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Protein
Submitted name:

Prohormone convertase

Gene

PC1/3

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertaseImported
Gene namesi
Name:PC1/3Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 PotentialImportedAdd
BLAST
Chaini28 – 753726prohormone convertaseImportedPRO_5000144515Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015068.

Structurei

3D structure databases

ProteinModelPortaliQ28959.
SMRiQ28959. Positions 31-103, 122-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation
Contains peptidase S8 domain.SAAS annotation
Contains peptidase Sdomain.SAAS annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG1404.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK01359.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRAWTLQC TAFTLFCAWC ALNSVKAKRQ FVNEWAAEIP GGPEAASAIA
60 70 80 90 100
EELGYDLLGQ IGSLENHYLF KHKSHPRRSR RSALHITKRL SDDDRVIWAE
110 120 130 140 150
QQYEKERSKR SLLRDSALNL FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP
160 170 180 190 200
VWQKGITGKG VVITVLDDGL EWNHTDIYAN YDPEASYDFN DNDHDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNHKCGVGVA YNSKVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATSYSSGDY TDQRITSADL HDDCTETHTG TSASAPLAAG IFALALEANP
410 420 430 440 450
NLTWRDMQHL VVWTSEYDPL ANNPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPRTWSS VPEKKECVVK DNDFEPRALK ANGEVIIEIP TRACEPQENA
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TGTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPIGTWTLR ITDMSGRMQN EGRIVNWKLI LHGTSSQPEH
610 620 630 640 650
MKQPRVYTSY NTVQNDRRGV EKVVDSEEEQ PTQENLNESP LVSKSPSGSS
660 670 680 690 700
VGGRREELAE GAPSEAMLRL LQSAFSKNSA PKQSPKKSAS VKLNIPYENF
710 720 730 740 750
YEALEKLNQP SQLKDSEDSL YNDYVDVFYN TKPYKHRDDR LLQALVDILR

EEN
Length:753
Mass (Da):84,083
Last modified:November 1, 1996 - v1
Checksum:i6F06D3F16AB16BE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20545 mRNA. Translation: AAA85577.1.
PIRiS59959.
RefSeqiNP_999203.1. NM_214038.1.
UniGeneiSsc.92884.

Genome annotation databases

GeneIDi397103.
KEGGissc:397103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20545 mRNA. Translation: AAA85577.1.
PIRiS59959.
RefSeqiNP_999203.1. NM_214038.1.
UniGeneiSsc.92884.

3D structure databases

ProteinModelPortaliQ28959.
SMRiQ28959. Positions 31-103, 122-597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015068.

Protein family/group databases

MEROPSiS08.072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397103.
KEGGissc:397103.

Organism-specific databases

CTDi5122.

Phylogenomic databases

eggNOGiCOG1404.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK01359.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of multiple prohormone convertase PC1/3 transcripts in porcine ovary."
    Dai G., Smeekens S.P., Steiner D.F., McMurtry J.P., Kwok S.C.
    Biochim. Biophys. Acta 1264:1-6(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.
  2. Kwok S.C.M.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.

Entry informationi

Entry nameiQ28959_PIG
AccessioniPrimary (citable) accession number: Q28959
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.