCIEDVIRFA AEENLFLMAD 

       310        320        330        340        350        360 
EVYQDNVYAK GCTFHSFKKV LFEMGPKYSE TVELASFHST SKGYMGECGF RGGYMEVINM 

       370        380        390        400        410        420 
DPAVKQQLTK LVSVRLCPPV PGQALLDVIV NPPKPGEPSY KQFMAEKQAV LGNLAEKARL 

       430        440        450        460        470        480 
TEEILNQSPG IRCNPVQGAM YSFPRIHIPE KAIKLAQAEG QAPDMFFCMK LLEETGICVV 

       490        500        510        520 
PGSGFGQREG THHFRMTILP PTDKLKSLLE RLKDFHQKFT EEYS 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR855598 mRNA. Translation: CAJ81963.1.
RefSeqNP_001016805.1. NM_001016805.2.
UniGeneStr.64694.

3D structure databases

ProteinModelPortalQ28DB5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000015516.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000015516; ENSXETP00000015516; ENSXETG00000007140.
GeneID549559.
KEGGxtr:549559.

Organism-specific databases

CTD84706.
XenbaseXB-GENE-5824311. gpt2.

Phylogenomic databases

eggNOGCOG0436.
GeneTreeENSGT00650000093331.
HOGENOMHOG000215020.
HOVERGENHBG026148.
KOK00814.
OMACDEENNW.
OrthoDBEOG76HQ18.
TreeFamTF300839.

Enzyme and pathway databases

UniPathwayUPA00528; UER00586.

Gene expression databases

BgeeQ28DB5.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALAT2_XENTR
AccessionPrimary (citable) accession number: Q28DB5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways