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Q28D84

- EZH2_XENTR

UniProt

Q28D84 - EZH2_XENTR

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Protein

Histone-lysine N-methyltransferase EZH2

Gene
ezh2, TGas092f05.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein By similarity. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZH2 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste homolog 2
Gene namesi
Name:ezh2
ORF Names:TGas092f05.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-956215. ezh2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. ESC/E(Z) complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Histone-lysine N-methyltransferase EZH2PRO_0000345430Add
BLAST

Proteomic databases

PaxDbiQ28D84.

Interactioni

Subunit structurei

Component of the prc2/eed-ezh2 complex By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043460.

Structurei

3D structure databases

ProteinModelPortaliQ28D84.
SMRiQ28D84. Positions 40-68.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini505 – 607103CXCAdd
BLAST
Domaini614 – 729116SETAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 21129Asp-richAdd
BLAST
Compositional biasi525 – 59066Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 CXC domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiNOG303400.
HOVERGENiHBG002453.
KOiK11430.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28D84-1 [UniParc]FASTAAdd to Basket

« Hide

MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFNTNRQKIM    50
ERTEILNQEW KQRRIQPVHI MTTVSSLRGT RECSVTSDLD FPKQVIPLKT 100
LTAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI 150
KNYDGKVHGD RECGFINDEI FVELVNALAQ YSDYEDDEDG DDNQDDERDD 200
TAKDQDDNME DQETQPLRKF PSDKIFEAIS SMFPDKGTLE ELKEKYKELT 250
EQQLPGALPP ECTPNIDGPN AKSVQREQSL HSFHTLFCRR CFKYDCFLHP 300
FHATPNTYKR KNNEAANDGK PCGPHCYQLL EGAREFAAAL TAERIKTPPK 350
RPSGRRRGRL PNNTSRPSTP TVNVLEAKDT DSDREAGTET GGESNDKEEE 400
EKKDETSSSS EANSRCQTPI KMKPNIEPPE NVEWSGAEAS LFRVLIGTYY 450
DNFCAIARLI GTKTCRQVYE FRVKESSIIA PVIAEDVDTP PRKKKRKHRL 500
WAAHCRKIQL KKDGSSNHVY NYQPCDHPRQ PCDSSCPCVI AQNFCEKFCQ 550
CSSECQNRFP GCRCKAQCNT KQCPCYLAVR ECDPDLCLTC GAADHWDSKN 600
VSCKNCSIQR GSKKHLLLAP SDVAGWGIFI KDPVQKNEFI SEYCGEIISQ 650
DEADRRGKVY DKYMCSFLFN LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK 700
VMMVNGDHRI GIFAKRAIQT GEELFFDYRY SQADALKYVG IEREMEIP 748
Length:748
Mass (Da):85,630
Last modified:April 4, 2006 - v1
Checksum:i0D6D3FDE6C329CD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR855647 mRNA. Translation: CAJ83863.1.
RefSeqiNP_001017293.1. NM_001017293.2.
UniGeneiStr.1297.

Genome annotation databases

GeneIDi550047.
KEGGixtr:550047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR855647 mRNA. Translation: CAJ83863.1 .
RefSeqi NP_001017293.1. NM_001017293.2.
UniGenei Str.1297.

3D structure databases

ProteinModelPortali Q28D84.
SMRi Q28D84. Positions 40-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000043460.

Proteomic databases

PaxDbi Q28D84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 550047.
KEGGi xtr:550047.

Organism-specific databases

CTDi 2146.
Xenbasei XB-GENE-956215. ezh2.

Phylogenomic databases

eggNOGi NOG303400.
HOVERGENi HBG002453.
KOi K11430.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.

Entry informationi

Entry nameiEZH2_XENTR
AccessioniPrimary (citable) accession number: Q28D84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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