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Protein

Nuclear receptor subfamily 2 group C member 1

Gene

nr2c1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 22476Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 17221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 20720NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-XTR-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group C member 1
Alternative name(s):
Developmental orphan receptor 2
Short name:
DOR2
Orphan nuclear receptor TR2
Testicular receptor 2
Gene namesi
Name:nr2c1Imported
Synonyms:dor2By similarity
ORF Names:TEgg078f23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-484727. nr2c1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Nuclear receptor subfamily 2 group C member 1PRO_0000287914Add
BLAST

Proteomic databases

PaxDbiQ28CK1.

Expressioni

Gene expression databases

BgeeiQ28CK1.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051399.

Structurei

3D structure databases

ProteinModelPortaliQ28CK1.
SMRiQ28CK1. Positions 151-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR2 subfamily.Sequence analysis
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 20720NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000013058.
HOVERGENiHBG008596.
InParanoidiQ28CK1.
KOiK08543.

Family and domain databases

Gene3Di1.10.565.10. 3 hits.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28CK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIEEIAHQ IIEQQMGEIS RSQPEISQTA LMDGTTQRIQ LVPSESSVSV
60 70 80 90 100
PQRIQIVTDP QTGQKIQIVT ALDQSGASKQ FILTNNDGSL PSKVILTRQD
110 120 130 140 150
SSQGKVYLTT PDAAGVNQLF ISTPDVPAQH IQILSDTQCL DQNLNKQLVE
160 170 180 190 200
LCVVCGDKAS GRHYGAVTCE GCKGFFKRSI RKNLVYTCRG SKDCVINKHY
210 220 230 240 250
RNRCQYCRLQ RCIALGMKQD SVQCERKPIE VSREKSSNCA ASTEKIYIRK
260 270 280 290 300
DLRSPLAATT TFVTENKTSR TTSLLDSGML VNIQQSGVKN ESILITPNKV
310 320 330 340 350
DACQGDLSTL ANVVTSLANL NKSKELPQTN TELSIIESLS NGDSSLSELA
360 370 380 390 400
QDDQSNSEVT RAFDTLAKAL NQSENSAQGS SECVGSNSNL TDANVEIEGP
410 420 430 440 450
LLSDAHIAFR LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPSFQSL
460 470 480 490 500
GQENSISLVK ACWNELFSLG LAQCCQVMNV ETILAAFVNH LHNSMQHDKL
510 520 530 540 550
SADKVKLVMD HIFKLQEFCN SMVKLSVDGY EYAYLKAIAL FSPDHPGLEN
560 570 580 590 600
VSHIEKLQEK AYMEFQDYVT KTYPEDTYRL SRLLLRLPAL RLLNAAITEE
610 620 630
LFFAGLIGNV QIDSIIPYIL RMETSDYNSQ IIGLTV
Length:636
Mass (Da):70,465
Last modified:April 4, 2006 - v1
Checksum:iBB7EAB09854ED54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926338 mRNA. Translation: CAJ83740.1.
BC123034 mRNA. Translation: AAI23035.1.
RefSeqiNP_001016207.1. NM_001016207.2.
XP_012814450.1. XM_012958996.1.
XP_012814451.1. XM_012958997.1.
UniGeneiStr.15706.

Genome annotation databases

GeneIDi548961.
KEGGixtr:548961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926338 mRNA. Translation: CAJ83740.1.
BC123034 mRNA. Translation: AAI23035.1.
RefSeqiNP_001016207.1. NM_001016207.2.
XP_012814450.1. XM_012958996.1.
XP_012814451.1. XM_012958997.1.
UniGeneiStr.15706.

3D structure databases

ProteinModelPortaliQ28CK1.
SMRiQ28CK1. Positions 151-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051399.

Proteomic databases

PaxDbiQ28CK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi548961.
KEGGixtr:548961.

Organism-specific databases

CTDi7181.
XenbaseiXB-GENE-484727. nr2c1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000013058.
HOVERGENiHBG008596.
InParanoidiQ28CK1.
KOiK08543.

Enzyme and pathway databases

ReactomeiR-XTR-383280. Nuclear Receptor transcription pathway.

Gene expression databases

BgeeiQ28CK1.

Family and domain databases

Gene3Di1.10.565.10. 3 hits.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EggImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6Imported.
    Tissue: OviductImported.

Entry informationi

Entry nameiNR2C1_XENTR
AccessioniPrimary (citable) accession number: Q28CK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 4, 2006
Last modified: February 17, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.