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Q28811 (PHR_POTTR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyribodipyrimidine photo-lyase

EC=4.1.99.3
Alternative name(s):
DNA photolyase
Photoreactivating enzyme
Gene names
Name:PHR
OrganismPotorous tridactylus (Potoroo)
Taxonomic identifier9310 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaPotoroidaePotorous

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.

Catalytic activity

Cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).

Cofactor

FAD.

Sequence similarities

Belongs to the DNA photolyase class-2 family.

Contains 1 photolyase/cryptochrome alpha/beta domain.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandChromophore
DNA-binding
FAD
Flavoprotein
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

protein-chromophore linkage

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

deoxyribodipyrimidine photo-lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Deoxyribodipyrimidine photo-lyase
PRO_0000085120

Regions

Domain97 – 229133Photolyase/cryptochrome alpha/beta
Nucleotide binding468 – 4703FAD By similarity
Region368 – 3769Interaction with DNA By similarity
Region442 – 4432Interaction with DNA By similarity

Sites

Binding site3221DNA By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28811 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0865B1BFDE7BB25B

FASTA53261,631
        10         20         30         40         50         60 
MDSKKRSHST GGEAENMESQ ESKAKRKPLQ KHQFSKSNVV QKEEKDKTEG EEKGAEGLQE 

        70         80         90        100        110        120 
VVRQSRLRTA PSVLEFRFNK QRVRLISQDC HLQDQSQAFV YWMSRDQRVQ DNWAFLYAQR 

       130        140        150        160        170        180 
LALKQKLPLH VCFCLAPCFL GATIRHYDFM LRGLEEVAEE CEKLCIPFHL LLGLPKDVLP 

       190        200        210        220        230        240 
AFVQTHGIGG IVTDFSPLLH HTQWVKDVQD ALPRQVPFVQ VDAHNIVPCW VASDKQEYGA 

       250        260        270        280        290        300 
RTIRHKIHDR LPHFLTEFPP VICHPYTSNV QAEPVDWNGC RAGLQVDRSV KEVSWAKPGT 

       310        320        330        340        350        360 
ASGLTMLQSF IAERLPYFGS DRNNPNKDAL SNLSPWFHFG QVSVQRAILE VQKHRSRYPD 

       370        380        390        400        410        420 
SVTNFVEEAV VRRELADNFC FYNKNYDKLE GAYDWAQTTL RLHAKDKRPH LYSLEQLESG 

       430        440        450        460        470        480 
KTHDPLWNAA QMQTVKEGKM HGFLRMYWAK KILEWTRSPE EALEFAIYLN DRFQLDGWDP 

       490        500        510        520        530 
NGYVGCMWSI CGIHDQGWAE REIFGKIRYM NYAGCKRKFD VAEFERKISP AD 

« Hide

References

[1]"A new class of DNA photolyases present in various organisms including aplacental mammals."
Yasui A., Eker A.P., Yasuhira S., Yajima H., Kobayashi T., Takao M., Oikawa A.
EMBO J. 13:6143-6151(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26020 mRNA. Translation: BAA05041.1.
PIRS52046.

3D structure databases

ProteinModelPortalQ28811.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008186.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
InterProIPR008148. DNA_photolyase_2.
IPR006050. DNA_photolyase_N.
IPR005101. Photolyase_FAD-bd/Cryptochr_C.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10211. PTHR10211. 1 hit.
PfamPF00875. DNA_photolyase. 1 hit.
PF03441. FAD_binding_7. 1 hit.
[Graphical view]
SUPFAMSSF48173. SSF48173. 1 hit.
SSF52425. SSF52425. 1 hit.
TIGRFAMsTIGR00591. phr2. 1 hit.
PROSITEPS01083. DNA_PHOTOLYASES_2_1. 1 hit.
PS01084. DNA_PHOTOLYASES_2_2. 1 hit.
PS51645. PHR_CRY_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHR_POTTR
AccessionPrimary (citable) accession number: Q28811
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families