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Q28773 (KLK1_PAPHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein-1

EC=3.4.21.35
Alternative name(s):
Kidney/pancreas/salivary gland kallikrein
Tissue kallikrein
Gene names
Name:KLK1
OrganismPapio hamadryas (Hamadryas baboon)
Taxonomic identifier9557 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Zymogen
Gene Ontology (GO)
   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 246Activation peptide Probable
PRO_0000027927
Chain25 – 258234Kallikrein-1
PRO_0000027928

Regions

Domain25 – 255231Peptidase S1

Sites

Active site621Charge relay system By similarity
Active site1171Charge relay system By similarity
Active site2101Charge relay system By similarity

Amino acid modifications

Glycosylation901O-linked (GalNAc...) By similarity
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1011O-linked (GalNAc...) By similarity
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1631O-linked (GalNAc...) By similarity
Disulfide bond31 ↔ 170 By similarity
Disulfide bond47 ↔ 63 By similarity
Disulfide bond149 ↔ 216 By similarity
Disulfide bond181 ↔ 195 By similarity
Disulfide bond206 ↔ 231 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28773 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8254BFEBC84F36E4

FASTA25828,339
        10         20         30         40         50         60 
MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI LVHPQWVLTA 

        70         80         90        100        110        120 
AHCIGDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPCFNM SLLKNHTRQA DEDYSHDLML 

       130        140        150        160        170        180 
LRLTQPAEIT DAVQVVELPT QEPEVGSTCL ASGWGSIEPE NFSYPDDLQC VDLKILPNDK 

       190        200        210        220        230        240 
CAKAHTQKVT EFMLCAGHLE GGKDTCVGDS GGPLTCDGVL QGVTSWGYIP CGSPNKPAVF 

       250 
VRVLSYVKWI EDTIAENS 

« Hide

References

[1]"Characterization of the baboon glandular kallikrein locus."
Perelygina L.M., Kammerer C.M., Henkel R.D.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43121 mRNA. Translation: AAA73523.1.

3D structure databases

ProteinModelPortalQ28773.
SMRQ28773. Positions 25-258.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG013304.

Enzyme and pathway databases

BRENDA3.4.21.35. 4522.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKLK1_PAPHA
AccessionPrimary (citable) accession number: Q28773
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries