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Protein

Calumenin

Gene

calu

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi81 – 921PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi117 – 1282PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi164 – 1753; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi201 – 2124PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi242 – 2535PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi278 – 2896PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Gene namesi
Name:calu
ORF Names:TNeu055n17.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1007422. calu.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000036419820 – 315CalumeninAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ28BT4.
PRIDEiQ28BT4.

Interactioni

Subunit structurei

Interacts with ggcx.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049856.

Structurei

3D structure databases

ProteinModelPortaliQ28BT4.
SMRiQ28BT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 103EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini104 – 139EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini188 – 223EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini229 – 264EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini265 – 300EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 315Prevents secretion from ERBy similarity4

Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ28BT4.
OMAiNVERQWQ.
OrthoDBiEOG091G0GUL.

Family and domain databases

InterProiView protein in InterPro
IPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PANTHERiPTHR10827:SF70. PTHR10827:SF70. 1 hit.
PfamiView protein in Pfam
PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 6 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28BT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRRLLLCL CLWVACVVSK PTEKKDRVHH DPQLSEKVHD DAQNFDYDHD
60 70 80 90 100
AFLGAEEAKT FDQLTPEESK ERLGMIVSKI DLDNDGYVTE GELTAWIKKA
110 120 130 140 150
QKKYVYDNVE RQWQEFDLNQ DGLVSWDEYR NVTYGTYLDD PDPDNSFNYK
160 170 180 190 200
QMMVRDERRF KMADQDGDLI ATKEEFTAFL HPEEFDYMKD IVVLETMEDI
210 220 230 240 250
DKNGDGLIDL EEYIGDMYNH DGDANEPEWV KTEREQFVEF RDKNHDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAES RHLVYESDQN KDSKLTREEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Length:315
Mass (Da):37,156
Last modified:April 4, 2006 - v1
Checksum:iC5A4A29AB05091EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942649 mRNA. Translation: CAJ82342.1.
RefSeqiXP_012814244.1. XM_012958790.2.
UniGeneiStr.11110.

Genome annotation databases

GeneIDi407965.

Similar proteinsi

Entry informationi

Entry nameiCALU_XENTR
AccessioniPrimary (citable) accession number: Q28BT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 4, 2006
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families