Q28C85 (Q28C85_XENTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase RuleBase RU003903
EC=1.5.1.2 RuleBase RU003903

Gene names

Name:	pycr1 Xenbase XB-FEAT-1016045 Xenbase XB-FEAT-1016046 Ensembl ENSXETP00000011845 Xenbase XB-GENE-1016046
Synonyms:	pycr2 Xenbase XB-FEAT-1016045 EMBL CAJ82542.1
ORF Names:	TEgg044f21.1-001 EMBL CAJ81362.1, TGas136k01.1-001 EMBL CAJ82542.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) EMBL CAJ82542.1

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H. RuleBase RU003903
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. RuleBase RU003903
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family. RuleBase RU003903

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis RuleBase RU003903
Ligand	NADP RuleBase RU003903
Molecular function	Oxidoreductase RuleBase RU003903
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q28C85 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 3D5A17AB570FDF6E	FASTA	320	33,722
	10 20 30 40 50 60 MSVGFIGAGQ LTYALVRGFT VAGVLAAHKI TASSPDTDLP TVAGLRKLGI NFTTSNKDTV 70 80 90 100 110 120 KSSDVLFLAV KPPIIPFVLD EIGSDIEDRH VVVSCAAGVT ISSIEKKLGS FHPSPKVIRC 130 140 150 160 170 180 MTNTPVVVRE GATVYATGTH ADVEDGRLLE QLMQSVGFCT EVEEDLIDAV TGLSGSGPAY 190 200 210 220 230 240 SFTALDALAD GGVKMGLPRR LAVRLGAQAM LGAAKMLLES EQHPGQLKDN VCSPGGATIH 250 260 270 280 290 300 ALHFLESGGF RSLLINAVEA SCIRTRELQY LADQEKIPAA AIKKTTLSKV QQESPSISTA 310 320 PQGSKVSLFN NKYPAGVKKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the Western clawed frog Xenopus tropicalis." Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., Gerhard D.S. , Goodstein D., Graves T., Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., Rokhsar D.S. Science 328:633-636(2010) [PubMed: 20431018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION.
[3]	Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K., Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V., McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J., Zorn A.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAMC01069107 Genomic DNA. No translation available. CR848490 mRNA. Translation: CAJ81362.1. CR942403 mRNA. Translation: CAJ82542.1.
RefSeq	NP_001015942.1. NM_001015942.2.
UniGene	Str.43940.
3D structure databases
ProteinModelPortal	Q28C85.
SMR	Q28C85. Positions 1-275.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28C85.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000011845; ENSXETP00000011845; ENSXETG00000005381.
GeneID	548696.
KEGG	xtr:548696.
Organism-specific databases
CTD	5831.
Xenbase	XB-GENE-1016046. pycr1.
Phylogenomic databases
GeneTree	ENSGT00390000007443.
HOVERGEN	HBG053399.
OMA	RTFNEHQ.
OrthoDB	EOG4PZJ76.
PhylomeDB	Q28C85.
Gene expression databases
Bgee	Q28C85.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q28C85_XENTR

Accession

Primary (citable) accession number: Q28C85

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)