Steroidogenic acute regulatory protein, mitochondrial precursor

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Q28918 (STAR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name=StAR

Alternative name(s):
START domain-containing protein 1
Short name=StARD1

Gene names

Name:

STAR

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone By similarity.
Pathway	Steroid metabolism; cholesterol metabolism.
Subunit structure	May interact with TSPO By similarity.
Subcellular location	Mitochondrion.
Tissue specificity	Corpus luteum and adrenal gland.
Sequence similarities	Contains 1 START domain.

Ontologies

Keywords
Biological process	Lipid transport Steroidogenesis Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular lipid metabolic process Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cholesterol transport Inferred from electronic annotation. Source: GOC glucocorticoid metabolic process Inferred from electronic annotation. Source: Compara regulation of steroid biosynthetic process Inferred from electronic annotation. Source: Compara steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cholesterol binding Inferred from electronic annotation. Source: Compara cholesterol transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 63

Mitochondrion By similarity

Chain

64 – 285

222

Steroidogenic acute regulatory protein, mitochondrial

PRO_0000033314

Regions

Domain

67 – 280

214

START

Amino acid modifications

Modified residue

Phosphoserine; by PKA By similarity

Modified residue

195

Phosphoserine; by PKA By similarity

Experimental info

Sequence conflict

Y → H in CAA76717. Ref.1

Sequence conflict

E → K in CAA76718. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q28918 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: FB5C4174FF888E55
Show »

FASTA

285

31,871

        10         20         30         40         50         60 
MLLATFKLCA GSSYRHVRSM KGLQQQAVLA IGQELNRRAL GGPAPAAWIN QVRRRGSLLG 

        70         80         90        100        110        120 
SQLEDPLYSD QELAYIQQGE EAMQRALGIL KDQEGWKKES RQANGDEVLS KVIPDVGKVF 

       130        140        150        160        170        180 
RLEVVVDQPM ERLYEELVER MEAMGEWNPN VKEIKVLQKI GKDTVITHEL AAEVAGNLVG 

       190        200        210        220        230        240 
PRDFVSVRCT KRRGSMCVLA GMATLYEEMP QQKGVIRAEH GPTCMVLRPL AGSPSRTKLT 

       250        260        270        280 
WLLSIDLKGW LPKTIINQVL SQTQVDFANH LRKRLESCPA LEARC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and in vivo expression of the bovine steroidogenic acute regulatory protein." Hartung S., Rust W., Balvers M., Ivell R. Biochem. Biophys. Res. Commun. 215:646-653(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Corpus luteum.
[2]	Hartung S., Rust W., Balvers M., Ivell R. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 85 AND 174.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.
[4]	"Comparison of protein phosphorylation patterns produced in adrenal cells by activation of cAMP-dependent protein kinase and Ca-dependent protein kinase." Hartigan J.A., Green E.G., Mortensen R.M., Menachery A., Williams G.H., Orme-Johnson N.R. J. Steroid Biochem. Mol. Biol. 53:95-101(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17259 mRNA. Translation: CAA76717.1. Y17260 Genomic DNA. Translation: CAA76718.1. BC110213 mRNA. Translation: AAI10214.1.
IPI	IPI00711400.
PIR	JC4315.
RefSeq	NP_776614.1. NM_174189.2.
UniGene	Bt.87242.
3D structure databases
ProteinModelPortal	Q28918.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000044633.
Proteomic databases
PRIDE	Q28918.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000047426; ENSBTAP00000044633; ENSBTAG00000033345.
GeneID	281507.
KEGG	bta:281507.
Organism-specific databases
CTD	6770.
Phylogenomic databases
eggNOG	NOG239518.
GeneTree	ENSGT00530000063139.
HOGENOM	HOG000142452.
HOVERGEN	HBG010529.
InParanoid	Q28918.
OMA	ATFKLCA.
OrthoDB	EOG4JWVF2.
Enzyme and pathway databases
UniPathway	UPA00296.
Family and domain databases
Gene3D	3.30.530.20. 1 hit.
InterPro	IPR000799. StAR. IPR023393. START-like_dom. IPR002913. START_lipid-bd_dom. [Graphical view]
Pfam	PF01852. START. 1 hit. [Graphical view]
PRINTS	PR00978. STARPROTEIN.
SMART	SM00234. START. 1 hit. [Graphical view]
PROSITE	PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805475.

Entry information

Entry name

STAR_BOVIN

Accession

Primary (citable) accession number: Q28918
Secondary accession number(s): Q2YDI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents