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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351ManganeseBy similarity
Metal bindingi61 – 611ManganeseBy similarity
Metal bindingi62 – 621ManganeseBy similarity
Active sitei65 – 651NucleophileBy similarity
Active sitei66 – 661NucleophileBy similarity
Metal bindingi122 – 1221ManganeseBy similarity

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:TGas061b07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-973216. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263113Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28C98.
ExpressionAtlasiQ28C98. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ28C98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12796HDAdd
BLAST

Sequence similaritiesi

Belongs to the MESH1 family.Curated
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
InParanoidiQ28C98.
KOiK01139.

Family and domain databases

Gene3Di1.10.3210.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28C98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDAALILE AANFAAEKHK QQRRKDPEKT PYINHPLGVA RILSHEGGIT
60 70 80 90 100
DTAVLQAALL HDTVEDTNTT FEEIELHFGQ DVRNIVEEVT DDKTLPKMER
110 120 130 140 150
KRLQMEHAPH CSQKAKLVKL ADKLYNLRDL KRCTPEGWSE QRVQEYFQWA
160 170
SEVVKGLRGT NSILEGKLDH MFMDQGIAV
Length:179
Mass (Da):20,390
Last modified:April 3, 2006 - v1
Checksum:iC0667B09D727D7E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942384 mRNA. Translation: CAJ81555.1.
RefSeqiNP_001039099.1. NM_001045634.1.
UniGeneiStr.24610.

Genome annotation databases

GeneIDi733918.
KEGGixtr:733918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942384 mRNA. Translation: CAJ81555.1.
RefSeqiNP_001039099.1. NM_001045634.1.
UniGeneiStr.24610.

3D structure databases

ProteinModelPortaliQ28C98.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi733918.
KEGGixtr:733918.

Organism-specific databases

CTDi374659.
XenbaseiXB-GENE-973216. hddc3.

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
InParanoidiQ28C98.
KOiK01139.

Gene expression databases

BgeeiQ28C98.
ExpressionAtlasiQ28C98. baseline.

Family and domain databases

Gene3Di1.10.3210.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.

Entry informationi

Entry nameiMESH1_XENTR
AccessioniPrimary (citable) accession number: Q28C98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 11, 2006
Last sequence update: April 3, 2006
Last modified: January 6, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.