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Protein

Apolipoprotein E

Gene

APOE

Organism
Saimiri sciureus (Common squirrel monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiSaimiri sciureus (Common squirrel monkey)
Taxonomic identifieri9521 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000191638‹1 – ›107Apolipoprotein EAdd BLAST›107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74Methionine sulfoxideBy similarity1
Modified residuei78PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Oxidation, Phosphoprotein

Expressioni

Tissue specificityi

Secreted in plasma.

Structurei

3D structure databases

ProteinModelPortaliQ28995.
SMRiQ28995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 321Add BLAST22
Repeati33 – 542Add BLAST22
Repeati55 – 763Add BLAST22
Repeati77 – 984Add BLAST22
Repeati99 – ›1075›9

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – ›1075 X 22 AA approximate tandem repeatsAdd BLAST›97
Regioni89 – 99LDL receptor bindingBy similarityAdd BLAST11
Regioni93 – 96Heparin-bindingBy similarity4

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q28995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSSQVTQELT ALMDETMKEL KAYKSELEEQ LSPVAEETRA RLSKELQAAQ
60 70 80 90 100
ARLGADMEDV RSRLAQYRSE VQAMLGQSTD ELRARLASHL RKLRKRLLRD

VDDLQKR
Length:107
Mass (Da):12,328
Last modified:November 1, 1996 - v1
Checksum:iFF88CED47BD18F7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1071

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52029 mRNA. Translation: AAC50442.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPOE_SAISC
AccessioniPrimary (citable) accession number: Q28995
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families