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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Alpha-2D adrenergic receptor
Gene namesi
Name:ADRA2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularBy similarityAdd
BLAST
Transmembranei34 – 5926Helical; Name=1By similarityAdd
BLAST
Topological domaini60 – 7011CytoplasmicBy similarityAdd
BLAST
Transmembranei71 – 9626Helical; Name=2By similarityAdd
BLAST
Topological domaini97 – 10610ExtracellularBy similarity
Transmembranei107 – 12923Helical; Name=3By similarityAdd
BLAST
Topological domaini130 – 14920CytoplasmicBy similarityAdd
BLAST
Transmembranei150 – 17324Helical; Name=4By similarityAdd
BLAST
Topological domaini174 – 19219ExtracellularBy similarityAdd
BLAST
Transmembranei193 – 21725Helical; Name=5By similarityAdd
BLAST
Topological domaini218 – 376159CytoplasmicBy similarityAdd
BLAST
Transmembranei377 – 40125Helical; Name=6By similarityAdd
BLAST
Topological domaini402 – 41110ExtracellularBy similarity
Transmembranei412 – 43221Helical; Name=7By similarityAdd
BLAST
Topological domaini433 – 45220CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Alpha-2A adrenergic receptorPRO_0000069078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Lipidationi444 – 4441S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ28838.

Expressioni

Tissue specificityi

Retina, brain and olfactory lobe.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ28838.
SMRiQ28838. Positions 118-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ28838.
KOiK04138.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SFEKKRGRSG QPSAEPRCEI NDQKWYVISS
210 220 230 240 250
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDATA AELPGSAERR
260 270 280 290 300
PNGLGPERGG VGPVGAEVES LQVQLNGAPG EPAPAGAGAD ALDLEESSSS
310 320 330 340 350
EHAERPPGSR RSERGPRAKG KARASQVKPG DSLPRRGPGA TGLGAPTAGP
360 370 380 390 400
AEERSGGGAK ASRWRGRQNR EKRFTFVLAV VIGVFVVCWF PFFFTYTLTA
410 420 430 440 450
IGCPVPPTLF KFFFWFGYCN SSLNPVIYTI FNHDFRRAFK KILCRGDRKR

IV
Length:452
Mass (Da):49,252
Last modified:May 1, 1999 - v2
Checksum:iF10C1DD2860CD6F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79030 Genomic DNA. Translation: AAC24958.1.
S66295 mRNA. Translation: AAB28450.1.
PIRiI46958.
RefSeqiNP_776924.1. NM_174499.1.
UniGeneiBt.88699.

Genome annotation databases

GeneIDi282135.
KEGGibta:282135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79030 Genomic DNA. Translation: AAC24958.1.
S66295 mRNA. Translation: AAB28450.1.
PIRiI46958.
RefSeqiNP_776924.1. NM_174499.1.
UniGeneiBt.88699.

3D structure databases

ProteinModelPortaliQ28838.
SMRiQ28838. Positions 118-149.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ28838.
ChEMBLiCHEMBL4744.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ28838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282135.
KEGGibta:282135.

Organism-specific databases

CTDi150.

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ28838.
KOiK04138.

Miscellaneous databases

NextBioi20805970.
PROiQ28838.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor."
    Venkataraman V., Duda T., Sharma R.K.
    Mol. Cell. Biochem. 177:113-123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular determinants of the alpha-2D adrenergic receptor subtype."
    Blaxall H.S., Heck D.A., Bylund D.B.
    Life Sci. 53:PL255-PL259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-210.

Entry informationi

Entry nameiADA2A_BOVIN
AccessioniPrimary (citable) accession number: Q28838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.