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Q28D84 (EZH2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase EZH2

EC=2.1.1.43
Alternative name(s):
Enhancer of zeste homolog 2
Gene names
Name:ezh2
ORF Names:TGas092f05.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length748 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Polycomb group (PcG) protein By similarity. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Component of the prc2/eed-ezh2 complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.

Contains 1 CXC domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 748748Histone-lysine N-methyltransferase EZH2
PRO_0000345430

Regions

Domain505 – 607103CXC
Domain614 – 729116SET
Compositional bias183 – 21129Asp-rich
Compositional bias525 – 59066Cys-rich

Sequences

Sequence LengthMass (Da)Tools
Q28D84 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 0D6D3FDE6C329CD1

FASTA74885,630
        10         20         30         40         50         60 
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFNTNRQKIM ERTEILNQEW 

        70         80         90        100        110        120 
KQRRIQPVHI MTTVSSLRGT RECSVTSDLD FPKQVIPLKT LTAVASVPIM YSWSPLQQNF 

       130        140        150        160        170        180 
MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALAQ 

       190        200        210        220        230        240 
YSDYEDDEDG DDNQDDERDD TAKDQDDNME DQETQPLRKF PSDKIFEAIS SMFPDKGTLE 

       250        260        270        280        290        300 
ELKEKYKELT EQQLPGALPP ECTPNIDGPN AKSVQREQSL HSFHTLFCRR CFKYDCFLHP 

       310        320        330        340        350        360 
FHATPNTYKR KNNEAANDGK PCGPHCYQLL EGAREFAAAL TAERIKTPPK RPSGRRRGRL 

       370        380        390        400        410        420 
PNNTSRPSTP TVNVLEAKDT DSDREAGTET GGESNDKEEE EKKDETSSSS EANSRCQTPI 

       430        440        450        460        470        480 
KMKPNIEPPE NVEWSGAEAS LFRVLIGTYY DNFCAIARLI GTKTCRQVYE FRVKESSIIA 

       490        500        510        520        530        540 
PVIAEDVDTP PRKKKRKHRL WAAHCRKIQL KKDGSSNHVY NYQPCDHPRQ PCDSSCPCVI 

       550        560        570        580        590        600 
AQNFCEKFCQ CSSECQNRFP GCRCKAQCNT KQCPCYLAVR ECDPDLCLTC GAADHWDSKN 

       610        620        630        640        650        660 
VSCKNCSIQR GSKKHLLLAP SDVAGWGIFI KDPVQKNEFI SEYCGEIISQ DEADRRGKVY 

       670        680        690        700        710        720 
DKYMCSFLFN LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK VMMVNGDHRI GIFAKRAIQT 

       730        740 
GEELFFDYRY SQADALKYVG IEREMEIP 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR855647 mRNA. Translation: CAJ83863.1.
RefSeqNP_001017293.1. NM_001017293.2.
UniGeneStr.1297.

3D structure databases

ProteinModelPortalQ28D84.
SMRQ28D84. Positions 40-68.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000043460.

Proteomic databases

PaxDbQ28D84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID550047.
KEGGxtr:550047.

Organism-specific databases

CTD2146.
XenbaseXB-GENE-956215. ezh2.

Phylogenomic databases

eggNOGNOG303400.
HOVERGENHBG002453.
KOK11430.

Family and domain databases

InterProIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEZH2_XENTR
AccessionPrimary (citable) accession number: Q28D84
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families