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Protein
Submitted name:

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-140834 Extrinsic Pathway of Fibrin Clot Formation

Protein family/group databases

MEROPSiI02.011

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue factor pathway inhibitorImported
Gene namesi
Name:TFPIImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 36

Organism-specific databases

VGNCiVGNC:47301 TFPI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501410416629 – 396Sequence analysisAdd BLAST368

Expressioni

Gene expression databases

BgeeiENSCAFG00000014752

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000040632

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 103BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini125 – 175BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini309 – 359BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00740000114929
HOGENOMiHOG000231818
HOVERGENiHBG056804
KOiK03909
OMAiCHMNEDS
OrthoDBiEOG091G14M8
TreeFamiTF315349

Family and domain databases

CDDicd00109 KU, 3 hits
Gene3Di4.10.410.10, 3 hits
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR029864 TFPI1
PANTHERiPTHR10083:SF317 PTHR10083:SF317, 1 hit
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 3 hits
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 3 hits
SUPFAMiSSF57362 SSF57362, 3 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 3 hits
PS50279 BPTI_KUNITZ_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q28874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYTMKKEQI FWVSTYLLLN CASAPLNAVL DESEEYPGIT DELPPLRLLH
60 70 80 90 100
SFCALKADNG PCRAMIRNYF FNIHTQQCEE FIYGGCEGNQ NRFESLEECE
110 120 130 140 150
EKCVRVYPKA KTETLEKVLE KPDYCHMNED SGLCRGFVTR YYYNNVSSKC
160 170 180 190 200
EGFKYGGCLG NLNNFETLEQ CKNTCEGSID LLMDETVNNT GSPGSMNNTS
210 220 230 240 250
LFNSGDSLLP ADSGDSMPPD SEIGGLQHDS ESGGLQHDSE SGGLQHDSES
260 270 280 290 300
GGLQHDSESG GLQHDSESGG LQHDSGDNTS PPVSVNNDSF TPRPPTVSSF
310 320 330 340 350
LEFYGPSWCL TPADRGLCHA NESRFYYNSV IGKCRPFKYS GCGGNENNFT
360 370 380 390
SKKACLTACK KGFMQRISKG GLIKTKRKRK KQTVKIVYEK IFVKKL
Length:396
Mass (Da):43,948
Last modified:November 1, 1996 - v1
Checksum:i50F65C8337A003D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03017869 Genomic DNA No translation available.
S75369 mRNA Translation: AAB32443.1
RefSeqiNP_001003243.1, NM_001003243.2
XP_005640240.1, XM_005640183.2
UniGeneiCfa.3782

Genome annotation databases

EnsembliENSCAFT00000023418; ENSCAFP00000021748; ENSCAFG00000014752
ENSCAFT00000047260; ENSCAFP00000040632; ENSCAFG00000014752
GeneIDi403921
KEGGicfa:403921

Similar proteinsi

Entry informationi

Entry nameiQ28874_CANLF
AccessioniPrimary (citable) accession number: Q28874
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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