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Q28BL6 (AACS_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetoacetyl-CoA synthetase
EC=6.2.1.16
Gene names
Name:aacs
ORF Names:TEgg036g05.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length672 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activates acetoacetate to acetoacetyl-CoA By similarity.

Catalytic activity

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.

Subcellular location

Cytoplasm › cytosol By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetoacetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 672672Acetoacetyl-CoA synthetase
PRO_0000315790

Sequences

Sequence LengthMass (Da)Tools
Q28BL6 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 5C2A9077295F3D2A

FASTA67275,168
        10         20         30         40         50         60 
MSDKGELMEE IMEAKVMWYP DSKKITQMDQ FRNRVNRNLG LRLANYNELY QWSVEFYPEF 

        70         80         90        100        110        120 
WAEFWDFSGI VYSKTYDEVI DRSKGIADVP EWFKGSRLNY AENLLKHKEN DKIALYSARE 

       130        140        150        160        170        180 
GKENIEKVTF AELRRDVALF AAAMRKMGIK TGDRVAGYLP NCIQTVEAML AAASIGAIWS 

       190        200        210        220        230        240 
ATSPDFGVNG VLDRFSQIQP KLILSVESVI YNGKEHCHLE KLQHVVKGLP DLKKVVVIPY 

       250        260        270        280        290        300 
VLPKEKIDIS KIPNSMFLDE FLATGKVGDQ SPQLEFEQLP FNHPLYIMYS SGTTGAPKCM 

       310        320        330        340        350        360 
VHSAGGTLIK HLTEHILHGS TTSSDVIMYY TTAGWMMWNW LITAVATGAS LVLYDGSPLV 

       370        380        390        400        410        420 
PSLNVLWDLV DRLGITILGT GAKWLAVLED KGLKPCNTHS LQTLHTILST GSPLKPQSYE 

       430        440        450        460        470        480 
YVYKHIKSNV LLGSVSGGTD IIACFMGQNV SVPVYKGEIQ ARHLGMAIEA WNEEGEAVLG 

       490        500        510        520        530        540 
ESGELVCLKP LPSQPTHFWN DENGSKYQKA YFAKFPGVWA HGDYCKINPK TGGIVMLGRS 

       550        560        570        580        590        600 
DGTLNPNGVR FGSSEIYNIV EAFVEVSDSL CVPQYNKDGD ERVILFLKMA DKFEFSKELL 

       610        620        630        640        650        660 
KRIKDAIRVA LSARHVPALI LETKDIPYTI SGKKVEVAVK QVIAGKEVPH RGAFSNPQSL 

       670 
DLYRNIPELQ NF

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR942772 mRNA. Translation: CAJ81897.1.
RefSeqNP_001039244.1. NM_001045779.1.
UniGeneStr.12148.

3D structure databases

ProteinModelPortalQ28BL6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ28BL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID734109.
KEGGxtr:734109.

Organism-specific databases

CTD65985.
XenbaseXB-GENE-490085. aacs.

Phylogenomic databases

eggNOGveNOG04053.
GeneTreeENSGT00580000081632.
HOVERGENHBG059947.

Family and domain databases

InterProIPR005914. Acac_CoA_synth.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01907.
PANTHERPTHR24095:SF40. PTHR24095:SF40. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR01217. Ac_ac_CoA_syn. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACS_XENTR
AccessionPrimary (citable) accession number: Q28BL6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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