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Protein

Mitoferrin-1

Gene

slc25a37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme.1 Publication

GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: ZFIN

GO - Biological processi

  • embryonic hemopoiesis Source: ZFIN
  • erythrocyte development Source: ZFIN
  • erythrocyte maturation Source: ZFIN
  • iron import into the mitochondrion Source: ZFIN
  • iron ion homeostasis Source: GO_Central
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Protein family/group databases

TCDBi2.A.29.5.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-1
Alternative name(s):
Mitochondrial iron transporter 1
Protein frascati
Solute carrier family 25 member 37
Gene namesi
Name:slc25a37
Synonyms:frs, mfrn
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-031118-202 slc25a37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei94 – 113Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei131 – 150Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei188 – 207Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 241Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei289 – 308Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46L → R in frs-tq223; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi61M → K in frs-tm130; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi144L → H in frs-ij001; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi158R → W in frs-tg180; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi207Y → D in frs-tg221; induces embryonic hypochronic anemia. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352541 – 332Mitoferrin-1Add BLAST332

Proteomic databases

PaxDbiQ287T7

Expressioni

Tissue specificityi

Highly expressed in hematopoietic organs, Expressed in the intermediate cell mass (ICM), a tissue equivalent to the mammalian extraembryonic yolk-sac blood islands. Colocalizes with gata1.1 Publication

Gene expression databases

BgeeiENSDARG00000073743
ExpressionAtlasiQ287T7 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090636

Structurei

3D structure databases

ProteinModelPortaliQ287T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 119Solcar 1Add BLAST89
Repeati129 – 213Solcar 2Add BLAST85
Repeati220 – 314Solcar 3Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760 Eukaryota
ENOG410XNT2 LUCA
GeneTreeiENSGT00550000074721
HOGENOMiHOG000038810
HOVERGENiHBG079464
InParanoidiQ287T7
KOiK15113
OMAiYFLTKHK
OrthoDBiEOG091G0PU8
PhylomeDBiQ287T7
TreeFamiTF314118

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q287T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRTDAVLA SLEMSEPVKN DEDYESLPAH ASLGTHMTAG AVAGILEHTV
60 70 80 90 100
MYPVDSVKTR MQSLQPDPKA QYRSVYGALK RIVRTEGLLR PLRGLNITVL
110 120 130 140 150
GAGPAHALYF ACYERIKRSL SDVIQNGGNS HIANGVAGSV ATVLHDAVMN
160 170 180 190 200
PAEVVKQRMQ MYNSPYRSLY DCVLMVSRKE GLAAFYRSYS TQLTMNIPFQ
210 220 230 240 250
AVHFITYEFM QEHFNPHRQY RPETHIISGA AAGAVSAAVT TPLDVCKTLL
260 270 280 290 300
NTQENVALSS AHVSGHLSGM VNALRTVYRL GGVPAFFKGI QARVIYQMPS
310 320 330
TAIAWSVYEF FKYFLTQHES HVQEVSHKTS PT
Length:332
Mass (Da):36,711
Last modified:April 4, 2006 - v1
Checksum:i227032AD6BCA8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ112224 mRNA Translation: ABA33608.1
DQ112225 mRNA Translation: ABA33609.1
RefSeqiNP_001035060.1, NM_001039971.1
UniGeneiDr.116247

Genome annotation databases

EnsembliENSDART00000099863; ENSDARP00000090636; ENSDARG00000073743
GeneIDi387000
KEGGidre:387000

Similar proteinsi

Entry informationi

Entry nameiMFRN1_DANRE
AccessioniPrimary (citable) accession number: Q287T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 4, 2006
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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