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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35ManganeseBy similarity1
Metal bindingi61ManganeseBy similarity1
Metal bindingi62ManganeseBy similarity1
Active sitei65NucleophileBy similarity1
Active sitei66NucleophileBy similarity1
Metal bindingi122ManganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:TGas061b07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-973216. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002631131 – 179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1Add BLAST179

Proteomic databases

PaxDbiQ28C98.

Expressioni

Gene expression databases

BgeeiENSXETG00000009763.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000021510.

Structurei

3D structure databases

ProteinModelPortaliQ28C98.
SMRiQ28C98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 127HDPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the MESH1 family.Curated

Phylogenomic databases

eggNOGiKOG1157. Eukaryota.
COG0317. LUCA.
HOVERGENiHBG081594.
InParanoidiQ28C98.
KOiK21138.
OrthoDBiEOG091G0L17.

Family and domain databases

InterProiView protein in InterPro
IPR003607. HD/PDEase_dom.
PfamiView protein in Pfam
PF13328. HD_4. 1 hit.
SMARTiView protein in SMART
SM00471. HDc. 1 hit.
PROSITEiView protein in PROSITE
PS51831. HD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28C98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDAALILE AANFAAEKHK QQRRKDPEKT PYINHPLGVA RILSHEGGIT
60 70 80 90 100
DTAVLQAALL HDTVEDTNTT FEEIELHFGQ DVRNIVEEVT DDKTLPKMER
110 120 130 140 150
KRLQMEHAPH CSQKAKLVKL ADKLYNLRDL KRCTPEGWSE QRVQEYFQWA
160 170
SEVVKGLRGT NSILEGKLDH MFMDQGIAV
Length:179
Mass (Da):20,390
Last modified:April 4, 2006 - v1
Checksum:iC0667B09D727D7E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942384 mRNA. Translation: CAJ81555.1.
RefSeqiNP_001039099.1. NM_001045634.1.
UniGeneiStr.24610.

Genome annotation databases

GeneIDi733918.
KEGGixtr:733918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942384 mRNA. Translation: CAJ81555.1.
RefSeqiNP_001039099.1. NM_001045634.1.
UniGeneiStr.24610.

3D structure databases

ProteinModelPortaliQ28C98.
SMRiQ28C98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000021510.

Proteomic databases

PaxDbiQ28C98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi733918.
KEGGixtr:733918.

Organism-specific databases

CTDi374659.
XenbaseiXB-GENE-973216. hddc3.

Phylogenomic databases

eggNOGiKOG1157. Eukaryota.
COG0317. LUCA.
HOVERGENiHBG081594.
InParanoidiQ28C98.
KOiK21138.
OrthoDBiEOG091G0L17.

Gene expression databases

BgeeiENSXETG00000009763.

Family and domain databases

InterProiView protein in InterPro
IPR003607. HD/PDEase_dom.
PfamiView protein in Pfam
PF13328. HD_4. 1 hit.
SMARTiView protein in SMART
SM00471. HDc. 1 hit.
PROSITEiView protein in PROSITE
PS51831. HD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMESH1_XENTR
AccessioniPrimary (citable) accession number: Q28C98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 4, 2006
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.