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Protein

Calumenin

Gene

calu

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi81 – 92121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi117 – 128122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi164 – 175123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi201 – 212124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi242 – 253125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi278 – 289126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Gene namesi
Name:calu
ORF Names:TNeu055n17.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1007422. calu.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity
  • Golgi apparatus By similarity
  • Secreted By similarity
  • Melanosome By similarity
  • Sarcoplasmic reticulum lumen By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 315296CalumeninPRO_0000364198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ28BT4.
PRIDEiQ28BT4.

Expressioni

Gene expression databases

BgeeiQ28BT4.

Interactioni

Subunit structurei

Interacts with ggcx.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049856.

Structurei

3D structure databases

ProteinModelPortaliQ28BT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 10336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini104 – 13936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 18636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini188 – 22336EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini229 – 26436EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 30036EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi312 – 3154Prevents secretion from ERBy similarity

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ28BT4.
OMAiNNDVDRT.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28BT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRRLLLCL CLWVACVVSK PTEKKDRVHH DPQLSEKVHD DAQNFDYDHD
60 70 80 90 100
AFLGAEEAKT FDQLTPEESK ERLGMIVSKI DLDNDGYVTE GELTAWIKKA
110 120 130 140 150
QKKYVYDNVE RQWQEFDLNQ DGLVSWDEYR NVTYGTYLDD PDPDNSFNYK
160 170 180 190 200
QMMVRDERRF KMADQDGDLI ATKEEFTAFL HPEEFDYMKD IVVLETMEDI
210 220 230 240 250
DKNGDGLIDL EEYIGDMYNH DGDANEPEWV KTEREQFVEF RDKNHDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAES RHLVYESDQN KDSKLTREEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Length:315
Mass (Da):37,156
Last modified:April 4, 2006 - v1
Checksum:iC5A4A29AB05091EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942649 mRNA. Translation: CAJ82342.1.
RefSeqiXP_012814244.1. XM_012958790.1.
UniGeneiStr.11110.

Genome annotation databases

GeneIDi407965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942649 mRNA. Translation: CAJ82342.1.
RefSeqiXP_012814244.1. XM_012958790.1.
UniGeneiStr.11110.

3D structure databases

ProteinModelPortaliQ28BT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049856.

Proteomic databases

PaxDbiQ28BT4.
PRIDEiQ28BT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi407965.

Organism-specific databases

CTDi813.
XenbaseiXB-GENE-1007422. calu.

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ28BT4.
OMAiNNDVDRT.

Gene expression databases

BgeeiQ28BT4.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.

Entry informationi

Entry nameiCALU_XENTR
AccessioniPrimary (citable) accession number: Q28BT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 4, 2006
Last modified: March 16, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.