UniProtKB - Q28779 (HBG1_PANPA)
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Protein
Hemoglobin subunit gamma-1
Gene
HBG1
Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Functioni
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Iron (heme distal ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 93 | Iron (heme proximal ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit gamma-1Alternative name(s): Gamma-1-globin Hemoglobin gamma-1 chain Hemoglobin gamma-A chain |
Gene namesi | Name:HBG1 |
Organismi | Pan paniscus (Pygmy chimpanzee) (Bonobo) |
Taxonomic identifieri | 9597 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000053261 | 2 – 147 | Hemoglobin subunit gamma-1Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineBy similarity | 1 | |
Modified residuei | 13 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 45 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Modified residuei | 53 | PhosphoserineBy similarity | 1 | |
Modified residuei | 60 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 83 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 94 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 140 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylationProteomic databases
PRIDEi | Q28779. |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). The ratio of gamma-G to gamma-A chains in is approximately 2:1 in infant chimpanzee, and 1:2 in the adult.
Structurei
3D structure databases
ProteinModelPortali | Q28779. |
SMRi | Q28779. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
HOVERGENi | HBG009709. |
Family and domain databases
CDDi | cd08925. Hb-beta_like. 1 hit. |
InterProi | View protein in InterPro IPR000971. Globin. IPR009050. Globin-like_sf. IPR002337. Haemoglobin_b. |
Pfami | View protein in Pfam PF00042. Globin. 1 hit. |
PRINTSi | PR00814. BETAHAEM. |
SUPFAMi | SSF46458. SSF46458. 1 hit. |
PROSITEi | View protein in PROSITE PS01033. GLOBIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q28779-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHFTEEDKA TITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS
60 70 80 90 100
SASAIMGNPK VKAHGKKVLT SLGDAIKHLD DLKGTFAQLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVTVLAIHFG KEFTPEVQAS WQKMVTAVAS ALSSRYH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93716 Unassigned DNA. Translation: AAA72113.1. |
PIRi | I37002. |
Similar proteinsi
Entry informationi
Entry namei | HBG1_PANPA | |
Accessioni | Q28779Primary (citable) accession number: Q28779 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | November 22, 2017 | |
This is version 78 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |