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Protein
Submitted name:

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CFA-140834. Extrinsic Pathway of Fibrin Clot Formation.

Protein family/group databases

MEROPSiI02.011.

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue factor pathway inhibitorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TFPIImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 36

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500770013629 – 396Sequence analysisAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000040632.

Structurei

3D structure databases

ProteinModelPortaliQ28874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 103BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini125 – 175BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini309 – 359BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Sequence similaritiesi

Contains 3 BPTI/Kunitz inhibitor domains.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
KOiK03909.
OMAiCHANINR.
OrthoDBiEOG091G14M8.
TreeFamiTF315349.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR029864. TFPI1.
[Graphical view]
PANTHERiPTHR10083:SF238. PTHR10083:SF238. 2 hits.
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYTMKKEQI FWVSTYLLLN CASAPLNAVL DESEEYPGIT DELPPLRLLH
60 70 80 90 100
SFCALKADNG PCRAMIRNYF FNIHTQQCEE FIYGGCEGNQ NRFESLEECE
110 120 130 140 150
EKCVRVYPKA KTETLEKVLE KPDYCHMNED SGLCRGFVTR YYYNNVSSKC
160 170 180 190 200
EGFKYGGCLG NLNNFETLEQ CKNTCEGSID LLMDETVNNT GSPGSMNNTS
210 220 230 240 250
LFNSGDSLLP ADSGDSMPPD SEIGGLQHDS ESGGLQHDSE SGGLQHDSES
260 270 280 290 300
GGLQHDSESG GLQHDSESGG LQHDSGDNTS PPVSVNNDSF TPRPPTVSSF
310 320 330 340 350
LEFYGPSWCL TPADRGLCHA NESRFYYNSV IGKCRPFKYS GCGGNENNFT
360 370 380 390
SKKACLTACK KGFMQRISKG GLIKTKRKRK KQTVKIVYEK IFVKKL
Length:396
Mass (Da):43,948
Last modified:November 1, 1996 - v1
Checksum:i50F65C8337A003D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03017869 Genomic DNA. No translation available.
S75369 mRNA. Translation: AAB32443.1.
RefSeqiNP_001003243.1. NM_001003243.2.
XP_005640240.1. XM_005640183.2.
UniGeneiCfa.3782.

Genome annotation databases

EnsembliENSCAFT00000023418; ENSCAFP00000021748; ENSCAFG00000014752.
ENSCAFT00000047260; ENSCAFP00000040632; ENSCAFG00000014752.
GeneIDi403921.
KEGGicfa:403921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03017869 Genomic DNA. No translation available.
S75369 mRNA. Translation: AAB32443.1.
RefSeqiNP_001003243.1. NM_001003243.2.
XP_005640240.1. XM_005640183.2.
UniGeneiCfa.3782.

3D structure databases

ProteinModelPortaliQ28874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000040632.

Protein family/group databases

MEROPSiI02.011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000023418; ENSCAFP00000021748; ENSCAFG00000014752.
ENSCAFT00000047260; ENSCAFP00000040632; ENSCAFG00000014752.
GeneIDi403921.
KEGGicfa:403921.

Organism-specific databases

CTDi7035.

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
KOiK03909.
OMAiCHANINR.
OrthoDBiEOG091G14M8.
TreeFamiTF315349.

Enzyme and pathway databases

ReactomeiR-CFA-140834. Extrinsic Pathway of Fibrin Clot Formation.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR029864. TFPI1.
[Graphical view]
PANTHERiPTHR10083:SF238. PTHR10083:SF238. 2 hits.
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ28874_CANLF
AccessioniPrimary (citable) accession number: Q28874
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.