Q28748 (A4_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amyloid beta A4 protein

Alternative name(s):
ABPP
Short name=APP
Alzheimer disease amyloid A4 protein homolog

Cleaved into the following 6 chains:

1. Soluble APP-beta
   Short name=S-APP-beta
2. CTF-alpha
3. Beta-amyloid protein 42
   Alternative name(s):
   Beta-APP42
4. Beta-amyloid protein 40
   Alternative name(s):
   Beta-APP40
5. Gamma-secretase C-terminal fragment 59
   Alternative name(s):
   Gamma-CTF(59)
6. Gamma-secretase C-terminal fragment 57
   Alternative name(s):
   Gamma-CTF(57)

Gene names

Name:

APP

Organism

Oryctolagus cuniculus (Rabbit) [Complete proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	58 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O) By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the APP family.

Ontologies

Keywords
Cellular component	Amyloid Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›58	›58	Amyloid beta A4 protein		PRO_0000226242
	Chain	‹1 – 5	›5	Soluble APP-beta By similarity		PRO_0000000153
	Chain	6 – ›58	›53	CTF-alpha By similarity		PRO_0000000154
	Chain	6 – 47	42	Beta-amyloid protein 42 By similarity		PRO_0000000155
	Chain	6 – 45	40	Beta-amyloid protein 40 By similarity		PRO_0000000156
	Chain	46 – ›58	›13	Gamma-secretase C-terminal fragment 59 By similarity		PRO_0000000157
	Chain	48 – ›58	›11	Gamma-secretase C-terminal fragment 57 By similarity		PRO_0000000158
Regions
	Topological domain	‹1 – 33	›33	Extracellular Potential
	Transmembrane	34 – 57	24	Helical; Potential
	Topological domain	58	›1	Cytoplasmic Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	58	1

Sequences

	Sequence		Length	Mass (Da)
	Q28748 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: F434209D88EBA82D	FASTA	58	6,300
	10 20 30 40 50 SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM VGGVVIATVI VITLVMLK

References

[1]	"Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis." Johnstone E.M., Chaney M.O., Norris F.H., Pascual R., Little S.P. Brain Res. Mol. Brain Res. 10:299-305(1991) [PubMed: 1656157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56129 mRNA. Translation: CAA39594.1.
UniGene	Ocu.3284.
3D structure databases
ProteinModelPortal	Q28748.
SMR	Q28748. Positions 6-47.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28748.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063252.
OrthoDB	EOG45B1F4.
Family and domain databases
InterPro	IPR013803. Amyloid_glyco_Abeta. [Graphical view]
Gene3D	G3DSA:4.10.230.10. Amyloid_glyco_Abeta. 1 hit.
Pfam	PF03494. Beta-APP. 1 hit. [Graphical view]
PRINTS	PR00204. BETAAMYLOID.
PROSITE	PS00319. A4_EXTRA. Partial match. PS00320. A4_INTRA. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4_RABIT

Accession

Primary (citable) accession number: Q28748

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program