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Q28CQ7 (SUV92_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SUV39H2

EC=2.1.1.43
Alternative name(s):
Suppressor of variegation 3-9 homolog 2
Short name=Su(var)3-9 homolog 2
Gene names
Name:suv39h2
ORF Names:TEgg055l20.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 chromo domain.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Sequence caution

The sequence CAJ81421.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Histone-lysine N-methyltransferase SUV39H2
PRO_0000281816

Regions

Domain43 – 10159Chromo
Domain185 – 24359Pre-SET
Domain246 – 369124SET
Domain390 – 40617Post-SET

Sequences

Sequence LengthMass (Da)Tools
Q28CQ7 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: E8AF03619B8AF75B

FASTA40646,350
        10         20         30         40         50         60 
MAAARGAWCV PCLASIETLQ ELCRKEMLIC TNIGITRKNL NNYEVEYLCD YRIEKGVEKF 

        70         80         90        100        110        120 
FVKWKGWPES CNTWEPTRNL KCPTLLKQFY SDLYNYFCAL KPNKKGFLKN SIKSLDPSLS 

       130        140        150        160        170        180 
DYIVKKAKQR IALRRWEEEL NRKKTHSGTL FVENTVDLEG PPMDFYYIND YKASPGVNTL 

       190        200        210        220        230        240 
GEAIVGCDCS DCFKGKCCPT EAGVLFAYNE HRQIKIPPGR PIYECNSRCK CGPDCPNRVV 

       250        260        270        280        290        300 
QKGPPYSLCI FRTDNGRGWG VKTLQKIKKN SFVMEYVGEV ITSEEAERRG QQYDSRGITY 

       310        320        330        340        350        360 
LFDLDYEADE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDVRLPRI ALFSTRNIKA 

       370        380        390        400 
GEELTFDYQM KGSGDFSTDS IDMSPAKKRV RIACKCGAAT CRGYLN 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR926249 mRNA. Translation: CAJ81421.1. Different initiation.
RefSeqNP_001016508.1. NM_001016508.1.
UniGeneStr.423.

3D structure databases

ProteinModelPortalQ28CQ7.
SMRQ28CQ7. Positions 120-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000011888.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID549262.
KEGGxtr:549262.

Organism-specific databases

CTD79723.
XenbaseXB-GENE-852675. suv39h2.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000231244.
HOVERGENHBG055621.
KOK11419.

Family and domain databases

InterProIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFPIRSF009343. SUV39_SET. 1 hit.
SMARTSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF54160. SSF54160. 1 hit.
PROSITEPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUV92_XENTR
AccessionPrimary (citable) accession number: Q28CQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families