Reviewed, UniProtKB/Swiss-Prot Q28BL6 (AACS_XENTR)

Names and origin

Protein names

Recommended name:
    Acetoacetyl-CoA synthetase
    EC=6.2.1.16

Gene names

Name:	aacs
ORF Names:	TEgg036g05.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Activates acetoacetate to acetoacetyl-CoA By similarity.
Catalytic activity	ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetoacetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 672	672	Acetoacetyl-CoA synthetase		PRO_0000315790

Sequences

	Sequence		Length	Mass (Da)
	Q28BL6-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 5C2A9077295F3D2A	FASTA	672	75,168
	10 20 30 40 50 60 MSDKGELMEE IMEAKVMWYP DSKKITQMDQ FRNRVNRNLG LRLANYNELY QWSVEFYPEF 70 80 90 100 110 120 WAEFWDFSGI VYSKTYDEVI DRSKGIADVP EWFKGSRLNY AENLLKHKEN DKIALYSARE 130 140 150 160 170 180 GKENIEKVTF AELRRDVALF AAAMRKMGIK TGDRVAGYLP NCIQTVEAML AAASIGAIWS 190 200 210 220 230 240 ATSPDFGVNG VLDRFSQIQP KLILSVESVI YNGKEHCHLE KLQHVVKGLP DLKKVVVIPY 250 260 270 280 290 300 VLPKEKIDIS KIPNSMFLDE FLATGKVGDQ SPQLEFEQLP FNHPLYIMYS SGTTGAPKCM 310 320 330 340 350 360 VHSAGGTLIK HLTEHILHGS TTSSDVIMYY TTAGWMMWNW LITAVATGAS LVLYDGSPLV 370 380 390 400 410 420 PSLNVLWDLV DRLGITILGT GAKWLAVLED KGLKPCNTHS LQTLHTILST GSPLKPQSYE 430 440 450 460 470 480 YVYKHIKSNV LLGSVSGGTD IIACFMGQNV SVPVYKGEIQ ARHLGMAIEA WNEEGEAVLG 490 500 510 520 530 540 ESGELVCLKP LPSQPTHFWN DENGSKYQKA YFAKFPGVWA HGDYCKINPK TGGIVMLGRS 550 560 570 580 590 600 DGTLNPNGVR FGSSEIYNIV EAFVEVSDSL CVPQYNKDGD ERVILFLKMA DKFEFSKELL 610 620 630 640 650 660 KRIKDAIRVA LSARHVPALI LETKDIPYTI SGKKVEVAVK QVIAGKEVPH RGAFSNPQSL 670 DLYRNIPELQ NF

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR942772 mRNA. Translation: CAJ81897.1.
RefSeq	NP_001039244.1.
UniGene	Str.12148
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	734109.
KEGG	xtr:734109.
Organism-specific databases
Xenbase	XB-FEAT-490084. aacs.
Phylogenomic databases
HOVERGEN	Q28BL6.
Enzyme and pathway databases
BRENDA	6.2.1.16. 279072.
Family and domain databases
InterPro	IPR005914. Acac_CoA_synth. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AACS_XENTR

Accession

Primary (citable) accession number: Q28BL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project