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Q28BL7

- PO2F1_XENTR

UniProt

Q28BL7 - PO2F1_XENTR

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Protein

POU domain, class 2, transcription factor 1

Gene
pou2f1, oct-1, oct1, TEgg001p15.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and histone H2B. Acts downstream of Notch signaling during radial glia formation. Regulates apoptosis, possibly via an FGF-signaling pathway By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi395 – 45460HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. Notch signaling pathway Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. radial glial cell differentiation Source: UniProtKB
  5. regulation of apoptotic process Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
Gene namesi
Name:pou2f1
Synonyms:oct-1, oct1
ORF Names:TEgg001p15.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-853992. pou2f1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Retained in the cytoplasm during early development, then gradually translocates to the nucleus around the mid-blastula transition (MBT) By similarity.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757POU domain, class 2, transcription factor 1PRO_0000389618Add
BLAST

Expressioni

Gene expression databases

BgeeiQ28BL7.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000013682.

Structurei

3D structure databases

ProteinModelPortaliQ28BL7.
SMRiQ28BL7. Positions 295-455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 36875POU-specificAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 282236Gln-richAdd
BLAST
Compositional biasi479 – 591113Thr-richAdd
BLAST

Domaini

The POU domain controls nuclear translocation By similarity.By similarity

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
HOGENOMiHOG000220842.
HOVERGENiHBG057016.
KOiK09364.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28BL7-1 [UniParc]FASTAAdd to Basket

« Hide

MKLHSSSKIP NHAWLSDARM NNPSETSKSS ESGDGNTGTQ TNGLDFQKQA    50
VPIGAITSAQ AQALLGHLHQ VQLAGTSLQA AAQSLNVQTK FKEEPGEPTQ 100
AVQPSQQPSL QAAIPQTQLM VAGGPITGLT LTPAQQQLLL QQAQAQLLAA 150
AVQHSASQQH SAAGATISAS AATPMTQIPL SQPIQIAQDL QQLQQLQQQN 200
LNLQQFVLVH PTTNLPPAQF IISQTPQGQQ GLLQAQNLLT QLPQQSQANL 250
LQSQPSITLT SQPATPTRTI AATPVQQLPQ SQTTPKRIDT PSLEEPSDLE 300
ELEQFAKTFK QRRIKLGFTQ GDVGLAMGKL YGNDFSQTTI SRFEALNLSF 350
KNMCKLKPLL EKWLNDAENI TSDSSLSNQS VLNSPGHGME GLNRRRKKRT 400
SIETNIRVAL EKSFLENQKP TSEEITMIAD QLNMEKEVIR VWFCNRRQKE 450
KRINPPSSGG SSSSPIKSLF SSANPLVATT PSLVTSSTAT TLTVNPVLPL 500
TSAAAITSFP VPGTTGTSSA NTATVISTAP PVSSVLTSPS LSPSPSATAA 550
TSEASTASGT STTHTTSTPL TSPLSTGQVM VTASGIHTAA TALQGAAQLP 600
TSASLAAMAA AAGLNPGLMA PSQFAAGGAL FSLNPGALGS ALSPALMSNS 650
TLATIQALAS SGSLPITSLD ATGNLVFANA GGTPNIVTAP LFLNPQNLSL 700
LTSNPVSLVS AASTGVTGPI TSLHATTSSV DSVQNTLFTV ASASGAASTT 750
TSASKAQ 757
Length:757
Mass (Da):78,444
Last modified:April 4, 2006 - v1
Checksum:i65AD8A5AF51B02E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR942771 mRNA. Translation: CAJ82126.1.
RefSeqiNP_001016337.2. NM_001016337.3.
UniGeneiStr.48304.

Genome annotation databases

GeneIDi549091.
KEGGixtr:549091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR942771 mRNA. Translation: CAJ82126.1 .
RefSeqi NP_001016337.2. NM_001016337.3.
UniGenei Str.48304.

3D structure databases

ProteinModelPortali Q28BL7.
SMRi Q28BL7. Positions 295-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000013682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 549091.
KEGGi xtr:549091.

Organism-specific databases

CTDi 5451.
Xenbasei XB-GENE-853992. pou2f1.

Phylogenomic databases

eggNOGi NOG267922.
HOGENOMi HOG000220842.
HOVERGENi HBG057016.
KOi K09364.

Gene expression databases

Bgeei Q28BL7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiPO2F1_XENTR
AccessioniPrimary (citable) accession number: Q28BL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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