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Q28827

- CP11A_RABIT

UniProt

Q28827 - CP11A_RABIT

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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

CYP11A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactori

Heme group.By similarity

Pathwayi

GO - Molecular functioni

  1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. C21-steroid hormone biosynthetic process Source: UniProtKB
  2. cholesterol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene namesi
Name:CYP11A1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei‹1 – 36›36MitochondrionBy similarityAdd
BLAST
Chaini37 – ›445›409Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003589Add
BLAST

Interactioni

Subunit structurei

Interacts with FDX1/adrenodoxin.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023976.

Structurei

3D structure databases

ProteinModelPortaliQ28827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000013161.
HOVERGENiHBG051098.
InParanoidiQ28827.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28827-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RGLPSRSVFL RGCQASLSTA QERLGHPGVP TREGVRVATR SPRPYHEIPS
60 70 80 90 100
PGDNGWLNLY HLAEEKGTHR VHYRHVQNFQ KYGPIYRENL GNVESVYIMD
110 120 130 140 150
PEDVALLFNS EGPQPERFLI PPWVAYHEYY RRPVGVLLKK AQGWKRDRVA
160 170 180 190 200
LNQEVMAPDA IKNFVPLLEA VSQAFVRMLH GRVQQGVFSG DISDDLFRFA
210 220 230 240 250
FESMTNIMFG ERLGMLEETV DPEAHEFIDA VYQMFHTSVP MLSLPPSLFR
260 270 280 290 300
LFRTRTWRDH VAAWDVIFTN ADKYTQSFYW DLRQKQDLGG SYRGILYSLL
310 320 330 340 350
GTSKLSFEDI KANVTEMLAG SVDTTSMTLQ WHLYEMGAAL GMQEMLRAEV
360 370 380 390 400
LAARRQAQGD MTAMLQSVPL LKASIKETLR LHPISVTLQR YLVNDLVLQD
410 420 430 440
YMIPAKTLVQ VANYGMGREP SFFANPEKFD PPRWLDKDKN ATHFR
Length:445
Mass (Da):51,016
Last modified:November 1, 1996 - v1
Checksum:iB6080DFFB028C8CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei445 – 4451

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S59219 mRNA. Translation: AAB26372.1.
PIRiA49189.
UniGeneiOcu.3315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S59219 mRNA. Translation: AAB26372.1 .
PIRi A49189.
UniGenei Ocu.3315.

3D structure databases

ProteinModelPortali Q28827.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000023976.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000013161.
HOVERGENi HBG051098.
InParanoidi Q28827.

Enzyme and pathway databases

UniPathwayi UPA00229 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00408. MITP450.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Inherited congenital adrenal hyperplasia in the rabbit is caused by a deletion in the gene encoding cytochrome P450 cholesterol side-chain cleavage enzyme."
    Yang X., Iwamoto K., Wang M., Artwohl J., Mason J.I., Pang S.
    Endocrinology 132:1977-1982(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP11A_RABIT
AccessioniPrimary (citable) accession number: Q28827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3