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Q28773

- KLK1_PAPHA

UniProt

Q28773 - KLK1_PAPHA

Protein

Kallikrein-1

Gene

KLK1

Organism
Papio hamadryas (Hamadryas baboon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Charge relay systemBy similarity
    Active sitei117 – 1171Charge relay systemBy similarity
    Active sitei210 – 2101Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.35. 4522.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-1 (EC:3.4.21.35)
    Alternative name(s):
    Kidney/pancreas/salivary gland kallikrein
    Tissue kallikrein
    Gene namesi
    Name:KLK1
    OrganismiPapio hamadryas (Hamadryas baboon)
    Taxonomic identifieri9557 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000027927
    Chaini25 – 258234Kallikrein-1PRO_0000027928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 170PROSITE-ProRule annotation
    Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
    Glycosylationi90 – 901O-linked (GalNAc...)By similarity
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011O-linked (GalNAc...)By similarity
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 216PROSITE-ProRule annotation
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631O-linked (GalNAc...)By similarity
    Disulfide bondi181 ↔ 195PROSITE-ProRule annotation
    Disulfide bondi206 ↔ 231PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliQ28773.
    SMRiQ28773. Positions 25-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 255231Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28773-1 [UniParc]FASTAAdd to Basket

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    MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI    50
    LVHPQWVLTA AHCIGDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPCFNM 100
    SLLKNHTRQA DEDYSHDLML LRLTQPAEIT DAVQVVELPT QEPEVGSTCL 150
    ASGWGSIEPE NFSYPDDLQC VDLKILPNDK CAKAHTQKVT EFMLCAGHLE 200
    GGKDTCVGDS GGPLTCDGVL QGVTSWGYIP CGSPNKPAVF VRVLSYVKWI 250
    EDTIAENS 258
    Length:258
    Mass (Da):28,339
    Last modified:November 1, 1996 - v1
    Checksum:i8254BFEBC84F36E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43121 mRNA. Translation: AAA73523.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43121 mRNA. Translation: AAA73523.1 .

    3D structure databases

    ProteinModelPortali Q28773.
    SMRi Q28773. Positions 25-258.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013304.

    Enzyme and pathway databases

    BRENDAi 3.4.21.35. 4522.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the baboon glandular kallikrein locus."
      Perelygina L.M., Kammerer C.M., Henkel R.D.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiKLK1_PAPHA
    AccessioniPrimary (citable) accession number: Q28773
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3