Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q28C98

- MESH1_XENTR

UniProt

Q28C98 - MESH1_XENTR

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    ppGpp hydrolyzing enzyme involved in starvation response.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi35 – 351ManganeseBy similarity
    Metal bindingi61 – 611ManganeseBy similarity
    Metal bindingi62 – 621ManganeseBy similarity
    Active sitei65 – 651NucleophileBy similarity
    Active sitei66 – 661NucleophileBy similarity
    Metal bindingi122 – 1221ManganeseBy similarity

    GO - Molecular functioni

    1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoric diester hydrolase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
    Alternative name(s):
    HD domain-containing protein 3
    Metazoan SpoT homolog 1
    Short name:
    MESH1
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:hddc3
    Synonyms:Mesh1
    ORF Names:TGas061b07.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-973216. hddc3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263113Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ28C98.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28C98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 12796HDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MESH1 family.Curated
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    HOVERGENiHBG081594.
    KOiK01139.

    Family and domain databases

    Gene3Di1.10.3210.10. 2 hits.
    InterProiIPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28C98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDAALILE AANFAAEKHK QQRRKDPEKT PYINHPLGVA RILSHEGGIT    50
    DTAVLQAALL HDTVEDTNTT FEEIELHFGQ DVRNIVEEVT DDKTLPKMER 100
    KRLQMEHAPH CSQKAKLVKL ADKLYNLRDL KRCTPEGWSE QRVQEYFQWA 150
    SEVVKGLRGT NSILEGKLDH MFMDQGIAV 179
    Length:179
    Mass (Da):20,390
    Last modified:April 4, 2006 - v1
    Checksum:iC0667B09D727D7E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR942384 mRNA. Translation: CAJ81555.1.
    RefSeqiNP_001039099.1. NM_001045634.1.
    UniGeneiStr.24610.

    Genome annotation databases

    GeneIDi733918.
    KEGGixtr:733918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR942384 mRNA. Translation: CAJ81555.1 .
    RefSeqi NP_001039099.1. NM_001045634.1.
    UniGenei Str.24610.

    3D structure databases

    ProteinModelPortali Q28C98.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 733918.
    KEGGi xtr:733918.

    Organism-specific databases

    CTDi 374659.
    Xenbasei XB-GENE-973216. hddc3.

    Phylogenomic databases

    eggNOGi COG0317.
    HOVERGENi HBG081594.
    KOi K01139.

    Gene expression databases

    Bgeei Q28C98.

    Family and domain databases

    Gene3Di 1.10.3210.10. 2 hits.
    InterProi IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula.

    Entry informationi

    Entry nameiMESH1_XENTR
    AccessioniPrimary (citable) accession number: Q28C98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3