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Q28838

- ADA2A_BOVIN

UniProt

Q28838 - ADA2A_BOVIN

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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).By similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: InterPro

GO - Biological processi

  1. platelet activation Source: InterPro
  2. regulation of smooth muscle contraction Source: InterPro
  3. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Alpha-2D adrenergic receptor
Gene namesi
Name:ADRA2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Alpha-2A adrenergic receptorPRO_0000069078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Lipidationi444 – 4441S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ28838.

Expressioni

Tissue specificityi

Retina, brain and olfactory lobe.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ28838.
SMRiQ28838. Positions 118-149.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularBy similarityAdd
BLAST
Topological domaini60 – 7011CytoplasmicBy similarityAdd
BLAST
Topological domaini97 – 10610ExtracellularBy similarity
Topological domaini130 – 14920CytoplasmicBy similarityAdd
BLAST
Topological domaini174 – 19219ExtracellularBy similarityAdd
BLAST
Topological domaini218 – 376159CytoplasmicBy similarityAdd
BLAST
Topological domaini402 – 41110ExtracellularBy similarity
Topological domaini433 – 45220CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5926Helical; Name=1By similarityAdd
BLAST
Transmembranei71 – 9626Helical; Name=2By similarityAdd
BLAST
Transmembranei107 – 12923Helical; Name=3By similarityAdd
BLAST
Transmembranei150 – 17324Helical; Name=4By similarityAdd
BLAST
Transmembranei193 – 21725Helical; Name=5By similarityAdd
BLAST
Transmembranei377 – 40125Helical; Name=6By similarityAdd
BLAST
Transmembranei412 – 43221Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ28838.
KOiK04138.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28838-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SFEKKRGRSG QPSAEPRCEI NDQKWYVISS
210 220 230 240 250
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDATA AELPGSAERR
260 270 280 290 300
PNGLGPERGG VGPVGAEVES LQVQLNGAPG EPAPAGAGAD ALDLEESSSS
310 320 330 340 350
EHAERPPGSR RSERGPRAKG KARASQVKPG DSLPRRGPGA TGLGAPTAGP
360 370 380 390 400
AEERSGGGAK ASRWRGRQNR EKRFTFVLAV VIGVFVVCWF PFFFTYTLTA
410 420 430 440 450
IGCPVPPTLF KFFFWFGYCN SSLNPVIYTI FNHDFRRAFK KILCRGDRKR

IV
Length:452
Mass (Da):49,252
Last modified:May 1, 1999 - v2
Checksum:iF10C1DD2860CD6F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79030 Genomic DNA. Translation: AAC24958.1.
S66295 mRNA. Translation: AAB28450.1.
PIRiI46958.
RefSeqiNP_776924.1. NM_174499.1.
UniGeneiBt.88699.

Genome annotation databases

GeneIDi282135.
KEGGibta:282135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79030 Genomic DNA. Translation: AAC24958.1 .
S66295 mRNA. Translation: AAB28450.1 .
PIRi I46958.
RefSeqi NP_776924.1. NM_174499.1.
UniGenei Bt.88699.

3D structure databases

ProteinModelPortali Q28838.
SMRi Q28838. Positions 118-149.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q28838.
ChEMBLi CHEMBL4744.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q28838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282135.
KEGGi bta:282135.

Organism-specific databases

CTDi 150.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q28838.
KOi K04138.

Miscellaneous databases

NextBioi 20805970.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor."
    Venkataraman V., Duda T., Sharma R.K.
    Mol. Cell. Biochem. 177:113-123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular determinants of the alpha-2D adrenergic receptor subtype."
    Blaxall H.S., Heck D.A., Bylund D.B.
    Life Sci. 53:PL255-PL259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-210.

Entry informationi

Entry nameiADA2A_BOVIN
AccessioniPrimary (citable) accession number: Q28838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3