Q28CL4 (IMPA3_XENTR) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Inositol monophosphatase 3 Short name=IMP 3 Short name=IMPase 3 EC=3.1.3.25 Alternative name(s): Inositol monophosphatase domain-containing protein 1 Inositol-1(or 4)-monophosphatase 3 Myo-inositol monophosphatase A3 | ||||||
| Gene names |
| ||||||
| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | ||||||
| Taxonomic identifier | 8364 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Protein attributes
| Sequence length | 356 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | Myo-inositol phosphate + H2O = myo-inositol + phosphate. |
| Cofactor | Magnesium By similarity. |
| Pathway | Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the inositol monophosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | inositol monophosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 356 | 356 | Inositol monophosphatase 3 | PRO_0000289045 | |||||
Regions | |||||||||
| Transmembrane | 11 – 31 | 21 | Helical; Potential | ||||||
| Region | 169 – 172 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 127 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 167 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 167 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 169 | 1 | Magnesium 1; via carbonyl oxygen By similarity | ||||||
| Metal binding | 170 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 293 | 1 | Magnesium 2 By similarity | ||||||
| Binding site | 127 | 1 | Substrate By similarity | ||||||
| Binding site | 293 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 344 | 1 | S → A in AAH80464. Ref.2 | ||||||
Sequences
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References
| [1] | Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg. |
| [2] | NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR926321 mRNA. Translation: CAJ82287.1. BC080464 mRNA. Translation: AAH80464.1. |
| RefSeq | NP_001016215.2. NM_001016215.3. |
| UniGene | Str.7052. |
3D structure databases | |
| ProteinModelPortal | Q28CL4. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 548969. |
| KEGG | xtr:548969. |
Organism-specific databases | |
| CTD | 54928. |
| Xenbase | XB-GENE-5751033. impad1. |
Phylogenomic databases | |
| eggNOG | veNOG09613. |
| GeneTree | ENSGT00530000063462. |
| HOVERGEN | HBG062091. |
Family and domain databases | |
| InterPro | IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view] |
| PANTHER | PTHR20854. Inositol_P. 1 hit. |
| Pfam | PF00459. Inositol_P. 1 hit. [Graphical view] |
| PROSITE | PS00629. IMP_1. False negative. PS00630. IMP_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IMPA3_XENTR | ||||||||
| Accession | Primary (citable) accession number: Q28CL4 Secondary accession number(s): Q0VGW1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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