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Q28C98

- MESH1_XENTR

UniProt

Q28C98 - MESH1_XENTR

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Protein
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Gene
hddc3, Mesh1, TGas061b07.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351Manganese By similarity
Metal bindingi61 – 611Manganese By similarity
Metal bindingi62 – 621Manganese By similarity
Active sitei65 – 651Nucleophile By similarity
Active sitei66 – 661Nucleophile By similarity
Metal bindingi122 – 1221Manganese By similarity

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. phosphoric diester hydrolase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:TGas061b07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-973216. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
PRO_0000263113Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28C98.

Structurei

3D structure databases

ProteinModelPortaliQ28C98.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12796HD
Add
BLAST

Sequence similaritiesi

Belongs to the MESH1 family.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
KOiK01139.

Family and domain databases

Gene3Di1.10.3210.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28C98-1 [UniParc]FASTAAdd to Basket

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MSSDAALILE AANFAAEKHK QQRRKDPEKT PYINHPLGVA RILSHEGGIT    50
DTAVLQAALL HDTVEDTNTT FEEIELHFGQ DVRNIVEEVT DDKTLPKMER 100
KRLQMEHAPH CSQKAKLVKL ADKLYNLRDL KRCTPEGWSE QRVQEYFQWA 150
SEVVKGLRGT NSILEGKLDH MFMDQGIAV 179
Length:179
Mass (Da):20,390
Last modified:April 4, 2006 - v1
Checksum:iC0667B09D727D7E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR942384 mRNA. Translation: CAJ81555.1.
RefSeqiNP_001039099.1. NM_001045634.1.
UniGeneiStr.24610.

Genome annotation databases

GeneIDi733918.
KEGGixtr:733918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR942384 mRNA. Translation: CAJ81555.1 .
RefSeqi NP_001039099.1. NM_001045634.1.
UniGenei Str.24610.

3D structure databases

ProteinModelPortali Q28C98.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 733918.
KEGGi xtr:733918.

Organism-specific databases

CTDi 374659.
Xenbasei XB-GENE-973216. hddc3.

Phylogenomic databases

eggNOGi COG0317.
HOVERGENi HBG081594.
KOi K01139.

Gene expression databases

Bgeei Q28C98.

Family and domain databases

Gene3Di 1.10.3210.10. 2 hits.
InterProi IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.

Entry informationi

Entry nameiMESH1_XENTR
AccessioniPrimary (citable) accession number: Q28C98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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