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Protein

Interleukin-12 subunit beta

Gene

IL12B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.By similarity
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-SSC-447115. Interleukin-12 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit beta
Short name:
IL-12B
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunit
Short name:
CLMF p40
IL-12 subunit p40
Gene namesi
Name:IL12B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 324302Interleukin-12 subunit betaPRO_0000010935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 90PROSITE-ProRule annotation
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi195 – 195Interchain (with C-99 in IL12A)PROSITE-ProRule annotation
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28938.

Expressioni

Gene expression databases

GenevisibleiQ28938. SS.

Interactioni

Subunit structurei

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018057.

Structurei

3D structure databases

ProteinModelPortaliQ28938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 10684Ig-like C2-typeAdd
BLAST
Domaini233 – 32492Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IF5K. Eukaryota.
ENOG410YWXR. LUCA.
GeneTreeiENSGT00390000012630.
HOGENOMiHOG000113027.
HOVERGENiHBG052094.
InParanoidiQ28938.
KOiK05425.
OMAiWSTPHSY.
OrthoDBiEOG7TBC2K.
TreeFamiTF334829.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
[Graphical view]
PANTHERiPTHR11321. PTHR11321. 1 hit.
PfamiPF10420. IL12p40_C. 1 hit.
[Graphical view]
PIRSFiPIRSF038007. IL_12_beta. 1 hit.
PRINTSiPR01928. INTRLEUKN12B.
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLQQLVVSW FSLVWLASPI VAIWELEKNV YVVELDWYPN APGEMVVLTC
60 70 80 90 100
NTPEEDGITW TSDQSSEVLG TGKTLTIHVK EFGDAGQYTC RKGGAVLSQS
110 120 130 140 150
LLLLHKKEDG IWSTDILKDQ KEPKNKSFLK CEAKNYSGRF TCWWLTAIST
160 170 180 190 200
DLKFSVKSSR GSTDPRGVTC GTATLSEDLG EYKKYRVECQ EGSACPAAEE
210 220 230 240 250
SLPIEVVLEA VHKLKYENYT SSFFIRDIIK PDPPKNLQLN PLKNSRHVEI
260 270 280 290 300
SWEYPDTWST PHSYFSLMFG VQVQGKNKRE KKDKLFTDQI SAKVTCHKDA
310 320
NIRVQARDRY YSSSWSEWAS VSCN
Length:324
Mass (Da):36,829
Last modified:November 1, 1996 - v1
Checksum:iF0E48B72F700086C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08317 mRNA. Translation: AAA75356.1.
RefSeqiNP_999178.1. NM_214013.1.
UniGeneiSsc.71.

Genome annotation databases

EnsembliENSSSCT00000018557; ENSSSCP00000018057; ENSSSCG00000017044.
GeneIDi397076.
KEGGissc:397076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08317 mRNA. Translation: AAA75356.1.
RefSeqiNP_999178.1. NM_214013.1.
UniGeneiSsc.71.

3D structure databases

ProteinModelPortaliQ28938.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018057.

Proteomic databases

PaxDbiQ28938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018557; ENSSSCP00000018057; ENSSSCG00000017044.
GeneIDi397076.
KEGGissc:397076.

Organism-specific databases

CTDi3593.

Phylogenomic databases

eggNOGiENOG410IF5K. Eukaryota.
ENOG410YWXR. LUCA.
GeneTreeiENSGT00390000012630.
HOGENOMiHOG000113027.
HOVERGENiHBG052094.
InParanoidiQ28938.
KOiK05425.
OMAiWSTPHSY.
OrthoDBiEOG7TBC2K.
TreeFamiTF334829.

Enzyme and pathway databases

ReactomeiR-SSC-447115. Interleukin-12 signaling.

Gene expression databases

GenevisibleiQ28938. SS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
[Graphical view]
PANTHERiPTHR11321. PTHR11321. 1 hit.
PfamiPF10420. IL12p40_C. 1 hit.
[Graphical view]
PIRSFiPIRSF038007. IL_12_beta. 1 hit.
PRINTSiPR01928. INTRLEUKN12B.
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and mRNA expression of porcine interleukin-12."
    Foss D.L., Murtaugh M.P.
    Vet. Immunol. Immunopathol. 57:121-134(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiIL12B_PIG
AccessioniPrimary (citable) accession number: Q28938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.