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Reviewed, UniProtKB/Swiss-Prot Q28827 (CP11A_RABIT)

Last modified October 13, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cholesterol side-chain cleavage enzyme, mitochondrial
    EC=1.14.15.6
Alternative name(s):
    Cytochrome P450 11A1
    CYPXIA1
    P450(scc)
    Cholesterol desmolase
Gene names
Name: CYP11A1
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length445 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

Catalytic activity

Cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; C21-steroid hormone metabolism.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide‹1 – 36›36Mitochondrion By similarity
Chain37 – ›445›409Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000003589

Experimental info

Non-terminal residue11
Non-terminal residue4451

Sequences

Sequence LengthMass (Da)Tools
Q28827-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B6080DFFB028C8CA

FASTA44551,016
        10         20         30         40         50         60 
RGLPSRSVFL RGCQASLSTA QERLGHPGVP TREGVRVATR SPRPYHEIPS PGDNGWLNLY 

        70         80         90        100        110        120 
HLAEEKGTHR VHYRHVQNFQ KYGPIYRENL GNVESVYIMD PEDVALLFNS EGPQPERFLI 

       130        140        150        160        170        180 
PPWVAYHEYY RRPVGVLLKK AQGWKRDRVA LNQEVMAPDA IKNFVPLLEA VSQAFVRMLH 

       190        200        210        220        230        240 
GRVQQGVFSG DISDDLFRFA FESMTNIMFG ERLGMLEETV DPEAHEFIDA VYQMFHTSVP 

       250        260        270        280        290        300 
MLSLPPSLFR LFRTRTWRDH VAAWDVIFTN ADKYTQSFYW DLRQKQDLGG SYRGILYSLL 

       310        320        330        340        350        360 
GTSKLSFEDI KANVTEMLAG SVDTTSMTLQ WHLYEMGAAL GMQEMLRAEV LAARRQAQGD 

       370        380        390        400        410        420 
MTAMLQSVPL LKASIKETLR LHPISVTLQR YLVNDLVLQD YMIPAKTLVQ VANYGMGREP 

       430        440 
SFFANPEKFD PPRWLDKDKN ATHFR 

« Hide

References

[1]"Inherited congenital adrenal hyperplasia in the rabbit is caused by a deletion in the gene encoding cytochrome P450 cholesterol side-chain cleavage enzyme."
Yang X., Iwamoto K., Wang M., Artwohl J., Mason J.I., Pang S.
Endocrinology 132:1977-1982(1993) [PubMed: 7682938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

S59219 mRNA. Translation: AAB26372.1.
PIRA49189.

3D structure databases

HSSPHSSP built from PDB template 1SCC based on UniProtKB P00189.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ28827.

Enzyme and pathway databases

BRENDA1.14.15.6. 255.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mit_N.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00408. MITP450.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP11A_RABIT
AccessionPrimary (citable) accession number: Q28827
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 13, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents