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Q28C91

- ECHD1_XENTR

UniProt

Q28C91 - ECHD1_XENTR

Protein

Ethylmalonyl-CoA decarboxylase

Gene

echdc1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.By similarity

    Catalytic activityi

    (S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
    (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

    GO - Molecular functioni

    1. carboxy-lyase activity Source: UniProtKB
    2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
    Alternative name(s):
    Enoyl-CoA hydratase domain-containing protein 1
    Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
    Short name:
    MMCD
    Gene namesi
    Name:echdc1
    ORF Names:TGas092k23.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-958554. echdc1.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Ethylmalonyl-CoA decarboxylasePRO_0000416274Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ28C91.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000023285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28C91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00720000108837.
    HOGENOMiHOG000007808.
    HOVERGENiHBG054783.
    OMAiHKHMGLV.
    OrthoDBiEOG79W95T.
    TreeFamiTF315986.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28C91-1 [UniParc]FASTAAdd to Basket

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    MGIFVCRNSL RMLNVRWLYH RCLSLYNSNH GFNEAKIKEK LAQFTGGSVD    50
    LSKMDNGIAE ICINNPSRMN AFTGTMMIEL EERISDLENW KNGKGLIVYG 100
    AENTFCSGSD LNAVKAISNP QEGMMMCMLM QNTLTRLQRL PLISVALIQG 150
    KALGGGAELC TACDFRLMTE GSEIRFVHKQ MGLVPGWGGA ARLIHLIGSR 200
    HALKLLSGAL RVHPENALEL GLADNILLGT EDGFLSEAEN WIMPYIKGPS 250
    DVSRAVKKVI ISGREQKLED ALRTEKEIFG TVWGGLANLQ ALAKGTKHK 299
    Length:299
    Mass (Da):32,907
    Last modified:April 4, 2006 - v1
    Checksum:iA0452C4A22C4DDF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR942395 mRNA. Translation: CAJ83594.1.
    AAMC01103784 Genomic DNA. No translation available.
    BC088780 mRNA. Translation: AAH88780.1.
    BC118874 mRNA. Translation: AAI18875.1.
    BC170562 mRNA. Translation: AAI70562.1.
    BC170919 mRNA. Translation: AAI70919.1.
    RefSeqiNP_001037862.1. NM_001044397.1.
    UniGeneiStr.43472.

    Genome annotation databases

    EnsembliENSXETT00000064480; ENSXETP00000061979; ENSXETG00000010628.
    GeneIDi496886.
    KEGGixtr:496886.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR942395 mRNA. Translation: CAJ83594.1 .
    AAMC01103784 Genomic DNA. No translation available.
    BC088780 mRNA. Translation: AAH88780.1 .
    BC118874 mRNA. Translation: AAI18875.1 .
    BC170562 mRNA. Translation: AAI70562.1 .
    BC170919 mRNA. Translation: AAI70919.1 .
    RefSeqi NP_001037862.1. NM_001044397.1.
    UniGenei Str.43472.

    3D structure databases

    ProteinModelPortali Q28C91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000023285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000064480 ; ENSXETP00000061979 ; ENSXETG00000010628 .
    GeneIDi 496886.
    KEGGi xtr:496886.

    Organism-specific databases

    CTDi 55862.
    Xenbasei XB-GENE-958554. echdc1.

    Phylogenomic databases

    GeneTreei ENSGT00720000108837.
    HOGENOMi HOG000007808.
    HOVERGENi HBG054783.
    OMAi HKHMGLV.
    OrthoDBi EOG79W95T.
    TreeFami TF315986.

    Gene expression databases

    Bgeei Q28C91.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: N6.
      Tissue: Gastrula and Ovary.

    Entry informationi

    Entry nameiECHD1_XENTR
    AccessioniPrimary (citable) accession number: Q28C91
    Secondary accession number(s): F6UNG1, Q0VFD0, Q5M791
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3