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Q28CQ7

- SUV92_XENTR

UniProt

Q28CQ7 - SUV92_XENTR

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Protein
Histone-lysine N-methyltransferase SUV39H2
Gene
suv39h2, TEgg055l20.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc 1 By similarity
Metal bindingi187 – 1871Zinc 2 By similarity
Metal bindingi189 – 1891Zinc 1 By similarity
Metal bindingi192 – 1921Zinc 1 By similarity
Metal bindingi192 – 1921Zinc 3 By similarity
Metal bindingi197 – 1971Zinc 1 By similarity
Metal bindingi198 – 1981Zinc 1 By similarity
Metal bindingi198 – 1981Zinc 2 By similarity
Metal bindingi225 – 2251Zinc 2 By similarity
Metal bindingi225 – 2251Zinc 3 By similarity
Metal bindingi229 – 2291Zinc 2 By similarity
Metal bindingi231 – 2311Zinc 3 By similarity
Metal bindingi235 – 2351Zinc 3 By similarity
Binding sitei300 – 3001S-adenosyl-L-methionine By similarity
Metal bindingi329 – 3291Zinc 4 By similarity
Metal bindingi394 – 3941Zinc 4 By similarity
Metal bindingi396 – 3961Zinc 4 By similarity
Metal bindingi401 – 4011Zinc 4 By similarity

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Cell cycle, Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.43)
Alternative name(s):
Suppressor of variegation 3-9 homolog 2
Short name:
Su(var)3-9 homolog 2
Gene namesi
Name:suv39h2
ORF Names:TEgg055l20.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-852675. suv39h2.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity
Note: Associates with centromeric constitutive heterochromatin By similarity.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Histone-lysine N-methyltransferase SUV39H2
PRO_0000281816Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000011888.

Structurei

3D structure databases

ProteinModelPortaliQ28CQ7.
SMRiQ28CQ7. Positions 120-406.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 10159Chromo
Add
BLAST
Domaini185 – 24359Pre-SET
Add
BLAST
Domaini246 – 369124SET
Add
BLAST
Domaini390 – 40617Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2593S-adenosyl-L-methionine binding By similarity
Regioni326 – 3272S-adenosyl-L-methionine binding By similarity

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin By similarity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 chromo domain.
Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000231244.
HOVERGENiHBG055621.
KOiK11419.

Family and domain databases

InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28CQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAARGAWCV PCLASIETLQ ELCRKEMLIC TNIGITRKNL NNYEVEYLCD    50
YRIEKGVEKF FVKWKGWPES CNTWEPTRNL KCPTLLKQFY SDLYNYFCAL 100
KPNKKGFLKN SIKSLDPSLS DYIVKKAKQR IALRRWEEEL NRKKTHSGTL 150
FVENTVDLEG PPMDFYYIND YKASPGVNTL GEAIVGCDCS DCFKGKCCPT 200
EAGVLFAYNE HRQIKIPPGR PIYECNSRCK CGPDCPNRVV QKGPPYSLCI 250
FRTDNGRGWG VKTLQKIKKN SFVMEYVGEV ITSEEAERRG QQYDSRGITY 300
LFDLDYEADE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDVRLPRI 350
ALFSTRNIKA GEELTFDYQM KGSGDFSTDS IDMSPAKKRV RIACKCGAAT 400
CRGYLN 406
Length:406
Mass (Da):46,350
Last modified:April 3, 2007 - v2
Checksum:iE8AF03619B8AF75B
GO

Sequence cautioni

The sequence CAJ81421.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926249 mRNA. Translation: CAJ81421.1. Different initiation.
RefSeqiNP_001016508.1. NM_001016508.1.
UniGeneiStr.423.

Genome annotation databases

GeneIDi549262.
KEGGixtr:549262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926249 mRNA. Translation: CAJ81421.1 . Different initiation.
RefSeqi NP_001016508.1. NM_001016508.1.
UniGenei Str.423.

3D structure databases

ProteinModelPortali Q28CQ7.
SMRi Q28CQ7. Positions 120-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000011888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 549262.
KEGGi xtr:549262.

Organism-specific databases

CTDi 79723.
Xenbasei XB-GENE-852675. suv39h2.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000231244.
HOVERGENi HBG055621.
KOi K11419.

Family and domain databases

InterProi IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF009343. SUV39_SET. 1 hit.
SMARTi SM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiSUV92_XENTR
AccessioniPrimary (citable) accession number: Q28CQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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