Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q28D84

- EZH2_XENTR

UniProt

Q28D84 - EZH2_XENTR

Protein

Histone-lysine N-methyltransferase EZH2

Gene

ezh2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase EZH2 (EC:2.1.1.43)
    Alternative name(s):
    Enhancer of zeste homolog 2
    Gene namesi
    Name:ezh2
    ORF Names:TGas092f05.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-956215. ezh2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. ESC/E(Z) complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 748748Histone-lysine N-methyltransferase EZH2PRO_0000345430Add
    BLAST

    Proteomic databases

    PaxDbiQ28D84.

    Interactioni

    Subunit structurei

    Component of the prc2/eed-ezh2 complex.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000043460.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28D84.
    SMRiQ28D84. Positions 40-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini505 – 607103CXCPROSITE-ProRule annotationAdd
    BLAST
    Domaini614 – 729116SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi183 – 21129Asp-richAdd
    BLAST
    Compositional biasi525 – 59066Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
    Contains 1 CXC domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303400.
    HOVERGENiHBG002453.
    KOiK11430.

    Family and domain databases

    InterProiIPR026489. CXC_dom.
    IPR021654. EZH2_WD-Binding.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11616. EZH2_WD-Binding. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51633. CXC. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28D84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFNTNRQKIM    50
    ERTEILNQEW KQRRIQPVHI MTTVSSLRGT RECSVTSDLD FPKQVIPLKT 100
    LTAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI 150
    KNYDGKVHGD RECGFINDEI FVELVNALAQ YSDYEDDEDG DDNQDDERDD 200
    TAKDQDDNME DQETQPLRKF PSDKIFEAIS SMFPDKGTLE ELKEKYKELT 250
    EQQLPGALPP ECTPNIDGPN AKSVQREQSL HSFHTLFCRR CFKYDCFLHP 300
    FHATPNTYKR KNNEAANDGK PCGPHCYQLL EGAREFAAAL TAERIKTPPK 350
    RPSGRRRGRL PNNTSRPSTP TVNVLEAKDT DSDREAGTET GGESNDKEEE 400
    EKKDETSSSS EANSRCQTPI KMKPNIEPPE NVEWSGAEAS LFRVLIGTYY 450
    DNFCAIARLI GTKTCRQVYE FRVKESSIIA PVIAEDVDTP PRKKKRKHRL 500
    WAAHCRKIQL KKDGSSNHVY NYQPCDHPRQ PCDSSCPCVI AQNFCEKFCQ 550
    CSSECQNRFP GCRCKAQCNT KQCPCYLAVR ECDPDLCLTC GAADHWDSKN 600
    VSCKNCSIQR GSKKHLLLAP SDVAGWGIFI KDPVQKNEFI SEYCGEIISQ 650
    DEADRRGKVY DKYMCSFLFN LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK 700
    VMMVNGDHRI GIFAKRAIQT GEELFFDYRY SQADALKYVG IEREMEIP 748
    Length:748
    Mass (Da):85,630
    Last modified:April 4, 2006 - v1
    Checksum:i0D6D3FDE6C329CD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855647 mRNA. Translation: CAJ83863.1.
    RefSeqiNP_001017293.1. NM_001017293.2.
    UniGeneiStr.1297.

    Genome annotation databases

    GeneIDi550047.
    KEGGixtr:550047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855647 mRNA. Translation: CAJ83863.1 .
    RefSeqi NP_001017293.1. NM_001017293.2.
    UniGenei Str.1297.

    3D structure databases

    ProteinModelPortali Q28D84.
    SMRi Q28D84. Positions 40-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000043460.

    Proteomic databases

    PaxDbi Q28D84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 550047.
    KEGGi xtr:550047.

    Organism-specific databases

    CTDi 2146.
    Xenbasei XB-GENE-956215. ezh2.

    Phylogenomic databases

    eggNOGi NOG303400.
    HOVERGENi HBG002453.
    KOi K11430.

    Family and domain databases

    InterProi IPR026489. CXC_dom.
    IPR021654. EZH2_WD-Binding.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11616. EZH2_WD-Binding. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51633. CXC. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula.

    Entry informationi

    Entry nameiEZH2_XENTR
    AccessioniPrimary (citable) accession number: Q28D84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3