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Q28891 (S5A1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1

EC=1.3.1.22
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name=S5AR 1
Gene names
Name:SRD5A1
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activity

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

Subcellular location

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the steroid 5-alpha reductase family.

Biophysicochemical properties

pH dependence:

Optimally active at alkaline pHs.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2632633-oxo-5-alpha-steroid 4-dehydrogenase 1
PRO_0000213675

Regions

Transmembrane16 – 3318Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane213 – 23321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q28891 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8830E1FB8F7365C4

FASTA26330,018
        10         20         30         40         50         60 
MATAVAEELL LAEERMLAAL AYLQCAVGCA VLARNRETNL AYGRHASPSF RVRVPARAAW 

        70         80         90        100        110        120 
VVQELPSLAL PLYQYASESA PRLRSAPNCI LLAMFLVHYG HRCLIYPFLM RGGKPMPLLA 

       130        140        150        160        170        180 
CTMAIMFCTF NGYLQSRYLS HWAVYADDWV TDPRFLIGFG LWLAGMLINI HSDHILRNLR 

       190        200        210        220        230        240 
KPGDTGYKIP RGGLFEYVTA ANYFGEIMEW CGYALASWSV QGAAFAFFTF CFLSGRAKEH 

       250        260 
HRWYLQKFEE YPKFRKILIP FLF 

« Hide

References

[1]"Cloning, expression and functional characterization of type 1 and type 2 steroid 5 alpha-reductases from Cynomolgus monkey: comparisons with human and rat isoenzymes."
Levy M.A., Brandt M., Sheedy K.M., Holt D.A., Heaslip J.I., Trill J.J., Ryan P.J., Morris R.A., Garrison L.M., Bergsma D.J.
J. Steroid Biochem. Mol. Biol. 52:307-319(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S77162 mRNA. Translation: AAB34212.1.
RefSeqNP_001274227.1. NM_001287298.1.
UniGeneMfa.6683.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102126671.
KEGGmcf:102126671.

Organism-specific databases

CTD6715.

Phylogenomic databases

HOVERGENHBG003402.

Family and domain databases

InterProIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS5A1_MACFA
AccessionPrimary (citable) accession number: Q28891
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families