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Q28CL4 (IMPA3_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol monophosphatase 3
Short name=IMP 3
Short name=IMPase 3
EC=3.1.3.25
Alternative name(s):
Inositol monophosphatase domain-containing protein 1
Inositol-1(or 4)-monophosphatase 3
Myo-inositol monophosphatase A3
Gene names
Name:impad1
Synonyms:impa3
ORF Names:TEgg066b01.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the inositol monophosphatase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioninositol monophosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Inositol monophosphatase 3
PRO_0000289045

Regions

Transmembrane11 – 3121Helical; Potential
Region169 – 1724Substrate binding By similarity

Sites

Metal binding1271Magnesium 1 By similarity
Metal binding1671Magnesium 1 By similarity
Metal binding1671Magnesium 2 By similarity
Metal binding1691Magnesium 1; via carbonyl oxygen By similarity
Metal binding1701Magnesium 2 By similarity
Metal binding2931Magnesium 2 By similarity
Binding site1271Substrate By similarity
Binding site2931Substrate By similarity

Experimental info

Sequence conflict3441S → A in AAH80464. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q28CL4 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: EC57250FF884BB63

FASTA35638,720
        10         20         30         40         50         60 
MAPMGIRLSP LGIGVFCLLG LGVLYHVYSG FLTGKFSAFL LGDRAEDPGP GEDTVDLREL 

        70         80         90        100        110        120 
LAVSVRAAEL GGLEVKKVRE SNSLNEKAKG KTMEGADDKM TSGDVLSNKK MYHLIKNAFP 

       130        140        150        160        170        180 
ALKVNTEEKV EADDEDAVSW DRNIPDDIKE QIKTKHVASE SITMWIDPLD ATQEYTENLV 

       190        200        210        220        230        240 
NYVTTMVCVA VNGKPVIGVI HKPFTGFTAW AMLDGGSSIK KRNSYNEKTP TFIVSRSHSG 

       250        260        270        280        290        300 
EVKEVTRQTF GNKTEIISAG GAGYKVLSLL DVTDDKQETA DVYIHVTYIK KWDICAGNAI 

       310        320        330        340        350 
LNALGGQMTT LKGEEIMYTG SELNKGGLLA SIGMDHGVLV EKLSEKLQVN AKKPAK

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR926321 mRNA. Translation: CAJ82287.1.
BC080464 mRNA. Translation: AAH80464.1.
RefSeqNP_001016215.2. NM_001016215.3.
UniGeneStr.7052.

3D structure databases

ProteinModelPortalQ28CL4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID548969.
KEGGxtr:548969.

Organism-specific databases

CTD54928.
XenbaseXB-GENE-5751033. impad1.

Phylogenomic databases

eggNOGveNOG09613.
GeneTreeENSGT00530000063462.
HOVERGENHBG062091.

Family and domain databases

InterProIPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEPS00629. IMP_1. False negative.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIMPA3_XENTR
AccessionPrimary (citable) accession number: Q28CL4
Secondary accession number(s): Q0VGW1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: October 19, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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