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Q289L8

- PB1F2_I00A1

UniProt

Q289L8 - PB1F2_I00A1

Protein

Protein PB1-F2

Gene

PB1-F2

Organism
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. modulation by virus of host apoptotic process Source: UniProtKB-KW
    3. suppression by virus of host MAVS activity Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PB1-F2
    Gene namesi
    Name:PB1-F2
    OrganismiInfluenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
    Taxonomic identifieri363066 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]

    Subcellular locationi

    Host mitochondrion inner membrane. Host nucleus. Host cytoplasmhost cytosol
    Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol By similarity.By similarity

    GO - Cellular componenti

    1. host cell cytosol Source: UniProtKB-SubCell
    2. host cell mitochondrial inner membrane Source: UniProtKB-SubCell
    3. host cell nucleus Source: UniProtKB-SubCell
    4. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host cytoplasm, Host membrane, Host mitochondrion, Host mitochondrion inner membrane, Host nucleus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5757Protein PB1-F2PRO_0000373010Add
    BLAST

    Interactioni

    Subunit structurei

    Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the influenza viruses PB1-F2 family.Curated

    Family and domain databases

    InterProiIPR021045. Flu_proapoptotic_PB1-F2.
    [Graphical view]
    PfamiPF11986. PB1-F2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q289L8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQEQGTPWI QSTGHISTQK EEDGQKIPKL EHRNSTQLMG HYQKTMNQVA   50
    MPKQIVY 57
    Length:57
    Mass (Da):6,568
    Last modified:April 4, 2006 - v1
    Checksum:i53B0088801DD220C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY009210 Genomic RNA. Translation: ABD61527.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY009210 Genomic RNA. Translation: ABD61527.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR021045. Flu_proapoptotic_PB1-F2.
    [Graphical view ]
    Pfami PF11986. PB1-F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. The NIAID Influenza Genome Sequencing Consortium
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPB1F2_I00A1
    AccessioniPrimary (citable) accession number: Q289L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Is not encoded in all strains, and seems to be dispensable for replication.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3