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Protein

Ameloblastin

Gene

AMBN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the mineralization and structural organization of enamel.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Ameloblastin
Alternative name(s):
Sheathlin
Gene namesi
Name:AMBN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000119427 – 421AmeloblastinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Hydroxyproline1 Publication1
Modified residuei43Phosphoserine1 Publication1
Glycosylationi112O-linked (GalNAc...)1 Publication1

Keywords - PTMi

Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDbiQ28989.
PRIDEiQ28989.

PTM databases

iPTMnetiQ28989.

Miscellaneous databases

PMAP-CutDBQ28989.

Expressioni

Tissue specificityi

Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.

Gene expression databases

GenevisibleiQ28989. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009536.

Family & Domainsi

Sequence similaritiesi

Belongs to the ameloblastin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IMU1. Eukaryota.
ENOG41128SS. LUCA.
GeneTreeiENSGT00390000018227.
HOGENOMiHOG000033918.
HOVERGENiHBG007128.
InParanoidiQ28989.
OMAiWMHGLLP.
OrthoDBiEOG091G0EPP.
TreeFamiTF337860.

Family and domain databases

InterProiIPR007798. Amelin.
[Graphical view]
PANTHERiPTHR14115. PTHR14115. 1 hit.
PfamiPF05111. Amelin. 1 hit.
[Graphical view]
SMARTiSM00817. Amelin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q28989-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPALKIPLFK MKDMVLILCL LKMSSAVPAF PRQPGTPGVA SLSLETMRQL
60 70 80 90 100
GSLQGLNMLS QYSRFGFGKS FNSLWMHGLL PPHSSFQWMR PREHETQQYE
110 120 130 140 150
YSLPVHPPPL PSQPSLQPQQ PGQKPFLQPT VVTSIQNPVQ KGVPQPPIYQ
160 170 180 190 200
GHPPLQQVEG PMVQQQVAPS EKPPEAELPG LDFADPQDPS MFPIARLISQ
210 220 230 240 250
GPVPQDKPSP LYPGMFYMSY GANQLNSPAR LGILSSEEMA GGRGGPLAYG
260 270 280 290 300
AMFPGFGGMR PNLGGMPPNS AKGGDFTLEF DSPAAGTKGP EKGEGGAEGS
310 320 330 340 350
PVAEANTADP ESPALFSEVA SGVLGGLLAN PKGKIPNLAR GPAGRSRGPP
360 370 380 390 400
GVTPADADPL MTPGLADAYE TYGADETTTL GLQEEMTMDS TATPYSEHTS
410 420
MPGNKAQQPQ IKRDAWRFQE P
Length:421
Mass (Da):44,927
Last modified:November 1, 1996 - v1
Checksum:i3610D6D9F16F9BFC
GO
Isoform 2 (identifier: Q28989-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-113: Missing.

Show »
Length:406
Mass (Da):43,221
Checksum:i541F7AD5EBE4609E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00022599 – 113Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43404 mRNA. Translation: AAA85588.1.
RefSeqiNP_999202.1. NM_214037.1. [Q28989-1]
UniGeneiSsc.140.

Genome annotation databases

EnsembliENSSSCT00000009789; ENSSSCP00000009536; ENSSSCG00000008937. [Q28989-1]
GeneIDi397102.
KEGGissc:397102.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43404 mRNA. Translation: AAA85588.1.
RefSeqiNP_999202.1. NM_214037.1. [Q28989-1]
UniGeneiSsc.140.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009536.

PTM databases

iPTMnetiQ28989.

Proteomic databases

PaxDbiQ28989.
PRIDEiQ28989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000009789; ENSSSCP00000009536; ENSSSCG00000008937. [Q28989-1]
GeneIDi397102.
KEGGissc:397102.

Organism-specific databases

CTDi258.

Phylogenomic databases

eggNOGiENOG410IMU1. Eukaryota.
ENOG41128SS. LUCA.
GeneTreeiENSGT00390000018227.
HOGENOMiHOG000033918.
HOVERGENiHBG007128.
InParanoidiQ28989.
OMAiWMHGLLP.
OrthoDBiEOG091G0EPP.
TreeFamiTF337860.

Miscellaneous databases

PMAP-CutDBQ28989.

Gene expression databases

GenevisibleiQ28989. SS.

Family and domain databases

InterProiIPR007798. Amelin.
[Graphical view]
PANTHERiPTHR14115. PTHR14115. 1 hit.
PfamiPF05111. Amelin. 1 hit.
[Graphical view]
SMARTiSM00817. Amelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMBN_PIG
AccessioniPrimary (citable) accession number: Q28989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.