SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q28838

- ADA2A_BOVIN

UniProt

Q28838 - ADA2A_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Alpha-2A adrenergic receptor
Gene
ADRA2A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 By similarity.

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. platelet activation Source: InterPro
  2. regulation of smooth muscle contraction Source: InterPro
  3. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Alpha-2D adrenergic receptor
Gene namesi
Name:ADRA2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Extracellular By similarity
Add
BLAST
Transmembranei34 – 5926Helical; Name=1; By similarity
Add
BLAST
Topological domaini60 – 7011Cytoplasmic By similarity
Add
BLAST
Transmembranei71 – 9626Helical; Name=2; By similarity
Add
BLAST
Topological domaini97 – 10610Extracellular By similarity
Transmembranei107 – 12923Helical; Name=3; By similarity
Add
BLAST
Topological domaini130 – 14920Cytoplasmic By similarity
Add
BLAST
Transmembranei150 – 17324Helical; Name=4; By similarity
Add
BLAST
Topological domaini174 – 19219Extracellular By similarity
Add
BLAST
Transmembranei193 – 21725Helical; Name=5; By similarity
Add
BLAST
Topological domaini218 – 376159Cytoplasmic By similarity
Add
BLAST
Transmembranei377 – 40125Helical; Name=6; By similarity
Add
BLAST
Topological domaini402 – 41110Extracellular By similarity
Transmembranei412 – 43221Helical; Name=7; By similarity
Add
BLAST
Topological domaini433 – 45220Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Alpha-2A adrenergic receptor
PRO_0000069078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 188 By similarity
Lipidationi444 – 4441S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ28838.

Expressioni

Tissue specificityi

Retina, brain and olfactory lobe.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ28838.
SMRiQ28838. Positions 118-149.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ28838.
KOiK04138.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28838-1 [UniParc]FASTAAdd to Basket

« Hide

MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG    50
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 100
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 150
KAIIVTVWVI SAVISFPPLI SFEKKRGRSG QPSAEPRCEI NDQKWYVISS 200
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDATA AELPGSAERR 250
PNGLGPERGG VGPVGAEVES LQVQLNGAPG EPAPAGAGAD ALDLEESSSS 300
EHAERPPGSR RSERGPRAKG KARASQVKPG DSLPRRGPGA TGLGAPTAGP 350
AEERSGGGAK ASRWRGRQNR EKRFTFVLAV VIGVFVVCWF PFFFTYTLTA 400
IGCPVPPTLF KFFFWFGYCN SSLNPVIYTI FNHDFRRAFK KILCRGDRKR 450
IV 452
Length:452
Mass (Da):49,252
Last modified:May 1, 1999 - v2
Checksum:iF10C1DD2860CD6F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79030 Genomic DNA. Translation: AAC24958.1.
S66295 mRNA. Translation: AAB28450.1.
PIRiI46958.
RefSeqiNP_776924.1. NM_174499.1.
UniGeneiBt.88699.

Genome annotation databases

GeneIDi282135.
KEGGibta:282135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79030 Genomic DNA. Translation: AAC24958.1 .
S66295 mRNA. Translation: AAB28450.1 .
PIRi I46958.
RefSeqi NP_776924.1. NM_174499.1.
UniGenei Bt.88699.

3D structure databases

ProteinModelPortali Q28838.
SMRi Q28838. Positions 118-149.
ModBasei Search...

Chemistry

BindingDBi Q28838.
ChEMBLi CHEMBL2111420.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q28838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282135.
KEGGi bta:282135.

Organism-specific databases

CTDi 150.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q28838.
KOi K04138.

Miscellaneous databases

NextBioi 20805970.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor."
    Venkataraman V., Duda T., Sharma R.K.
    Mol. Cell. Biochem. 177:113-123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular determinants of the alpha-2D adrenergic receptor subtype."
    Blaxall H.S., Heck D.A., Bylund D.B.
    Life Sci. 53:PL255-PL259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-210.

Entry informationi

Entry nameiADA2A_BOVIN
AccessioniPrimary (citable) accession number: Q28838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
Error
SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

500 Internal Server Error

The server was not able to handle your request.

If this error occurs repeatedly, please contact us and indicate the page you were trying to access.