Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitoferrin-1

Gene

slc25a37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme.1 Publication

GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: ZFIN

GO - Biological processi

  • embryonic hemopoiesis Source: ZFIN
  • erythrocyte development Source: ZFIN
  • erythrocyte maturation Source: ZFIN
  • iron ion homeostasis Source: UniProtKB-KW
  • iron ion transmembrane transport Source: GOC
  • mitochondrial iron ion transport Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi2.A.29.5.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-1
Alternative name(s):
Mitochondrial iron transporter 1
Protein frascati
Solute carrier family 25 member 37
Gene namesi
Name:slc25a37
Synonyms:frs, mfrn
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-031118-202. slc25a37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5220Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei94 – 11320Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei131 – 15020Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei188 – 20720Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei222 – 24120Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei289 – 30820Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi46 – 461L → R in frs-tq223; induces embryonic hypochronic anemia. 1 Publication
Mutagenesisi61 – 611M → K in frs-tm130; induces embryonic hypochronic anemia. 1 Publication
Mutagenesisi144 – 1441L → H in frs-ij001; induces embryonic hypochronic anemia. 1 Publication
Mutagenesisi158 – 1581R → W in frs-tg180; induces embryonic hypochronic anemia. 1 Publication
Mutagenesisi207 – 2071Y → D in frs-tg221; induces embryonic hypochronic anemia. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Mitoferrin-1PRO_0000235254Add
BLAST

Proteomic databases

PaxDbiQ287T7.

Expressioni

Tissue specificityi

Highly expressed in hematopoietic organs, Expressed in the intermediate cell mass (ICM), a tissue equivalent to the mammalian extraembryonic yolk-sac blood islands. Colocalizes with gata1.1 Publication

Gene expression databases

BgeeiQ287T7.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090636.

Structurei

3D structure databases

ProteinModelPortaliQ287T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 11989Solcar 1Add
BLAST
Repeati129 – 21385Solcar 2Add
BLAST
Repeati220 – 31495Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ287T7.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG77DJ7B.
PhylomeDBiQ287T7.
TreeFamiTF314118.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q287T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRTDAVLA SLEMSEPVKN DEDYESLPAH ASLGTHMTAG AVAGILEHTV
60 70 80 90 100
MYPVDSVKTR MQSLQPDPKA QYRSVYGALK RIVRTEGLLR PLRGLNITVL
110 120 130 140 150
GAGPAHALYF ACYERIKRSL SDVIQNGGNS HIANGVAGSV ATVLHDAVMN
160 170 180 190 200
PAEVVKQRMQ MYNSPYRSLY DCVLMVSRKE GLAAFYRSYS TQLTMNIPFQ
210 220 230 240 250
AVHFITYEFM QEHFNPHRQY RPETHIISGA AAGAVSAAVT TPLDVCKTLL
260 270 280 290 300
NTQENVALSS AHVSGHLSGM VNALRTVYRL GGVPAFFKGI QARVIYQMPS
310 320 330
TAIAWSVYEF FKYFLTQHES HVQEVSHKTS PT
Length:332
Mass (Da):36,711
Last modified:April 4, 2006 - v1
Checksum:i227032AD6BCA8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ112224 mRNA. Translation: ABA33608.1.
DQ112225 mRNA. Translation: ABA33609.1.
RefSeqiNP_001035060.1. NM_001039971.1.
UniGeneiDr.116247.

Genome annotation databases

EnsembliENSDART00000099863; ENSDARP00000090636; ENSDARG00000073743.
GeneIDi387000.
KEGGidre:387000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ112224 mRNA. Translation: ABA33608.1.
DQ112225 mRNA. Translation: ABA33609.1.
RefSeqiNP_001035060.1. NM_001039971.1.
UniGeneiDr.116247.

3D structure databases

ProteinModelPortaliQ287T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090636.

Protein family/group databases

TCDBi2.A.29.5.3. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbiQ287T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000099863; ENSDARP00000090636; ENSDARG00000073743.
GeneIDi387000.
KEGGidre:387000.

Organism-specific databases

CTDi51312.
ZFINiZDB-GENE-031118-202. slc25a37.

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ287T7.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG77DJ7B.
PhylomeDBiQ287T7.
TreeFamiTF314118.

Miscellaneous databases

NextBioi20814113.
PROiQ287T7.

Gene expression databases

BgeeiQ287T7.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LEU-46; MET-61; LEU-144; ARG-158 AND TYR-207.

Entry informationi

Entry nameiMFRN1_DANRE
AccessioniPrimary (citable) accession number: Q287T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 4, 2006
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.