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Q28838

- ADA2A_BOVIN

UniProt

Q28838 - ADA2A_BOVIN

Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 May 1999)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 By similarity.By similarity

    GO - Molecular functioni

    1. alpha2-adrenergic receptor activity Source: InterPro

    GO - Biological processi

    1. platelet activation Source: InterPro
    2. regulation of smooth muscle contraction Source: InterPro
    3. regulation of vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2A adrenergic receptor
    Alternative name(s):
    Alpha-2A adrenoreceptor
    Short name:
    Alpha-2A adrenoceptor
    Short name:
    Alpha-2AAR
    Alpha-2D adrenergic receptor
    Gene namesi
    Name:ADRA2A
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Alpha-2A adrenergic receptorPRO_0000069078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
    Lipidationi444 – 4441S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ28838.

    Expressioni

    Tissue specificityi

    Retina, brain and olfactory lobe.

    Interactioni

    Subunit structurei

    Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ28838.
    SMRiQ28838. Positions 118-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularBy similarityAdd
    BLAST
    Topological domaini60 – 7011CytoplasmicBy similarityAdd
    BLAST
    Topological domaini97 – 10610ExtracellularBy similarity
    Topological domaini130 – 14920CytoplasmicBy similarityAdd
    BLAST
    Topological domaini174 – 19219ExtracellularBy similarityAdd
    BLAST
    Topological domaini218 – 376159CytoplasmicBy similarityAdd
    BLAST
    Topological domaini402 – 41110ExtracellularBy similarity
    Topological domaini433 – 45220CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5926Helical; Name=1By similarityAdd
    BLAST
    Transmembranei71 – 9626Helical; Name=2By similarityAdd
    BLAST
    Transmembranei107 – 12923Helical; Name=3By similarityAdd
    BLAST
    Transmembranei150 – 17324Helical; Name=4By similarityAdd
    BLAST
    Transmembranei193 – 21725Helical; Name=5By similarityAdd
    BLAST
    Transmembranei377 – 40125Helical; Name=6By similarityAdd
    BLAST
    Transmembranei412 – 43221Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ28838.
    KOiK04138.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28838-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG    50
    NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 100
    FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 150
    KAIIVTVWVI SAVISFPPLI SFEKKRGRSG QPSAEPRCEI NDQKWYVISS 200
    SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDATA AELPGSAERR 250
    PNGLGPERGG VGPVGAEVES LQVQLNGAPG EPAPAGAGAD ALDLEESSSS 300
    EHAERPPGSR RSERGPRAKG KARASQVKPG DSLPRRGPGA TGLGAPTAGP 350
    AEERSGGGAK ASRWRGRQNR EKRFTFVLAV VIGVFVVCWF PFFFTYTLTA 400
    IGCPVPPTLF KFFFWFGYCN SSLNPVIYTI FNHDFRRAFK KILCRGDRKR 450
    IV 452
    Length:452
    Mass (Da):49,252
    Last modified:May 1, 1999 - v2
    Checksum:iF10C1DD2860CD6F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79030 Genomic DNA. Translation: AAC24958.1.
    S66295 mRNA. Translation: AAB28450.1.
    PIRiI46958.
    RefSeqiNP_776924.1. NM_174499.1.
    UniGeneiBt.88699.

    Genome annotation databases

    GeneIDi282135.
    KEGGibta:282135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79030 Genomic DNA. Translation: AAC24958.1 .
    S66295 mRNA. Translation: AAB28450.1 .
    PIRi I46958.
    RefSeqi NP_776924.1. NM_174499.1.
    UniGenei Bt.88699.

    3D structure databases

    ProteinModelPortali Q28838.
    SMRi Q28838. Positions 118-149.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q28838.
    ChEMBLi CHEMBL2111420.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q28838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282135.
    KEGGi bta:282135.

    Organism-specific databases

    CTDi 150.

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q28838.
    KOi K04138.

    Miscellaneous databases

    NextBioi 20805970.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor."
      Venkataraman V., Duda T., Sharma R.K.
      Mol. Cell. Biochem. 177:113-123(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular determinants of the alpha-2D adrenergic receptor subtype."
      Blaxall H.S., Heck D.A., Bylund D.B.
      Life Sci. 53:PL255-PL259(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-210.

    Entry informationi

    Entry nameiADA2A_BOVIN
    AccessioniPrimary (citable) accession number: Q28838
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3