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Q28773

- KLK1_PAPHA

UniProt

Q28773 - KLK1_PAPHA

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Protein
Kallikrein-1
Gene
KLK1
Organism
Papio hamadryas (Hamadryas baboon)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay system By similarity
Active sitei117 – 1171Charge relay system By similarity
Active sitei210 – 2101Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35. 4522.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-1 (EC:3.4.21.35)
Alternative name(s):
Kidney/pancreas/salivary gland kallikrein
Tissue kallikrein
Gene namesi
Name:KLK1
OrganismiPapio hamadryas (Hamadryas baboon)
Taxonomic identifieri9557 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Propeptidei19 – 246Activation peptide Inferred
PRO_0000027927
Chaini25 – 258234Kallikrein-1
PRO_0000027928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 170 By similarity
Disulfide bondi47 ↔ 63 By similarity
Glycosylationi90 – 901O-linked (GalNAc...) By similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011O-linked (GalNAc...) By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 216 By similarity
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631O-linked (GalNAc...) By similarity
Disulfide bondi181 ↔ 195 By similarity
Disulfide bondi206 ↔ 231 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ28773.
SMRiQ28773. Positions 25-258.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 255231Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28773-1 [UniParc]FASTAAdd to Basket

« Hide

MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI    50
LVHPQWVLTA AHCIGDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPCFNM 100
SLLKNHTRQA DEDYSHDLML LRLTQPAEIT DAVQVVELPT QEPEVGSTCL 150
ASGWGSIEPE NFSYPDDLQC VDLKILPNDK CAKAHTQKVT EFMLCAGHLE 200
GGKDTCVGDS GGPLTCDGVL QGVTSWGYIP CGSPNKPAVF VRVLSYVKWI 250
EDTIAENS 258
Length:258
Mass (Da):28,339
Last modified:November 1, 1996 - v1
Checksum:i8254BFEBC84F36E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43121 mRNA. Translation: AAA73523.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43121 mRNA. Translation: AAA73523.1 .

3D structure databases

ProteinModelPortali Q28773.
SMRi Q28773. Positions 25-258.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Enzyme and pathway databases

BRENDAi 3.4.21.35. 4522.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the baboon glandular kallikrein locus."
    Perelygina L.M., Kammerer C.M., Henkel R.D.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiKLK1_PAPHA
AccessioniPrimary (citable) accession number: Q28773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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