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Q28BL7 (PO2F1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
Octamer-binding protein 1
Short name=Oct-1
Octamer-binding transcription factor 1
Short name=OTF-1
Gene names
Name:pou2f1
Synonyms:oct-1, oct1
ORF Names:TEgg001p15.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and histone H2B. Acts downstream of Notch signaling during radial glia formation. Regulates apoptosis, possibly via an FGF-signaling pathway By similarity. UniProtKB P16143

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Retained in the cytoplasm during early development, then gradually translocates to the nucleus around the mid-blastula transition (MBT) By similarity. UniProtKB P16143

Domain

The POU domain controls nuclear translocation By similarity. UniProtKB P16143

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757POU domain, class 2, transcription factor 1
PRO_0000389618

Regions

Domain294 – 36875POU-specific
DNA binding395 – 45460Homeobox
Compositional bias47 – 282236Gln-rich
Compositional bias479 – 591113Thr-rich

Sequences

Sequence LengthMass (Da)Tools
Q28BL7 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 65AD8A5AF51B02E2

FASTA75778,444
        10         20         30         40         50         60 
MKLHSSSKIP NHAWLSDARM NNPSETSKSS ESGDGNTGTQ TNGLDFQKQA VPIGAITSAQ 

        70         80         90        100        110        120 
AQALLGHLHQ VQLAGTSLQA AAQSLNVQTK FKEEPGEPTQ AVQPSQQPSL QAAIPQTQLM 

       130        140        150        160        170        180 
VAGGPITGLT LTPAQQQLLL QQAQAQLLAA AVQHSASQQH SAAGATISAS AATPMTQIPL 

       190        200        210        220        230        240 
SQPIQIAQDL QQLQQLQQQN LNLQQFVLVH PTTNLPPAQF IISQTPQGQQ GLLQAQNLLT 

       250        260        270        280        290        300 
QLPQQSQANL LQSQPSITLT SQPATPTRTI AATPVQQLPQ SQTTPKRIDT PSLEEPSDLE 

       310        320        330        340        350        360 
ELEQFAKTFK QRRIKLGFTQ GDVGLAMGKL YGNDFSQTTI SRFEALNLSF KNMCKLKPLL 

       370        380        390        400        410        420 
EKWLNDAENI TSDSSLSNQS VLNSPGHGME GLNRRRKKRT SIETNIRVAL EKSFLENQKP 

       430        440        450        460        470        480 
TSEEITMIAD QLNMEKEVIR VWFCNRRQKE KRINPPSSGG SSSSPIKSLF SSANPLVATT 

       490        500        510        520        530        540 
PSLVTSSTAT TLTVNPVLPL TSAAAITSFP VPGTTGTSSA NTATVISTAP PVSSVLTSPS 

       550        560        570        580        590        600 
LSPSPSATAA TSEASTASGT STTHTTSTPL TSPLSTGQVM VTASGIHTAA TALQGAAQLP 

       610        620        630        640        650        660 
TSASLAAMAA AAGLNPGLMA PSQFAAGGAL FSLNPGALGS ALSPALMSNS TLATIQALAS 

       670        680        690        700        710        720 
SGSLPITSLD ATGNLVFANA GGTPNIVTAP LFLNPQNLSL LTSNPVSLVS AASTGVTGPI 

       730        740        750 
TSLHATTSSV DSVQNTLFTV ASASGAASTT TSASKAQ 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR942771 mRNA. Translation: CAJ82126.1.
RefSeqNP_001016337.2. NM_001016337.3.
UniGeneStr.48304.

3D structure databases

ProteinModelPortalQ28BL7.
SMRQ28BL7. Positions 295-455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000013682.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID549091.
KEGGxtr:549091.

Organism-specific databases

CTD5451.
XenbaseXB-GENE-853992. pou2f1.

Phylogenomic databases

eggNOGNOG267922.
HOGENOMHOG000220842.
HOVERGENHBG057016.
KOK09364.

Gene expression databases

BgeeQ28BL7.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePO2F1_XENTR
AccessionPrimary (citable) accession number: Q28BL7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families