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Q28CQ7

- SUV92_XENTR

UniProt

Q28CQ7 - SUV92_XENTR

Protein

Histone-lysine N-methyltransferase SUV39H2

Gene

suv39h2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Zinc 1By similarity
    Metal bindingi187 – 1871Zinc 2By similarity
    Metal bindingi189 – 1891Zinc 1By similarity
    Metal bindingi192 – 1921Zinc 1By similarity
    Metal bindingi192 – 1921Zinc 3By similarity
    Metal bindingi197 – 1971Zinc 1By similarity
    Metal bindingi198 – 1981Zinc 1By similarity
    Metal bindingi198 – 1981Zinc 2By similarity
    Metal bindingi225 – 2251Zinc 2By similarity
    Metal bindingi225 – 2251Zinc 3By similarity
    Metal bindingi229 – 2291Zinc 2By similarity
    Metal bindingi231 – 2311Zinc 3By similarity
    Metal bindingi235 – 2351Zinc 3By similarity
    Binding sitei300 – 3001S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi329 – 3291Zinc 4By similarity
    Metal bindingi394 – 3941Zinc 4By similarity
    Metal bindingi396 – 3961Zinc 4By similarity
    Metal bindingi401 – 4011Zinc 4By similarity

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Cell cycle, Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.43)
    Alternative name(s):
    Suppressor of variegation 3-9 homolog 2
    Short name:
    Su(var)3-9 homolog 2
    Gene namesi
    Name:suv39h2
    ORF Names:TEgg055l20.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-852675. suv39h2.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity
    Note: Associates with centromeric constitutive heterochromatin.By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Histone-lysine N-methyltransferase SUV39H2PRO_0000281816Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000011888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28CQ7.
    SMRiQ28CQ7. Positions 120-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 10159ChromoPROSITE-ProRule annotationAdd
    BLAST
    Domaini185 – 24359Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini246 – 369124SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini390 – 40617Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni257 – 2593S-adenosyl-L-methionine bindingBy similarity
    Regioni326 – 3272S-adenosyl-L-methionine bindingBy similarity

    Domaini

    Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin By similarity.By similarity
    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
    Contains 1 chromo domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000231244.
    HOVERGENiHBG055621.
    KOiK11419.

    Family and domain databases

    InterProiIPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR011381. Histone_H3-K9_MeTrfase.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00385. Chromo. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009343. SUV39_SET. 1 hit.
    SMARTiSM00298. CHROMO. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51579. SAM_MT43_SUVAR39_3. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28CQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAARGAWCV PCLASIETLQ ELCRKEMLIC TNIGITRKNL NNYEVEYLCD    50
    YRIEKGVEKF FVKWKGWPES CNTWEPTRNL KCPTLLKQFY SDLYNYFCAL 100
    KPNKKGFLKN SIKSLDPSLS DYIVKKAKQR IALRRWEEEL NRKKTHSGTL 150
    FVENTVDLEG PPMDFYYIND YKASPGVNTL GEAIVGCDCS DCFKGKCCPT 200
    EAGVLFAYNE HRQIKIPPGR PIYECNSRCK CGPDCPNRVV QKGPPYSLCI 250
    FRTDNGRGWG VKTLQKIKKN SFVMEYVGEV ITSEEAERRG QQYDSRGITY 300
    LFDLDYEADE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDVRLPRI 350
    ALFSTRNIKA GEELTFDYQM KGSGDFSTDS IDMSPAKKRV RIACKCGAAT 400
    CRGYLN 406
    Length:406
    Mass (Da):46,350
    Last modified:April 3, 2007 - v2
    Checksum:iE8AF03619B8AF75B
    GO

    Sequence cautioni

    The sequence CAJ81421.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926249 mRNA. Translation: CAJ81421.1. Different initiation.
    RefSeqiNP_001016508.1. NM_001016508.1.
    UniGeneiStr.423.

    Genome annotation databases

    GeneIDi549262.
    KEGGixtr:549262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926249 mRNA. Translation: CAJ81421.1 . Different initiation.
    RefSeqi NP_001016508.1. NM_001016508.1.
    UniGenei Str.423.

    3D structure databases

    ProteinModelPortali Q28CQ7.
    SMRi Q28CQ7. Positions 120-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000011888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 549262.
    KEGGi xtr:549262.

    Organism-specific databases

    CTDi 79723.
    Xenbasei XB-GENE-852675. suv39h2.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000231244.
    HOVERGENi HBG055621.
    KOi K11419.

    Family and domain databases

    InterProi IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR011381. Histone_H3-K9_MeTrfase.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00385. Chromo. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009343. SUV39_SET. 1 hit.
    SMARTi SM00298. CHROMO. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51579. SAM_MT43_SUVAR39_3. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.

    Entry informationi

    Entry nameiSUV92_XENTR
    AccessioniPrimary (citable) accession number: Q28CQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3