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Q28C91

- ECHD1_XENTR

UniProt

Q28C91 - ECHD1_XENTR

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Protein
Ethylmalonyl-CoA decarboxylase
Gene
echdc1, TGas092k23.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:echdc1
ORF Names:TGas092k23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-958554. echdc1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Ethylmalonyl-CoA decarboxylase
PRO_0000416274Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28C91.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000023285.

Structurei

3D structure databases

ProteinModelPortaliQ28C91.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
TreeFamiTF315986.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28C91-1 [UniParc]FASTAAdd to Basket

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MGIFVCRNSL RMLNVRWLYH RCLSLYNSNH GFNEAKIKEK LAQFTGGSVD    50
LSKMDNGIAE ICINNPSRMN AFTGTMMIEL EERISDLENW KNGKGLIVYG 100
AENTFCSGSD LNAVKAISNP QEGMMMCMLM QNTLTRLQRL PLISVALIQG 150
KALGGGAELC TACDFRLMTE GSEIRFVHKQ MGLVPGWGGA ARLIHLIGSR 200
HALKLLSGAL RVHPENALEL GLADNILLGT EDGFLSEAEN WIMPYIKGPS 250
DVSRAVKKVI ISGREQKLED ALRTEKEIFG TVWGGLANLQ ALAKGTKHK 299
Length:299
Mass (Da):32,907
Last modified:April 4, 2006 - v1
Checksum:iA0452C4A22C4DDF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR942395 mRNA. Translation: CAJ83594.1.
AAMC01103784 Genomic DNA. No translation available.
BC088780 mRNA. Translation: AAH88780.1.
BC118874 mRNA. Translation: AAI18875.1.
BC170562 mRNA. Translation: AAI70562.1.
BC170919 mRNA. Translation: AAI70919.1.
RefSeqiNP_001037862.1. NM_001044397.1.
UniGeneiStr.43472.

Genome annotation databases

EnsembliENSXETT00000064480; ENSXETP00000061979; ENSXETG00000010628.
GeneIDi496886.
KEGGixtr:496886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR942395 mRNA. Translation: CAJ83594.1 .
AAMC01103784 Genomic DNA. No translation available.
BC088780 mRNA. Translation: AAH88780.1 .
BC118874 mRNA. Translation: AAI18875.1 .
BC170562 mRNA. Translation: AAI70562.1 .
BC170919 mRNA. Translation: AAI70919.1 .
RefSeqi NP_001037862.1. NM_001044397.1.
UniGenei Str.43472.

3D structure databases

ProteinModelPortali Q28C91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000023285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000064480 ; ENSXETP00000061979 ; ENSXETG00000010628 .
GeneIDi 496886.
KEGGi xtr:496886.

Organism-specific databases

CTDi 55862.
Xenbasei XB-GENE-958554. echdc1.

Phylogenomic databases

GeneTreei ENSGT00720000108837.
HOGENOMi HOG000007808.
HOVERGENi HBG054783.
OMAi HKHMGLV.
OrthoDBi EOG79W95T.
TreeFami TF315986.

Gene expression databases

Bgeei Q28C91.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Gastrula and Ovary.

Entry informationi

Entry nameiECHD1_XENTR
AccessioniPrimary (citable) accession number: Q28C91
Secondary accession number(s): F6UNG1, Q0VFD0, Q5M791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 4, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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