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Q28833

- VWF_PIG

UniProt

Q28833 - VWF_PIG

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Protein
von Willebrand factor
Gene
VWF, F8VWF
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma By similarity.

GO - Molecular functioni

  1. chaperone binding Source: UniProtKB
  2. collagen binding Source: UniProtKB
  3. glycoprotein binding Source: UniProtKB
  4. immunoglobulin binding Source: UniProtKB
  5. integrin binding Source: UniProtKB
  6. protease binding Source: UniProtKB
  7. protein N-terminus binding Source: UniProtKB
  8. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: UniProtKB
  2. cell adhesion Source: UniProtKB
  3. cell-substrate adhesion Source: UniProtKB
  4. hemostasis Source: UniProtKB
  5. platelet activation Source: UniProtKB
  6. protein homooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Protein family/group databases

MEROPSiI08.954.

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Gene namesi
Name:VWF
Synonyms:F8VWF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity. Secretedextracellular spaceextracellular matrix By similarity
Note: Localized to storage granules By similarity.

GO - Cellular componenti

  1. Weibel-Palade body Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. extracellular matrix Source: UniProtKB
  4. extracellular region Source: UniProtKB
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei‹1 – 437›437 By similarity
PRO_0000022686Add
BLAST
Chaini438 – 24822045von Willebrand factor
PRO_0000022687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2480 By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi441 ↔ 482 By similarity
Disulfide bondi450 ↔ 478 By similarity
Disulfide bondi484 ↔ 495 By similarity
Disulfide bondi541 ↔ 670 By similarity
Disulfide bondi563 ↔ 705 By similarity
Disulfide bondi572 ↔ 667 By similarity
Disulfide bondi588 ↔ 595 By similarity
Disulfide bondi734 ↔ 758 By similarity
Disulfide bondi745 ↔ 785 By similarity
Disulfide bondi763 ↔ 765 By similarity
Disulfide bondi800 ↔ 804 By similarity
Disulfide bondi823 ↔ 843 By similarity
Disulfide bondi827 ↔ 839 By similarity
Disulfide bondi870 ↔ 873 By similarity
Glycosylationi905 – 9051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi908 ↔ 911 By similarity
Disulfide bondi942 ↔ 1128 By similarity
Glycosylationi1184 – 11841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1243 – 12431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1338 ↔ 1339 By similarity
Disulfide bondi1355 ↔ 1541 By similarity
Cross-linki1389 – 1389Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Disulfide bondi1548 ↔ 1573 By similarity
Disulfide bondi1568 ↔ 1609Or C-1568 with C-1611 By similarity
Disulfide bondi1596 ↔ 1757 By similarity
Disulfide bondi1619 ↔ 1754 By similarity
Glycosylationi1640 – 16401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1641 ↔ 1792 By similarity
Disulfide bondi1662 ↔ 1670 By similarity
Glycosylationi1892 – 18921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1959 – 19591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2026 – 20261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2069 – 20691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2215 – 22151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2254 – 22541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2393 ↔ 2443 By similarity
Disulfide bondi2408 ↔ 2457 By similarity
Disulfide bondi2419 ↔ 2473 By similarity
Disulfide bondi2423 ↔ 2475 By similarity
Glycosylationi2459 – 24591N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds By similarity.
N- and O-glycosylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ28833.
PRIDEiQ28833.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Multimeric. Interacts with F8 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ28833.
SMRiQ28833. Positions 931-1138, 1353-1542.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 272212VWFD 1
Add
BLAST
Domaini326 – 38156TIL 1
Add
BLAST
Domaini450 – 50152TIL 2
Add
BLAST
Domaini540 – 748209VWFD 2
Add
BLAST
Domaini820 – 87051TIL 3
Add
BLAST
Domaini947 – 1127181VWFA 1
Add
BLAST
Domaini1167 – 1334168VWFA 2
Add
BLAST
Domaini1360 – 1540181VWFA 3
Add
BLAST
Domaini1618 – 1822205VWFD 3
Add
BLAST
Domaini1924 – 199774VWFC 1
Add
BLAST
Domaini2098 – 216467VWFC 2
Add
BLAST
Domaini2249 – 231466VWFC 3
Add
BLAST
Domaini2393 – 248189CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni438 – 46124Amino-terminal
Add
BLAST
Regioni462 – 50746E1
Add
BLAST
Regioni500 – 52728CX
Add
BLAST
Regioni1885 – 193046E2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2176 – 21783Cell attachment site Reviewed prediction

Domaini

The propeptide is required for multimerization of vWF and for its targeting to storage granules By similarity.

Sequence similaritiesi

Contains 3 VWFA domains.
Contains 3 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG004380.

Family and domain databases

Gene3Di3.40.50.410. 3 hits.
InterProiIPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR002035. VWF_A.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 4 hits.
PF00092. VWA. 3 hits.
PF00093. VWC. 2 hits.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00181. EGF. 1 hit.
SM00327. VWA. 3 hits.
SM00214. VWC. 5 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 3 hits.
SSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50234. VWFA. 3 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28833-1 [UniParc]FASTAAdd to Basket

« Hide

DGCSCPEGQL LDDGRCVESA ECSCVHSGKR YPPGASLSRD CNTCICRNSL     50
WVCSNEDCPG ECLVTGQSHF KSFDNRHFTF SGVCQYLLAR DCQDHTFSVI 100
IETVQCADDP DAVCTRSVTV RLPSPHNSLV KLKHGGGVAM DGWDVQIPFL 150
QGDLRIQHTV MASVHLSYGE DLQIDWDGRG RLLVKLSPVY AGRTCGLCGN 200
YNGNQGDDFL TPAGLVEPLV EHFGNAWKLH GDCEDLRKQP TDPCSFNPRL 250
TRFAEEACAI LTSPKFQACH DAVGPLPYLQ NCHYDVCSCS DGRDCLCDAV 300
ATYAAACARR GVHIGWREPG FCALSCPPGQ VYLQCGTPCN LTCRSLSYPD 350
EECAEDCLEG CFCPPGLYLD GSGDCVPKAQ CPCYHDGEIF QPEDIFSDHH 400
TMCYCEDGFM HCSRAGAPGS LQPEVVLSSP LSHRSKRSLS CRPPMVKLVC 450
PADNPRAEGL ECAKTCQNYD LECVSTGCVS GCLCPPGMVR HENRCVALQR 500
CPCFHQGREY APGETVKVDC NTCVCRDRKW SCTDHVCDAS CSALGLAHYL 550
TFDGLKYLFP GECQYVLVQD YCGSNPGTFR ILLGNEGCGY PSLKCRKRVT 600
ILVDGGEIEL FDGEVMVKKP LKDETHFEVV ESGRFITVLL GSGLSVVWDR 650
HLGISVFLKQ TYQEQVCGLC GNFDGVQNND LTGSSLQVEE DPVDFGNSWK 700
VSPQCADTRK VPLDTSPATC HNNVMKQTMV DSSCRILTSD IFQDCNKLVD 750
PEPYLDVCIY DTCSCESIGD CACFCDTIAA YARVCAQHGK VVTWRTATLC 800
PQNCEERNLR EDGYQCEWRY NSCAPACPVT CQHPEPLACP VSCVEGCHAH 850
CPPGKILDEL LQTCVSPEDC PVCEAAGRRL APGKKIILNP RDPAHCQICH 900
CDGVNLTCEA CAEPVPPTEG PVSPTTPYEE DTPEPPLHDF FCSKLLDLVF 950
LLDGSDKLSE ADFEALKVFV VGMMEHLHIS QKHIRVAVVE YHDGPHAYIS 1000
LQDRKRPSEL RRIASQVKYA GSEVASISEV LKYTLFQIFG RVDRPEASRI 1050
ALLLMASQEP RRLAQNLARY LQGLKKKKVT VIPVGIGPHV SLKQIRLIEK 1100
QAPENKAFVV SGVDELEQRK NEIISYLCDL APEVPAPTRR PLVAQVTVAP 1150
ELPGVSTLEP KKRMALDVVF VLEGSDKVGE ANFNRSTEFV EEVIRRMDVG 1200
RDSVHVTVLQ YSYVVAVEHS FREAQSKGEV LQRVREIRFQ GGNRTNTGLA 1250
LQYLSEHSFS ASQGDREEAP NLVYMVTGNP ASDEIKRMPG DIQVVPIGVG 1300
PDVDMQELER LSWPNAPIFI QDFETLPREA PDLVLQRCCS GEGPHLPTQA 1350
PVPDCSQPLG VVLLLDGSSS LPASYFDEMK SFTKAFISKA NIGPQLTQVS 1400
VLQYGSITTI DLPWNMPLEK AHLRGLVDLM QREGGPSQIG DALGFAVRYV 1450
MSQVHGARPE ASKAVVIVVT DTSTDSVDAA AAAARSNRVA VFPIGIGDRY 1500
DEAQLRTLAG PGASSNVVKL QRIEDLPTLV TLGNSFLHKL CSGFVRVCID 1550
EDGSERKPGD VWTLPDQCHT VTCLPDGQTL LKSHRVNCDQ GLQPSCPSNQ 1600
PPIRVEEACG CRWTCPCVCT GSSTRHIVTF DGQNFKLMGN CSYVLFHNKE 1650
QDLEVILHNG ACGAGARQAC MKSIEVKHNG LSVELHRDME VVVNGRQVSV 1700
PYVGGNMEVG IYGTIMYEVR FNHLGHILTF TPQNNEFQLQ LSPKTFASKM 1750
YGLCGICDEN GANDFMLRDG TVTTDWKTMV QEWAVQQPGQ MCQPVPKEQC 1800
PVSGGYQCQV LLSALFAECH KVLAPAAYFA ICQQDSCHQE QVCEAVASYA 1850
HLCRTKGVCV DWRTPDFCAV SCPPSLVYNH CEHGCPRHCE GNSSSCGDHP 1900
SEGCFCPPHQ VMLGSSCVPE EACTQCVDDD GIRHQFLETW VPDHQPCQIC 1950
TCLSGRRVNC TLQPCPTARA PACGLCEVAR LRQEAHQCCP EYECVCDLVS 2000
CDLPPVPHCE GGLQPTLTNP GECRPNFTCA CRKEECPRGP LPSCPPHRTP 2050
ALRKTQCCDE YECACNCVNT TLSCPLGYLA STVTNDCGCT TTTCLPDKVC 2100
VHRGTVYPVG QFWEEGCDVC TCTDLEDAVM GLRVAQCAQK PCEDSCRPGF 2150
TYVLHEGECC GKCLPSACKV VIGSFRGDSV SYWKSVGSHW ASPENPCLIN 2200
ECVRVKEEVF VQQRNVSCPM LDVPTCPVGF QLSCKTSGCC PTCRCEPVEA 2250
CLLNGTIIGA GESLMIDVCT TCRCMLQEGV VFGFKLECKK TTCEACPLGY 2300
KEEKMPGECC GRCLPTACTI QLRGGQIMTL KRDETLQDGC DSHFCRVNER 2350
GEYIWEKRIT GCPPFDQHKC LAAGGKIMKI PGTCCDTCEE PECKDMTARL 2400
QYVKVGNCRS EEEVDIHYCQ GKCTSKAVYS IDTEDVEDQC ACCSPTRTEP 2450
MQVPLRCTNG STIYHEVLNA IQCKCSPRKC SK 2482
Length:2,482
Mass (Da):272,397
Last modified:May 1, 1999 - v2
Checksum:iD499B7DDFBBCAEDD
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052036 mRNA. Translation: AAC06229.1.
S64541 mRNA. Translation: AAB27829.2.
PIRiPN0563.
UniGeneiSsc.978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052036 mRNA. Translation: AAC06229.1 .
S64541 mRNA. Translation: AAB27829.2 .
PIRi PN0563.
UniGenei Ssc.978.

3D structure databases

ProteinModelPortali Q28833.
SMRi Q28833. Positions 931-1138, 1353-1542.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I08.954.

Proteomic databases

PaxDbi Q28833.
PRIDEi Q28833.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG004380.

Family and domain databases

Gene3Di 3.40.50.410. 3 hits.
InterProi IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR002035. VWF_A.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 4 hits.
PF00092. VWA. 3 hits.
PF00093. VWC. 2 hits.
PF00094. VWD. 3 hits.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00181. EGF. 1 hit.
SM00327. VWA. 3 hits.
SM00214. VWC. 5 hits.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 3 hits.
SSF57567. SSF57567. 4 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50234. VWFA. 3 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Seaman W.T., Read M.S., Bellinger D.A., Nichols T.C.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure of the factor VIII binding domain of human, porcine and rabbit von Willebrand factor."
    Lavergne J.-M., Piao Y.C., Ferreira V., Kerbiriou-Nabias D., Bahnak B.R., Meyer D.
    Biochem. Biophys. Res. Commun. 194:1019-1024(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 397-553.
  3. "von Willebrand factor, platelets and endothelial cell interactions."
    Ruggeri Z.M.
    J. Thromb. Haemost. 1:1335-1342(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiVWF_PIG
AccessioniPrimary (citable) accession number: Q28833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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