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Q28811

- PHR_POTTR

UniProt

Q28811 - PHR_POTTR

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Protein
Deoxyribodipyrimidine photo-lyase
Gene
PHR
Organism
Potorous tridactylus (Potoroo)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.

Catalytic activityi

Cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei322 – 3221DNA By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi468 – 4703FAD By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. deoxyribodipyrimidine photo-lyase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Chromophore, DNA-binding, FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribodipyrimidine photo-lyase (EC:4.1.99.3)
Alternative name(s):
DNA photolyase
Photoreactivating enzyme
Gene namesi
Name:PHR
OrganismiPotorous tridactylus (Potoroo)
Taxonomic identifieri9310 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaPotoroidaePotorous

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Deoxyribodipyrimidine photo-lyase
PRO_0000085120Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ28811.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 229133Photolyase/cryptochrome alpha/beta
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3769Interaction with DNA By similarity
Regioni442 – 4432Interaction with DNA By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008186.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR008148. DNA_photolyase_2.
IPR006050. DNA_photolyase_N.
IPR005101. Photolyase_FAD-bd/Cryptochr_C.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10211. PTHR10211. 1 hit.
PfamiPF00875. DNA_photolyase. 1 hit.
PF03441. FAD_binding_7. 1 hit.
[Graphical view]
SUPFAMiSSF48173. SSF48173. 1 hit.
SSF52425. SSF52425. 1 hit.
TIGRFAMsiTIGR00591. phr2. 1 hit.
PROSITEiPS01083. DNA_PHOTOLYASES_2_1. 1 hit.
PS01084. DNA_PHOTOLYASES_2_2. 1 hit.
PS51645. PHR_CRY_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28811-1 [UniParc]FASTAAdd to Basket

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MDSKKRSHST GGEAENMESQ ESKAKRKPLQ KHQFSKSNVV QKEEKDKTEG    50
EEKGAEGLQE VVRQSRLRTA PSVLEFRFNK QRVRLISQDC HLQDQSQAFV 100
YWMSRDQRVQ DNWAFLYAQR LALKQKLPLH VCFCLAPCFL GATIRHYDFM 150
LRGLEEVAEE CEKLCIPFHL LLGLPKDVLP AFVQTHGIGG IVTDFSPLLH 200
HTQWVKDVQD ALPRQVPFVQ VDAHNIVPCW VASDKQEYGA RTIRHKIHDR 250
LPHFLTEFPP VICHPYTSNV QAEPVDWNGC RAGLQVDRSV KEVSWAKPGT 300
ASGLTMLQSF IAERLPYFGS DRNNPNKDAL SNLSPWFHFG QVSVQRAILE 350
VQKHRSRYPD SVTNFVEEAV VRRELADNFC FYNKNYDKLE GAYDWAQTTL 400
RLHAKDKRPH LYSLEQLESG KTHDPLWNAA QMQTVKEGKM HGFLRMYWAK 450
KILEWTRSPE EALEFAIYLN DRFQLDGWDP NGYVGCMWSI CGIHDQGWAE 500
REIFGKIRYM NYAGCKRKFD VAEFERKISP AD 532
Length:532
Mass (Da):61,631
Last modified:November 1, 1996 - v1
Checksum:i0865B1BFDE7BB25B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26020 mRNA. Translation: BAA05041.1.
PIRiS52046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26020 mRNA. Translation: BAA05041.1 .
PIRi S52046.

3D structure databases

ProteinModelPortali Q28811.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG008186.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
InterProi IPR008148. DNA_photolyase_2.
IPR006050. DNA_photolyase_N.
IPR005101. Photolyase_FAD-bd/Cryptochr_C.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10211. PTHR10211. 1 hit.
Pfami PF00875. DNA_photolyase. 1 hit.
PF03441. FAD_binding_7. 1 hit.
[Graphical view ]
SUPFAMi SSF48173. SSF48173. 1 hit.
SSF52425. SSF52425. 1 hit.
TIGRFAMsi TIGR00591. phr2. 1 hit.
PROSITEi PS01083. DNA_PHOTOLYASES_2_1. 1 hit.
PS01084. DNA_PHOTOLYASES_2_2. 1 hit.
PS51645. PHR_CRY_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new class of DNA photolyases present in various organisms including aplacental mammals."
    Yasui A., Eker A.P., Yasuhira S., Yajima H., Kobayashi T., Takao M., Oikawa A.
    EMBO J. 13:6143-6151(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPHR_POTTR
AccessioniPrimary (citable) accession number: Q28811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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