Reviewed,
UniProtKB/Swiss-Prot Q28D84 (EZH2_XENTR)
Last modified
June 16, 2009.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone-lysine N-methyltransferase EZH2 EC=2.1.1.43 Alternative name(s): Enhancer of zeste homolog 2 | ||||
| Gene names |
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| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | ||||
| Taxonomic identifier | 8364 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Protein attributes
| Sequence length | 748 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Polycomb group (PcG) protein By similarity. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. |
| Subunit structure | Component of the prc2/eed-ezh2 complex By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 SET domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Chromatin regulator Methyltransferase Repressor Transferase |
| Gene Ontology (GO) | |
| Biological process | chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastrula. |
Cross-references
Sequence databases | |
|---|---|
| CR855647 mRNA. Translation: CAJ83863.1. | |
| RefSeq | NP_001017293.1. |
| UniGene | Str.1297 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 550047. |
| KEGG | xtr:550047. |
Organism-specific databases | |
| Xenbase | XB-FEAT-956214. ezh2. |
Phylogenomic databases | |
| HOVERGEN | Q28D84. |
Family and domain databases | |
| InterPro | IPR001005. SANT_DNA-bd. IPR001214. SET. [Graphical view] |
| Pfam | PF00856. SET. 1 hit. [Graphical view] |
| SMART | SM00717. SANT. 2 hits. SM00317. SET. 1 hit. [Graphical view] |
| PROSITE | PS50280. SET. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | EZH2_XENTR | ||||||||
| Accession | Primary (citable) accession number: Q28D84 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

Clusters with


