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Protein

Cathepsin L1

Gene

CTSL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Important for the overall degradation of proteins in lysosomes.

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381By similarity
Active sitei277 – 2771By similarity
Active sitei301 – 3011By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiI29.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L1 (EC:3.4.22.15)
Alternative name(s):
Cathepsin L
Cleaved into the following 2 chains:
Gene namesi
Name:CTSL
Synonyms:CTSL1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Propeptidei18 – 117100Activation peptidePRO_0000026252Add
BLAST
Chaini118 – 289172Cathepsin L1 heavy chainPRO_0000026253Add
BLAST
Propeptidei290 – 2912By similarityPRO_0000026254
Chaini292 – 33443Cathepsin L1 light chainPRO_0000026255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi135 ↔ 178By similarity
Disulfide bondi169 ↔ 212By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi270 ↔ 323Interchain (between heavy and light chains)By similarity
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ28944.
PeptideAtlasiQ28944.

Expressioni

Gene expression databases

BgeeiENSSSCG00000011171.
GenevisibleiQ28944. SS.

Interactioni

Subunit structurei

Dimer of a heavy and a light chain linked by disulfide bonds.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011919.

Structurei

3D structure databases

ProteinModelPortaliQ28944.
SMRiQ28944. Positions 21-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
InParanoidiQ28944.
KOiK01365.
OMAiSKFWIVK.
OrthoDBiEOG091G0AKT.
TreeFamiTF313739.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSLFLTAL CLGIASAAPK LDQNLDADWY KWKATHGRLY GMNEEGWRRA
60 70 80 90 100
VWEKNMKMIE LHNQEYSQGK HGFSMAMNAF GDMTNEEFRQ VMNGFQNQKH
110 120 130 140 150
KKGKVFHESL VLEVPKSVDW REKGYVTAVK NQGQCGSCWA FSATGALEGQ
160 170 180 190 200
MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GLMDNAFQYV KDNGGLDTEE
210 220 230 240 250
SYPYLGRETN SCTYKPECSA ANDTGFVDIP QREKALMKAV ATVGPISVAI
260 270 280 290 300
DAGHSSFQFY KSGIYYDPDC SSKDLDHGVL VVGYGFEGTD SNSSKFWIVK
310 320 330
NSWGPEWGWN GYVKMAKDQN NHCGISTAAS YPTV
Length:334
Mass (Da):37,178
Last modified:November 1, 1997 - v1
Checksum:i51DBA79ACCF2CE53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37917 mRNA. Translation: BAA07140.1.
AJ315771 Genomic DNA. Translation: CAC44793.1.
PIRiA58195.
RefSeqiNP_999057.1. NM_213892.1.
XP_005653866.1. XM_005653809.2.
XP_005653867.1. XM_005653810.2.
UniGeneiSsc.54036.

Genome annotation databases

EnsembliENSSSCT00000012233; ENSSSCP00000011919; ENSSSCG00000011171.
GeneIDi396926.
KEGGissc:396926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37917 mRNA. Translation: BAA07140.1.
AJ315771 Genomic DNA. Translation: CAC44793.1.
PIRiA58195.
RefSeqiNP_999057.1. NM_213892.1.
XP_005653866.1. XM_005653809.2.
XP_005653867.1. XM_005653810.2.
UniGeneiSsc.54036.

3D structure databases

ProteinModelPortaliQ28944.
SMRiQ28944. Positions 21-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011919.

Protein family/group databases

MEROPSiI29.010.

Proteomic databases

PaxDbiQ28944.
PeptideAtlasiQ28944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012233; ENSSSCP00000011919; ENSSSCG00000011171.
GeneIDi396926.
KEGGissc:396926.

Organism-specific databases

CTDi1515.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
InParanoidiQ28944.
KOiK01365.
OMAiSKFWIVK.
OrthoDBiEOG091G0AKT.
TreeFamiTF313739.

Gene expression databases

BgeeiENSSSCG00000011171.
GenevisibleiQ28944. SS.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATL1_PIG
AccessioniPrimary (citable) accession number: Q28944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.