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Protein

Ethylmalonyl-CoA decarboxylase

Gene

echdc1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:echdc1
ORF Names:TGas092k23.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-958554. echdc1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Ethylmalonyl-CoA decarboxylasePRO_0000416274Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28C91.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000023285.

Structurei

3D structure databases

ProteinModelPortaliQ28C91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
InParanoidiQ28C91.
KOiK18426.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
TreeFamiTF315986.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28C91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIFVCRNSL RMLNVRWLYH RCLSLYNSNH GFNEAKIKEK LAQFTGGSVD
60 70 80 90 100
LSKMDNGIAE ICINNPSRMN AFTGTMMIEL EERISDLENW KNGKGLIVYG
110 120 130 140 150
AENTFCSGSD LNAVKAISNP QEGMMMCMLM QNTLTRLQRL PLISVALIQG
160 170 180 190 200
KALGGGAELC TACDFRLMTE GSEIRFVHKQ MGLVPGWGGA ARLIHLIGSR
210 220 230 240 250
HALKLLSGAL RVHPENALEL GLADNILLGT EDGFLSEAEN WIMPYIKGPS
260 270 280 290
DVSRAVKKVI ISGREQKLED ALRTEKEIFG TVWGGLANLQ ALAKGTKHK
Length:299
Mass (Da):32,907
Last modified:April 4, 2006 - v1
Checksum:iA0452C4A22C4DDF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942395 mRNA. Translation: CAJ83594.1.
AAMC01103784 Genomic DNA. No translation available.
BC088780 mRNA. Translation: AAH88780.1.
BC118874 mRNA. Translation: AAI18875.1.
BC170562 mRNA. Translation: AAI70562.1.
BC170919 mRNA. Translation: AAI70919.1.
RefSeqiNP_001037862.1. NM_001044397.1.
UniGeneiStr.43472.

Genome annotation databases

EnsembliENSXETT00000064480; ENSXETP00000061979; ENSXETG00000010628.
GeneIDi496886.
KEGGixtr:496886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942395 mRNA. Translation: CAJ83594.1.
AAMC01103784 Genomic DNA. No translation available.
BC088780 mRNA. Translation: AAH88780.1.
BC118874 mRNA. Translation: AAI18875.1.
BC170562 mRNA. Translation: AAI70562.1.
BC170919 mRNA. Translation: AAI70919.1.
RefSeqiNP_001037862.1. NM_001044397.1.
UniGeneiStr.43472.

3D structure databases

ProteinModelPortaliQ28C91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000023285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000064480; ENSXETP00000061979; ENSXETG00000010628.
GeneIDi496886.
KEGGixtr:496886.

Organism-specific databases

CTDi55862.
XenbaseiXB-GENE-958554. echdc1.

Phylogenomic databases

GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
InParanoidiQ28C91.
KOiK18426.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
TreeFamiTF315986.

Gene expression databases

BgeeiQ28C91.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Gastrula and Ovary.

Entry informationi

Entry nameiECHD1_XENTR
AccessioniPrimary (citable) accession number: Q28C91
Secondary accession number(s): F6UNG1, Q0VFD0, Q5M791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 4, 2006
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.