Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q28C98 (MESH1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

EC=3.1.7.2
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name=MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name=(ppGpp)ase
Gene names
Name:hddc3
Synonyms:Mesh1
ORF Names:TGas061b07.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ppGpp hydrolyzing enzyme involved in starvation response By similarity.

Catalytic activity

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactor

Manganese By similarity.

Sequence similarities

Belongs to the MESH1 family.

Contains 1 HD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
PRO_0000263113

Regions

Domain32 – 12796HD

Sites

Active site651Nucleophile By similarity
Active site661Nucleophile By similarity
Metal binding351Manganese By similarity
Metal binding611Manganese By similarity
Metal binding621Manganese By similarity
Metal binding1221Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28C98 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: C0667B09D727D7E2

FASTA17920,390
        10         20         30         40         50         60 
MSSDAALILE AANFAAEKHK QQRRKDPEKT PYINHPLGVA RILSHEGGIT DTAVLQAALL 

        70         80         90        100        110        120 
HDTVEDTNTT FEEIELHFGQ DVRNIVEEVT DDKTLPKMER KRLQMEHAPH CSQKAKLVKL 

       130        140        150        160        170 
ADKLYNLRDL KRCTPEGWSE QRVQEYFQWA SEVVKGLRGT NSILEGKLDH MFMDQGIAV 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR942384 mRNA. Translation: CAJ81555.1.
RefSeqNP_001039099.1. NM_001045634.1.
UniGeneStr.24610.

3D structure databases

ProteinModelPortalQ28C98.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID733918.
KEGGxtr:733918.

Organism-specific databases

CTD374659.
XenbaseXB-GENE-973216. hddc3.

Phylogenomic databases

eggNOGCOG0317.
HOVERGENHBG081594.
KOK01139.

Gene expression databases

BgeeQ28C98.

Family and domain databases

Gene3D1.10.3210.10. 2 hits.
InterProIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
SMARTSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMESH1_XENTR
AccessionPrimary (citable) accession number: Q28C98
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families