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Q28BL7

- PO2F1_XENTR

UniProt

Q28BL7 - PO2F1_XENTR

Protein

POU domain, class 2, transcription factor 1

Gene

pou2f1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and histone H2B. Acts downstream of Notch signaling during radial glia formation. Regulates apoptosis, possibly via an FGF-signaling pathway By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi395 – 45460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. Notch signaling pathway Source: UniProtKB
    2. positive regulation of transcription, DNA-templated Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. radial glial cell differentiation Source: UniProtKB
    5. regulation of apoptotic process Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 1Imported
    Alternative name(s):
    Octamer-binding protein 1
    Short name:
    Oct-1By similarity
    Octamer-binding transcription factor 1By similarity
    Short name:
    OTF-1
    Gene namesi
    Name:pou2f1Imported
    Synonyms:oct-1By similarity, oct1By similarity
    ORF Names:TEgg001p15.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-853992. pou2f1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarityPROSITE-ProRule annotation
    Note: Retained in the cytoplasm during early development, then gradually translocates to the nucleus around the mid-blastula transition (MBT).By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757POU domain, class 2, transcription factor 1PRO_0000389618Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ28BL7.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000013682.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28BL7.
    SMRiQ28BL7. Positions 295-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini294 – 36875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi47 – 282236Gln-richSequence AnalysisAdd
    BLAST
    Compositional biasi479 – 591113Thr-richSequence AnalysisAdd
    BLAST

    Domaini

    The POU domain controls nuclear translocation.By similarity

    Sequence similaritiesi

    Belongs to the POU transcription factor family. Class-2 subfamily.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOGENOMiHOG000220842.
    HOVERGENiHBG057016.
    KOiK09364.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28BL7-1 [UniParc]FASTAAdd to Basket

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    MKLHSSSKIP NHAWLSDARM NNPSETSKSS ESGDGNTGTQ TNGLDFQKQA    50
    VPIGAITSAQ AQALLGHLHQ VQLAGTSLQA AAQSLNVQTK FKEEPGEPTQ 100
    AVQPSQQPSL QAAIPQTQLM VAGGPITGLT LTPAQQQLLL QQAQAQLLAA 150
    AVQHSASQQH SAAGATISAS AATPMTQIPL SQPIQIAQDL QQLQQLQQQN 200
    LNLQQFVLVH PTTNLPPAQF IISQTPQGQQ GLLQAQNLLT QLPQQSQANL 250
    LQSQPSITLT SQPATPTRTI AATPVQQLPQ SQTTPKRIDT PSLEEPSDLE 300
    ELEQFAKTFK QRRIKLGFTQ GDVGLAMGKL YGNDFSQTTI SRFEALNLSF 350
    KNMCKLKPLL EKWLNDAENI TSDSSLSNQS VLNSPGHGME GLNRRRKKRT 400
    SIETNIRVAL EKSFLENQKP TSEEITMIAD QLNMEKEVIR VWFCNRRQKE 450
    KRINPPSSGG SSSSPIKSLF SSANPLVATT PSLVTSSTAT TLTVNPVLPL 500
    TSAAAITSFP VPGTTGTSSA NTATVISTAP PVSSVLTSPS LSPSPSATAA 550
    TSEASTASGT STTHTTSTPL TSPLSTGQVM VTASGIHTAA TALQGAAQLP 600
    TSASLAAMAA AAGLNPGLMA PSQFAAGGAL FSLNPGALGS ALSPALMSNS 650
    TLATIQALAS SGSLPITSLD ATGNLVFANA GGTPNIVTAP LFLNPQNLSL 700
    LTSNPVSLVS AASTGVTGPI TSLHATTSSV DSVQNTLFTV ASASGAASTT 750
    TSASKAQ 757
    Length:757
    Mass (Da):78,444
    Last modified:April 4, 2006 - v1
    Checksum:i65AD8A5AF51B02E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR942771 mRNA. Translation: CAJ82126.1.
    RefSeqiNP_001016337.2. NM_001016337.3.
    UniGeneiStr.48304.

    Genome annotation databases

    GeneIDi549091.
    KEGGixtr:549091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR942771 mRNA. Translation: CAJ82126.1 .
    RefSeqi NP_001016337.2. NM_001016337.3.
    UniGenei Str.48304.

    3D structure databases

    ProteinModelPortali Q28BL7.
    SMRi Q28BL7. Positions 295-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000013682.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 549091.
    KEGGi xtr:549091.

    Organism-specific databases

    CTDi 5451.
    Xenbasei XB-GENE-853992. pou2f1.

    Phylogenomic databases

    eggNOGi NOG267922.
    HOGENOMi HOG000220842.
    HOVERGENi HBG057016.
    KOi K09364.

    Gene expression databases

    Bgeei Q28BL7.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EggImported.

    Entry informationi

    Entry nameiPO2F1_XENTR
    AccessioniPrimary (citable) accession number: Q28BL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3