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Protein

Mitoferrin-1

Gene

slc25a37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme.1 Publication

GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: ZFIN

GO - Biological processi

  • embryonic hemopoiesis Source: ZFIN
  • erythrocyte development Source: ZFIN
  • erythrocyte maturation Source: ZFIN
  • iron ion homeostasis Source: UniProtKB-KW
  • mitochondrial iron ion transport Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi2.A.29.5.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-1
Alternative name(s):
Mitochondrial iron transporter 1
Protein frascati
Solute carrier family 25 member 37
Gene namesi
Name:slc25a37
Synonyms:frs, mfrn
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-031118-202. slc25a37.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei94 – 113Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei131 – 150Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei188 – 207Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 241Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei289 – 308Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46L → R in frs-tq223; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi61M → K in frs-tm130; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi144L → H in frs-ij001; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi158R → W in frs-tg180; induces embryonic hypochronic anemia. 1 Publication1
Mutagenesisi207Y → D in frs-tg221; induces embryonic hypochronic anemia. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352541 – 332Mitoferrin-1Add BLAST332

Proteomic databases

PaxDbiQ287T7.

Expressioni

Tissue specificityi

Highly expressed in hematopoietic organs, Expressed in the intermediate cell mass (ICM), a tissue equivalent to the mammalian extraembryonic yolk-sac blood islands. Colocalizes with gata1.1 Publication

Gene expression databases

BgeeiENSDARG00000073743.
ExpressionAtlasiQ287T7. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090636.

Structurei

3D structure databases

ProteinModelPortaliQ287T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 119Solcar 1Add BLAST89
Repeati129 – 213Solcar 2Add BLAST85
Repeati220 – 314Solcar 3Add BLAST95

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ287T7.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG091G0PU8.
PhylomeDBiQ287T7.
TreeFamiTF314118.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q287T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRTDAVLA SLEMSEPVKN DEDYESLPAH ASLGTHMTAG AVAGILEHTV
60 70 80 90 100
MYPVDSVKTR MQSLQPDPKA QYRSVYGALK RIVRTEGLLR PLRGLNITVL
110 120 130 140 150
GAGPAHALYF ACYERIKRSL SDVIQNGGNS HIANGVAGSV ATVLHDAVMN
160 170 180 190 200
PAEVVKQRMQ MYNSPYRSLY DCVLMVSRKE GLAAFYRSYS TQLTMNIPFQ
210 220 230 240 250
AVHFITYEFM QEHFNPHRQY RPETHIISGA AAGAVSAAVT TPLDVCKTLL
260 270 280 290 300
NTQENVALSS AHVSGHLSGM VNALRTVYRL GGVPAFFKGI QARVIYQMPS
310 320 330
TAIAWSVYEF FKYFLTQHES HVQEVSHKTS PT
Length:332
Mass (Da):36,711
Last modified:April 4, 2006 - v1
Checksum:i227032AD6BCA8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ112224 mRNA. Translation: ABA33608.1.
DQ112225 mRNA. Translation: ABA33609.1.
RefSeqiNP_001035060.1. NM_001039971.1.
UniGeneiDr.116247.

Genome annotation databases

EnsembliENSDART00000099863; ENSDARP00000090636; ENSDARG00000073743.
GeneIDi387000.
KEGGidre:387000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ112224 mRNA. Translation: ABA33608.1.
DQ112225 mRNA. Translation: ABA33609.1.
RefSeqiNP_001035060.1. NM_001039971.1.
UniGeneiDr.116247.

3D structure databases

ProteinModelPortaliQ287T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090636.

Protein family/group databases

TCDBi2.A.29.5.3. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbiQ287T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000099863; ENSDARP00000090636; ENSDARG00000073743.
GeneIDi387000.
KEGGidre:387000.

Organism-specific databases

CTDi51312.
ZFINiZDB-GENE-031118-202. slc25a37.

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ287T7.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG091G0PU8.
PhylomeDBiQ287T7.
TreeFamiTF314118.

Miscellaneous databases

PROiQ287T7.

Gene expression databases

BgeeiENSDARG00000073743.
ExpressionAtlasiQ287T7. differential.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFRN1_DANRE
AccessioniPrimary (citable) accession number: Q287T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.