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Protein

Nuclear receptor subfamily 2 group C member 1

Gene

nr2c1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi149 – 224Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri152 – 172NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri188 – 207NR C4-typePROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group C member 1
Alternative name(s):
Developmental orphan receptor 2
Short name:
DOR2
Orphan nuclear receptor TR2
Testicular receptor 2
Gene namesi
Name:nr2c1Imported
Synonyms:dor2By similarity
ORF Names:TEgg078f23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-484727 nr2c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002879141 – 636Nuclear receptor subfamily 2 group C member 1Add BLAST636

Proteomic databases

PaxDbiQ28CK1

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051399

Structurei

3D structure databases

ProteinModelPortaliQ28CK1
SMRiQ28CK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini382 – 623NR LBDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR2 subfamily.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 172NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri188 – 207NR C4-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000013058
HOVERGENiHBG008596
InParanoidiQ28CK1
KOiK08543
OrthoDBiEOG091G099H

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q28CK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIEEIAHQ IIEQQMGEIS RSQPEISQTA LMDGTTQRIQ LVPSESSVSV
60 70 80 90 100
PQRIQIVTDP QTGQKIQIVT ALDQSGASKQ FILTNNDGSL PSKVILTRQD
110 120 130 140 150
SSQGKVYLTT PDAAGVNQLF ISTPDVPAQH IQILSDTQCL DQNLNKQLVE
160 170 180 190 200
LCVVCGDKAS GRHYGAVTCE GCKGFFKRSI RKNLVYTCRG SKDCVINKHY
210 220 230 240 250
RNRCQYCRLQ RCIALGMKQD SVQCERKPIE VSREKSSNCA ASTEKIYIRK
260 270 280 290 300
DLRSPLAATT TFVTENKTSR TTSLLDSGML VNIQQSGVKN ESILITPNKV
310 320 330 340 350
DACQGDLSTL ANVVTSLANL NKSKELPQTN TELSIIESLS NGDSSLSELA
360 370 380 390 400
QDDQSNSEVT RAFDTLAKAL NQSENSAQGS SECVGSNSNL TDANVEIEGP
410 420 430 440 450
LLSDAHIAFR LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPSFQSL
460 470 480 490 500
GQENSISLVK ACWNELFSLG LAQCCQVMNV ETILAAFVNH LHNSMQHDKL
510 520 530 540 550
SADKVKLVMD HIFKLQEFCN SMVKLSVDGY EYAYLKAIAL FSPDHPGLEN
560 570 580 590 600
VSHIEKLQEK AYMEFQDYVT KTYPEDTYRL SRLLLRLPAL RLLNAAITEE
610 620 630
LFFAGLIGNV QIDSIIPYIL RMETSDYNSQ IIGLTV
Length:636
Mass (Da):70,465
Last modified:April 4, 2006 - v1
Checksum:iBB7EAB09854ED54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926338 mRNA Translation: CAJ83740.1
BC123034 mRNA Translation: AAI23035.1
RefSeqiNP_001016207.1, NM_001016207.2
XP_012814450.1, XM_012958996.2
XP_012814451.1, XM_012958997.2
UniGeneiStr.15706

Genome annotation databases

GeneIDi548961
KEGGixtr:548961

Similar proteinsi

Entry informationi

Entry nameiNR2C1_XENTR
AccessioniPrimary (citable) accession number: Q28CK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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