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Protein

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei64 – 65Reactive bondBy similarity2
Sitei135 – 136Reactive bondBy similarity2
Sitei227 – 228Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Protein family/group databases

MEROPSiI02.012

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor
Short name:
TFPI
Alternative name(s):
Extrinsic pathway inhibitor
Short name:
EPI
Lipoprotein-associated coagulation inhibitor
Short name:
LACI
Gene namesi
Name:TFPI
Synonyms:TFPI1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000001687229 – 304Tissue factor pathway inhibitorAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 104PROSITE-ProRule annotation
Disulfide bondi63 ↔ 87PROSITE-ProRule annotation
Disulfide bondi79 ↔ 100PROSITE-ProRule annotation
Disulfide bondi125 ↔ 175PROSITE-ProRule annotation
Disulfide bondi134 ↔ 158PROSITE-ProRule annotation
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 171PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 267PROSITE-ProRule annotation
Disulfide bondi226 ↔ 250PROSITE-ProRule annotation
Disulfide bondi242 ↔ 263PROSITE-ProRule annotation
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28864

Expressioni

Gene expression databases

BgeeiENSMMUG00000009448
ExpressionAtlasiQ28864 baseline

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012353

Structurei

3D structure databases

ProteinModelPortaliQ28864
SMRiQ28864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 104BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini125 – 175BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini217 – 267BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

Domaini

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
HOGENOMiHOG000231818
HOVERGENiHBG056804
InParanoidiQ28864
KOiK03909
OMAiFIQRISK
OrthoDBiEOG091G14M8
TreeFamiTF315349

Family and domain databases

CDDicd00109 KU, 3 hits
Gene3Di4.10.410.10, 3 hits
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008296 TFPI-like
IPR029864 TFPI1
PANTHERiPTHR10083:SF317 PTHR10083:SF317, 1 hit
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 3 hits
PIRSFiPIRSF001620 TFPI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 3 hits
SUPFAMiSSF57362 SSF57362, 3 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 3 hits
PS50279 BPTI_KUNITZ_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYTMKKVHA LWVSICLMLN LAPAPLNADS EEDEEYTIIT DTELPPLKLM
60 70 80 90 100
HSFCAFKPDD GPCKAIMKRF FFNIFTRQCE EFIYGGCGGN QNRFESMEEC
110 120 130 140 150
KKVCTRDNVH RIIQTALQQE KPDFCFLEED PGICRGYITR YFYNNQSKQC
160 170 180 190 200
ERFKYGGCLG NMNNFETLEE CKNTCEDGLN GFQVDNYGTQ LNAVNNSQTP
210 220 230 240 250
QSTKVPSFFE FHGPSWCLAP ADRGLCRANE NRFYYNSVIG KCRPFKYSGC
260 270 280 290 300
GGNENNFTSK RECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEVF

VKNM
Length:304
Mass (Da):35,085
Last modified:November 1, 1996 - v1
Checksum:i56E13B3FF16282B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73337 mRNA Translation: AAB31955.1
PIRiJC2264
RefSeqiNP_001181951.1, NM_001195022.1
UniGeneiMmu.2687

Genome annotation databases

GeneIDi613026
KEGGimcc:613026

Similar proteinsi

Entry informationi

Entry nameiTFPI1_MACMU
AccessioniPrimary (citable) accession number: Q28864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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