HBG1

Functionⁱ

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	64	Iron (heme distal ligand)PROSITE-ProRule annotation		1
Metal bindingⁱ	93	Iron (heme proximal ligand)PROSITE-ProRule annotation		1

GO - Molecular functionⁱ

heme binding Source: InterPro
iron ion binding Source: InterPro
oxygen binding Source: InterPro
oxygen carrier activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Oxygen transport, Transport
Ligand	Heme, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hemoglobin subunit gamma-1 Alternative name(s): Gamma-1-globin Hemoglobin gamma-1 chain Hemoglobin gamma-A chain
Gene namesⁱ	Name:HBG1
Organismⁱ	Pan paniscus (Pygmy chimpanzee) (Bonobo)
Taxonomic identifierⁱ	9597 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000053261	2 – 147	Hemoglobin subunit gamma-1Add BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycineBy similarity	1
Modified residueⁱ	13	PhosphothreonineBy similarity	1
Modified residueⁱ	45	PhosphoserineBy similarity	1
Modified residueⁱ	51	PhosphoserineBy similarity	1
Modified residueⁱ	53	PhosphoserineBy similarity	1
Modified residueⁱ	60	N6-acetyllysineBy similarity	1
Modified residueⁱ	83	N6-acetyllysineBy similarity	1
Modified residueⁱ	94	S-nitrosocysteineBy similarity	1
Modified residueⁱ	140	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PRIDEⁱ	Q28779.

PRIDEⁱ

Q28779.

Expressionⁱ

Tissue specificityⁱ

Red blood cells.

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). The ratio of gamma-G to gamma-A chains in is approximately 2:1 in infant chimpanzee, and 1:2 in the adult.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q28779.
SMRⁱ	Q28779.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENⁱ	HBG009709.

HOVERGENⁱ

HBG009709.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08925. Hb-beta_like. 1 hit.
InterProⁱ	View protein in InterPro IPR000971. Globin. IPR009050. Globin-like_sf. IPR002337. Haemoglobin_b.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00042. Globin. 1 hit.
PRINTSⁱ	PR00814. BETAHAEM.
SUPFAMⁱ	SSF46458. SSF46458. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01033. GLOBIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q28779-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGHFTEEDKA TITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS 
        60         70         80         90        100
SASAIMGNPK VKAHGKKVLT SLGDAIKHLD DLKGTFAQLS ELHCDKLHVD 
       110        120        130        140 
PENFRLLGNV LVTVLAIHFG KEFTPEVQAS WQKMVTAVAS ALSSRYH

Length:147

Mass (Da):16,168

Last modified:January 23, 2007 - v3

Checksum:ⁱ8FCDDD1527AC6DDE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93716 Unassigned DNA. Translation: AAA72113.1.
PIRⁱ	I37002.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q28779	H2R5L8	Pan troglodytes (Chimpanzee)	147	UniRef100_Q28779	Cluster: Hemoglobin subunit gamma-1	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q28779	P69892 P62742 P61921 D9YZU9 A0A0P5WXU3 A0A2J8P6N7 Q9UJ01 UPI00001F9BB0 Q9UNL6 P62741 +21	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Daphnia magna Pan paniscus (Pygmy chimpanzee) (Bonobo) Pongo pygmaeus (Bornean orangutan) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Papio anubis (Olive baboon)	147	UniRef90_P69892	Cluster: Hemoglobin subunit gamma-2	32

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q28779	P69892 P62742 P61921 D9YZU9 A0A0P5WXU3 A0A2J8P6N7 Q9UJ01 UPI00001F9BB0 Q9UNL6 E7CYP2 +772	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Daphnia magna Pan paniscus (Pygmy chimpanzee) (Bonobo) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pongo pygmaeus (Bornean orangutan) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) And more	147	UniRef50_P69892	Cluster: Hemoglobin subunit gamma-2	783

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93716 Unassigned DNA. Translation: AAA72113.1.
PIRⁱ	I37002.

3D structure databases

ProteinModelPortalⁱ	Q28779.
SMRⁱ	Q28779.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q28779.

PRIDEⁱ

Q28779.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG009709.

HOVERGENⁱ

HBG009709.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08925. Hb-beta_like. 1 hit.
InterProⁱ	View protein in InterPro IPR000971. Globin. IPR009050. Globin-like_sf. IPR002337. Haemoglobin_b.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00042. Globin. 1 hit.
PRINTSⁱ	PR00814. BETAHAEM.
SUPFAMⁱ	SSF46458. SSF46458. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01033. GLOBIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HBG1_PANPA
Accessionⁱ	Q28779Primary (citable) accession number: Q28779
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 22, 2017
	This is version 78 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB - Q28779 (HBG1_PANPA)

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Hemoglobin subunit gamma-1

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Functionⁱ

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Cytosol

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

Expressionⁱ

Tissue specificityⁱ

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q28779 (HBG1_PANPA)

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Hemoglobin subunit gamma-1

HBG1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ