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Protein

Alpha-fetoprotein

Gene

AFP

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Copper or nickelBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Nickel

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-fetoprotein
Alternative name(s):
Alpha-1-fetoprotein
Alpha-fetoglobulin
Gene namesi
Name:AFP
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 609591Alpha-fetoproteinPRO_0000001099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 114PROSITE-ProRule annotation
Modified residuei111 – 1111PhosphoserineBy similarity
Disulfide bondi113 ↔ 124PROSITE-ProRule annotation
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Modified residuei344 – 3441PhosphoserineBy similarity
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei444 – 4441PhosphoserineBy similarity
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiQ28789.

Expressioni

Tissue specificityi

Plasma. Synthesized by the fetal liver and yolk sac.

Interactioni

Subunit structurei

Dimeric and trimeric forms have been found in addition to the monomeric form.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000027765.

Structurei

3D structure databases

ProteinModelPortaliQ28789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 210192Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 402192Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini403 – 601199Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiQ28789.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 2 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVESIFLI FLLNFTESRT LHRNEYGIAS ILDSYQCTAE INLTDLATIF
60 70 80 90 100
FAQFVQEATY KEVSKMVKDA LTAIEKPTGD EQSAGCLENQ LPAFLEELCR
110 120 130 140 150
EKEILEKYGH SDCCSQSEEG RHNCFLAHKK PTPASIPFFQ VPEPVTSCEA
160 170 180 190 200
YEEDRETFMN KFIYEIARRH PFLYAPTILL WAARYDKIIP SCCKAENAVE
210 220 230 240 250
CFQTKAATVT KELRESSLLN QHACAVMKNF GTRTFQAITV TKLSQKFTKV
260 270 280 290 300
NFTEIQKLVL DVAHVHEHCC RGDVLDCLQD GEKIMSYICS QQDTLSNKIT
310 320 330 340 350
ECCKLTTLER GQCIIHAEND EKPEGLSPNL NRFLGDRDFN QFSSGEKNIF
360 370 380 390 400
LASFVHEYSR RHPQLAVSVI LRVAKGYQEL LEKCFQTENP LECQDKGEEE
410 420 430 440 450
LQKYIQESQA LAKRSCGLFQ KLGEYYLQNA FLVAYTKKAP QLTSSELMAI
460 470 480 490 500
TRKMAATAAT CCQLSEDKLL ACGEGAADII IGHLCIRHET TPVNPGVGQC
510 520 530 540 550
CTSSYANRRP CFSSLVVDET YVPPAFSDDK FIFHKDLCQA QGVALQTMKQ
560 570 580 590 600
EFLINLVKQK PQITEEQLEA VIADFSGLLE KCCQGQEQEV CFAEEGQKLI

SKTRAALGV
Length:609
Mass (Da):68,742
Last modified:November 1, 1996 - v1
Checksum:iC032987CAD0E672B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21916 Genomic DNA. Translation: AAA91641.1.
PIRiJC4258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21916 Genomic DNA. Translation: AAA91641.1.
PIRiJC4258.

3D structure databases

ProteinModelPortaliQ28789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000027765.

Proteomic databases

PaxDbiQ28789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiQ28789.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 2 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFETA_PANTR
AccessioniPrimary (citable) accession number: Q28789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.