Reviewed, UniProtKB/Swiss-Prot Q28C88 (MOGT1_XENTR)

Names and origin

Protein names

Recommended name:
    2-acylglycerol O-acyltransferase 1
    EC=2.3.1.22
Alternative name(s):
    Monoacylglycerol O-acyltransferase 1
    Acyl CoA:monoacylglycerol acyltransferase 1
      Short name=MGAT1

Gene names

Name:	mogat1
ORF Names:	TGas062a14.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	2-acylglycerol O-acyltransferase 1		PRO_0000249061
Regions
	Transmembrane	24 – 44	21	Potential
	Transmembrane	47 – 67	21	Potential
Amino acid modifications
	Glycosylation	77	1	N-linked (GlcNAc...) Potential
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28C88-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: EAD7AB1E259E6690	FASTA	335	38,751
	10 20 30 40 50 60 MKLEFAPINI PLARRLQTTA VFQWVFSFLL LAQCCIGIFL SLVLARLWLI LALYVLWLYL 70 80 90 100 110 120 DWETPQAGGR RWEWVRNWTV WKYFKDYFPI RLVKTCDLDP QHNYIMGFHP HGVLVAGAFG 130 140 150 160 170 180 NFCTNYTGFK ELFPGLTPYL HILPFWFRCP FFREYAMCVG LVSATKKSVN HVLSKENGGN 190 200 210 220 230 240 ISIIVIGGAE ESLDAHPGSL ILHILKRKGF IKVAFKQGAH LVPVFSFGEN ELFQQVPNPK 250 260 270 280 290 300 GSFLRCVQER LQKIMGFAMP LFHARGIFQY SFGLMPYRMP IHTVVGRPIP VKQTSHPTQE 310 320 330 EIESLHQQYL SALRDLFEEH KERYGIPEHE SLIFT

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastrula.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR942398 mRNA. Translation: CAJ83751.1.
RefSeq	NP_001039202.1.
UniGene	Str.5618
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	734060.
KEGG	xtr:734060.
Organism-specific databases
Xenbase	XB-FEAT-1004225.
Phylogenomic databases
HOVERGEN	Q28C88.
Enzyme and pathway databases
BRENDA	2.3.1.22. 279072.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOGT1_XENTR

Accession

Primary (citable) accession number: Q28C88

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	April 4, 2006
Last modified:	October 13, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project