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Protein

Alanine aminotransferase 2

Gene

gpt2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.By similarity

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathway:iL-alanine degradation via transaminase pathway

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine aminotransferase 2 (gpt2)
This subpathway is part of the pathway L-alanine degradation via transaminase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from L-alanine, the pathway L-alanine degradation via transaminase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_311171. Amino acid synthesis and interconversion (transamination).
UniPathwayiUPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine aminotransferase 2 (EC:2.6.1.2)
Short name:
ALT2
Alternative name(s):
Glutamate pyruvate transaminase 2
Short name:
GPT 2
Glutamic--alanine transaminase 2
Glutamic--pyruvic transaminase 2
Gene namesi
Name:gpt2
ORF Names:TEgg035f04.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5824311. gpt2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Alanine aminotransferase 2PRO_0000247536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei342 – 3421N6-(pyridoxal phosphate)lysineBy similarity

Expressioni

Gene expression databases

BgeeiQ28DB5.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015516.

Structurei

3D structure databases

ProteinModelPortaliQ28DB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
GeneTreeiENSGT00650000093331.
HOGENOMiHOG000215020.
HOVERGENiHBG026148.
InParanoidiQ28DB5.
KOiK00814.
OMAiQKIREFH.
OrthoDBiEOG76HQ18.
TreeFamiTF300839.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28DB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDLISSRC VWATWNVYNG RSLSGTPLAE RDGKVARKMS ENGTCNRILT
60 70 80 90 100
LESMNPCIQK VEYAVRGPIV IRAVELEKEL QQGVKKPFTE VIKANIGDAH
110 120 130 140 150
AMGQKPITFL RQVSAICLYP ELMNDNKFPE DVKQKAARIL QACGGHSIGA
160 170 180 190 200
YSASQGIEVI RQDVAKYIER RDGGIQSDPN NIYLSTGASD SIVTMLKLLV
210 220 230 240 250
SGQGKSRTGV LIPIPQYPLY SAALAELNAV QVNYYLDEEN CWALDINELR
260 270 280 290 300
RSLTEARKHC DPKVLCIINP GNPTGQVQSR KCIEDVIRFA AEENLFLMAD
310 320 330 340 350
EVYQDNVYAK GCTFHSFKKV LFEMGPKYSE TVELASFHST SKGYMGECGF
360 370 380 390 400
RGGYMEVINM DPAVKQQLTK LVSVRLCPPV PGQALLDVIV NPPKPGEPSY
410 420 430 440 450
KQFMAEKQAV LGNLAEKARL TEEILNQSPG IRCNPVQGAM YSFPRIHIPE
460 470 480 490 500
KAIKLAQAEG QAPDMFFCMK LLEETGICVV PGSGFGQREG THHFRMTILP
510 520
PTDKLKSLLE RLKDFHQKFT EEYS
Length:524
Mass (Da):58,311
Last modified:April 4, 2006 - v1
Checksum:iD932C875D2BBA05E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855598 mRNA. Translation: CAJ81963.1.
RefSeqiNP_001016805.1. NM_001016805.2.
UniGeneiStr.64694.

Genome annotation databases

EnsembliENSXETT00000015516; ENSXETP00000015516; ENSXETG00000007140.
GeneIDi549559.
KEGGixtr:549559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855598 mRNA. Translation: CAJ81963.1.
RefSeqiNP_001016805.1. NM_001016805.2.
UniGeneiStr.64694.

3D structure databases

ProteinModelPortaliQ28DB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000015516; ENSXETP00000015516; ENSXETG00000007140.
GeneIDi549559.
KEGGixtr:549559.

Organism-specific databases

CTDi84706.
XenbaseiXB-GENE-5824311. gpt2.

Phylogenomic databases

eggNOGiCOG0436.
GeneTreeiENSGT00650000093331.
HOGENOMiHOG000215020.
HOVERGENiHBG026148.
InParanoidiQ28DB5.
KOiK00814.
OMAiQKIREFH.
OrthoDBiEOG76HQ18.
TreeFamiTF300839.

Enzyme and pathway databases

UniPathwayiUPA00528; UER00586.
ReactomeiREACT_311171. Amino acid synthesis and interconversion (transamination).

Gene expression databases

BgeeiQ28DB5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiALAT2_XENTR
AccessioniPrimary (citable) accession number: Q28DB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 4, 2006
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.