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Q28D84

- EZH2_XENTR

UniProt

Q28D84 - EZH2_XENTR

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Protein

Histone-lysine N-methyltransferase EZH2

Gene

ezh2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZH2 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste homolog 2
Gene namesi
Name:ezh2
ORF Names:TGas092f05.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-956215. ezh2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. ESC/E(Z) complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Histone-lysine N-methyltransferase EZH2PRO_0000345430Add
BLAST

Proteomic databases

PaxDbiQ28D84.

Interactioni

Subunit structurei

Component of the prc2/eed-ezh2 complex.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043460.

Structurei

3D structure databases

ProteinModelPortaliQ28D84.
SMRiQ28D84. Positions 40-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini505 – 607103CXCPROSITE-ProRule annotationAdd
BLAST
Domaini614 – 729116SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 21129Asp-richAdd
BLAST
Compositional biasi525 – 59066Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
Contains 1 CXC domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG303400.
HOVERGENiHBG002453.
InParanoidiQ28D84.
KOiK11430.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28D84 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFNTNRQKIM
60 70 80 90 100
ERTEILNQEW KQRRIQPVHI MTTVSSLRGT RECSVTSDLD FPKQVIPLKT
110 120 130 140 150
LTAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
160 170 180 190 200
KNYDGKVHGD RECGFINDEI FVELVNALAQ YSDYEDDEDG DDNQDDERDD
210 220 230 240 250
TAKDQDDNME DQETQPLRKF PSDKIFEAIS SMFPDKGTLE ELKEKYKELT
260 270 280 290 300
EQQLPGALPP ECTPNIDGPN AKSVQREQSL HSFHTLFCRR CFKYDCFLHP
310 320 330 340 350
FHATPNTYKR KNNEAANDGK PCGPHCYQLL EGAREFAAAL TAERIKTPPK
360 370 380 390 400
RPSGRRRGRL PNNTSRPSTP TVNVLEAKDT DSDREAGTET GGESNDKEEE
410 420 430 440 450
EKKDETSSSS EANSRCQTPI KMKPNIEPPE NVEWSGAEAS LFRVLIGTYY
460 470 480 490 500
DNFCAIARLI GTKTCRQVYE FRVKESSIIA PVIAEDVDTP PRKKKRKHRL
510 520 530 540 550
WAAHCRKIQL KKDGSSNHVY NYQPCDHPRQ PCDSSCPCVI AQNFCEKFCQ
560 570 580 590 600
CSSECQNRFP GCRCKAQCNT KQCPCYLAVR ECDPDLCLTC GAADHWDSKN
610 620 630 640 650
VSCKNCSIQR GSKKHLLLAP SDVAGWGIFI KDPVQKNEFI SEYCGEIISQ
660 670 680 690 700
DEADRRGKVY DKYMCSFLFN LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK
710 720 730 740
VMMVNGDHRI GIFAKRAIQT GEELFFDYRY SQADALKYVG IEREMEIP
Length:748
Mass (Da):85,630
Last modified:April 4, 2006 - v1
Checksum:i0D6D3FDE6C329CD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR855647 mRNA. Translation: CAJ83863.1.
RefSeqiNP_001017293.1. NM_001017293.2.
UniGeneiStr.1297.

Genome annotation databases

GeneIDi550047.
KEGGixtr:550047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR855647 mRNA. Translation: CAJ83863.1 .
RefSeqi NP_001017293.1. NM_001017293.2.
UniGenei Str.1297.

3D structure databases

ProteinModelPortali Q28D84.
SMRi Q28D84. Positions 40-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000043460.

Proteomic databases

PaxDbi Q28D84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 550047.
KEGGi xtr:550047.

Organism-specific databases

CTDi 2146.
Xenbasei XB-GENE-956215. ezh2.

Phylogenomic databases

eggNOGi NOG303400.
HOVERGENi HBG002453.
InParanoidi Q28D84.
KOi K11430.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.

Entry informationi

Entry nameiEZH2_XENTR
AccessioniPrimary (citable) accession number: Q28D84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3